Last reviewed 2026-04-22 · How we verify

Desogestrel luteal phase

Desogestrel is a progestin that prevents pregnancy by suppressing ovulation and altering cervical mucus and endometrial conditions.

Desogestrel is a progestin that prevents pregnancy by suppressing ovulation and altering cervical mucus and endometrial conditions. Used for Contraception (pregnancy prevention).

At a glance

Mechanism of action

Desogestrel is a third-generation synthetic progestin used in hormonal contraception. It works primarily by inhibiting the luteinizing hormone (LH) surge necessary for ovulation, while also increasing cervical mucus viscosity to impede sperm penetration and thinning the endometrium to prevent implantation. The luteal phase formulation delivers the progestin during the latter part of the menstrual cycle.

Approved indications

• Contraception (pregnancy prevention)

Common side effects

• Headache
• Nausea
• Breast tenderness
• Irregular bleeding
• Mood changes

Key clinical trials

• New Ovarian Stimulation With Random Start, Use of Progestin Protocol for Oocyte Donors (PHASE3)
• Antral Follicle Priming Prior to ICSI (Intracytoplasmic Sperm Injection) in Previously Diagnosed Low Responders (PHASE2)
• Mid-luteal Phase Synchronization of Ovarian Folliculogenesis in Women (NA)

Primary sources

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Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

• Desogestrel luteal phase CI brief — competitive landscape report
• Desogestrel luteal phase updates RSS · CI watch RSS
• Centre Hospitalier Intercommunal Creteil portfolio CI