{"id":"additional-vaginal-progesterone","safety":{"commonSideEffects":[{"rate":"10%","effect":"Vaginal discharge"},{"rate":"5%","effect":"Vaginal bleeding"},{"rate":"5%","effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Progesterone binds to the progesterone receptor, which is a nuclear receptor that regulates gene expression involved in the development and maintenance of the female reproductive system.","oneSentence":"Progesterone acts on the progesterone receptor.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T05:49:42.589Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of preterm birth"}]},"trialDetails":[{"nctId":"NCT06851754","phase":"PHASE3","title":"Hormone Replacement Therapy in Adolescents With Premature Ovarian Insufficiency","status":"RECRUITING","sponsor":"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","startDate":"2025-07-17","conditions":"Premature Ovarian Insufficiency","enrollment":185},{"nctId":"NCT07305519","phase":"NA","title":"The Combined Effect of Magnesium, Palmitoylethanolamide, High-Molecular-weight Hyaluronic Acid, Vitamin B6, and Vitamin D in Preventing Preterm Birth:","status":"NOT_YET_RECRUITING","sponsor":"University of Roma La Sapienza","startDate":"2026-01-01","conditions":"Preterm Labor","enrollment":150},{"nctId":"NCT06875752","phase":"PHASE4","title":"Is There a Need for Luteal Support in Modified Natural Cycle Frozen Embryo Transfer Cycles","status":"RECRUITING","sponsor":"Dunamenti REK Istenhegyi IVF Center","startDate":"2025-04-12","conditions":"Luteal Support, Frozen Embryo Transfer (FET)","enrollment":180},{"nctId":"NCT06280560","phase":"","title":"Impact of IVF Hormonal Therapy on Endometrial Receptivity and Endometrial Senescent Cell Pathological Accumulation","status":"RECRUITING","sponsor":"Fundación IVI","startDate":"2024-02-01","conditions":"Endometrial Receptivity","enrollment":60},{"nctId":"NCT05286554","phase":"PHASE4","title":"Addition of Gonadotropin Releasing Hormone Agonist to Luteal Phase Support","status":"COMPLETED","sponsor":"Alexandria University","startDate":"2022-03-17","conditions":"Female Infertility","enrollment":75},{"nctId":"NCT05899010","phase":"PHASE3","title":"MIcronized PROgesterone in Frozen Embryo Transfer Cycles","status":"RECRUITING","sponsor":"Fundación Santiago Dexeus Font","startDate":"2023-07-05","conditions":"Infertility","enrollment":1020},{"nctId":"NCT04092829","phase":"NA","title":"Impact of Corpus Luteum Presence or Absence in the Incidence of Preeclampsia After Frozen Embryo Transfer","status":"TERMINATED","sponsor":"Instituto Valenciano de Infertilidad, IVI VALENCIA","startDate":"2019-09-16","conditions":"Pre-Eclampsia, Frozen Embryo Transfer","enrollment":591},{"nctId":"NCT05189145","phase":"NA","title":"Hormonal Monitoring and Progesterone Adjustment in Frozen Embryo Transfer Cycles","status":"COMPLETED","sponsor":"Alexandria University","startDate":"2019-10-01","conditions":"Female Infertility","enrollment":600},{"nctId":"NCT06006091","phase":"NA","title":"The Effectiveness of the Letrozole-induced Endometrial Preparation Protocol in Frozen-thawed Embryo Transfer (FET)","status":"RECRUITING","sponsor":"International Peace Maternity and Child Health Hospital","startDate":"2023-08-01","conditions":"Letrozole, Infertility, Female","enrollment":858},{"nctId":"NCT06005207","phase":"NA","title":"Vaginal Progesterone Improves Clinical Outcomes of RIF Patients","status":"UNKNOWN","sponsor":"Nanjing University","startDate":"2023-08-01","conditions":"Infertility, Female","enrollment":152},{"nctId":"NCT05576740","phase":"","title":"Influence of Menstrual Cycle Stages on Female Athletes","status":"COMPLETED","sponsor":"Universitat Jaume I","startDate":"2022-03-16","conditions":"Menstrual Cycle, Sports","enrollment":41},{"nctId":"NCT04330066","phase":"","title":"Impact of Endometrial Compaction in Euploid Frozen Embryo Transfers","status":"UNKNOWN","sponsor":"Boston IVF","startDate":"2020-09-01","conditions":"Infertility, Female","enrollment":187},{"nctId":"NCT03740568","phase":"NA","title":"Effect of Intervention on Progesterone Levels Before Euploid Embryo Transfer in Pregnancy Outcomes.","status":"COMPLETED","sponsor":"Fundacion Dexeus","startDate":"2018-11-15","conditions":"Infertility, Progesterone, Frozen Embryo Transfer","enrollment":598},{"nctId":"NCT02736032","phase":"PHASE3","title":"Cryopreserved-thawed Embryo Transfer With or Without Gonadotropin Releasing Hormone Agonist","status":"COMPLETED","sponsor":"Cairo University","startDate":"2016-03","conditions":"Infertility","enrollment":310},{"nctId":"NCT01888744","phase":"PHASE4","title":"Preimplantation Genetic Diagnosis (PGD) With Gonadotropin-releasing Hormone (GnRH) Agonist Versus Antagonist","status":"COMPLETED","sponsor":"Universitair Ziekenhuis Brussel","startDate":"2010-09","conditions":"Reproductive Endocrinology, Fertility, Optimal Stimulation Protocol","enrollment":120},{"nctId":"NCT01760278","phase":"PHASE4","title":"Assessment of Implantation Potential of Embryos by Time-lapse Technology","status":"UNKNOWN","sponsor":"Bloom IVF and Fertility Centre","startDate":"2012-12","conditions":"Embryo/Fetus Death, Blastocyst Disintegration, Aneuploidy","enrollment":200},{"nctId":"NCT01367912","phase":"NA","title":"Timing of Estrogen Support During the Luteal Phase of in Vitro Fertilization (IVF)/Intracytoplasmic Sperm Injection (ICSI) Cycle","status":"COMPLETED","sponsor":"Zekai Tahir Burak Women's Health Research and Education Hospital","startDate":"2008-02","conditions":"Infertility","enrollment":301},{"nctId":"NCT01356524","phase":"NA","title":"Relationship Between Mid-luteal Serum Progesterone Levels to Pregnancy Rates in Assisted Reproductive Techniques (ART)","status":"UNKNOWN","sponsor":"Hillel Yaffe Medical Center","startDate":"2011-07","conditions":"Infertility","enrollment":160}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":135,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_1","status":"active","brandName":"Additional vaginal progesterone","genericName":"Additional vaginal progesterone","companyName":"Hillel Yaffe Medical Center","companyId":"hillel-yaffe-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Progesterone acts on the progesterone receptor. Used for Prevention of preterm birth.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}