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Additional vaginal progesterone
Progesterone acts on the progesterone receptor.
Progesterone acts on the progesterone receptor. Used for Prevention of preterm birth.
At a glance
| Generic name | Additional vaginal progesterone |
|---|---|
| Sponsor | Hillel Yaffe Medical Center |
| Drug class | Progestin |
| Target | Progesterone receptor |
| Modality | Small molecule |
| Therapeutic area | Gynecology |
| Phase | Phase 1 |
Mechanism of action
Progesterone binds to the progesterone receptor, which is a nuclear receptor that regulates gene expression involved in the development and maintenance of the female reproductive system.
Approved indications
- Prevention of preterm birth
Common side effects
- Vaginal discharge
- Vaginal bleeding
- Headache
Key clinical trials
- Hormone Replacement Therapy in Adolescents With Premature Ovarian Insufficiency (PHASE3)
- The Combined Effect of Magnesium, Palmitoylethanolamide, High-Molecular-weight Hyaluronic Acid, Vitamin B6, and Vitamin D in Preventing Preterm Birth: (NA)
- Is There a Need for Luteal Support in Modified Natural Cycle Frozen Embryo Transfer Cycles (PHASE4)
- Impact of IVF Hormonal Therapy on Endometrial Receptivity and Endometrial Senescent Cell Pathological Accumulation
- Addition of Gonadotropin Releasing Hormone Agonist to Luteal Phase Support (PHASE4)
- MIcronized PROgesterone in Frozen Embryo Transfer Cycles (PHASE3)
- Impact of Corpus Luteum Presence or Absence in the Incidence of Preeclampsia After Frozen Embryo Transfer (NA)
- Hormonal Monitoring and Progesterone Adjustment in Frozen Embryo Transfer Cycles (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Additional vaginal progesterone CI brief — competitive landscape report
- Additional vaginal progesterone updates RSS · CI watch RSS
- Hillel Yaffe Medical Center portfolio CI