{"id":"desogestrel-luteal-phase","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Breast tenderness"},{"rate":null,"effect":"Irregular bleeding"},{"rate":null,"effect":"Mood changes"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Desogestrel is a third-generation synthetic progestin used in hormonal contraception. It works primarily by inhibiting the luteinizing hormone (LH) surge necessary for ovulation, while also increasing cervical mucus viscosity to impede sperm penetration and thinning the endometrium to prevent implantation. The luteal phase formulation delivers the progestin during the latter part of the menstrual cycle.","oneSentence":"Desogestrel is a progestin that prevents pregnancy by suppressing ovulation and altering cervical mucus and endometrial conditions.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:09:08.098Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Contraception (pregnancy prevention)"}]},"trialDetails":[{"nctId":"NCT03895099","phase":"PHASE3","title":"New Ovarian Stimulation With Random Start, Use of Progestin Protocol for Oocyte Donors","status":"COMPLETED","sponsor":"Centre Hospitalier Intercommunal Creteil","startDate":"2020-09-04","conditions":"Infertility","enrollment":110},{"nctId":"NCT01310647","phase":"PHASE2","title":"Antral Follicle Priming Prior to ICSI (Intracytoplasmic Sperm Injection) in Previously Diagnosed Low Responders","status":"COMPLETED","sponsor":"Instituto de Investigacion Sanitaria La Fe","startDate":"2011-06","conditions":"Ovarian Diseases","enrollment":66},{"nctId":"NCT00565240","phase":"NA","title":"Mid-luteal Phase Synchronization of Ovarian Folliculogenesis in Women","status":"COMPLETED","sponsor":"University of Saskatchewan","startDate":"2007-11","conditions":"Ovarian Follicle","enrollment":41}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":25,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Desogestrel luteal phase","genericName":"Desogestrel luteal phase","companyName":"Centre Hospitalier Intercommunal Creteil","companyId":"centre-hospitalier-intercommunal-creteil","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Desogestrel is a progestin that prevents pregnancy by suppressing ovulation and altering cervical mucus and endometrial conditions. Used for Contraception (pregnancy prevention).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}