Last reviewed · How we verify
Mid-luteal Phase Synchronization of Ovarian Folliculogenesis in Women Protocol: WHIRL-07-2971
We hypothesize that administration of an aromatase inhibitor (AI) and hormonal contraceptives (HC) in the mid-luteal phase of the menstrual cycle will result in atresia of the follicles in the extant wave and cause synchronous re-emergence of a new follicular wave. We anticipate that this will provide us with information to facilitate the development of a new method for ovarian synchronization; a safer, more effective ovulation induction therapy; a new method for emergency contraception; and a greater understanding of human folliculogenesis.
Details
| Lead sponsor | University of Saskatchewan |
|---|---|
| Phase | NA |
| Status | COMPLETED |
| Enrolment | 41 |
| Start date | 2007-11 |
| Completion | 2009-09 |
Conditions
- Ovarian Follicle
Interventions
- Marvelon
- Nuvaring
- Letrozole
Primary outcomes
- To evaluate differences in the mechanisms of atresia, initiation of a new synchronous follicular wave, interval to follicle wave emergence, interval to emergence of dominant follicle, interval to menstruation, and endometrial thickness/pattern. — 24-28 days
Countries
Canada