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Desogestrel ovulatory phase

Centre Hospitalier Intercommunal Creteil · Phase 3 active Small molecule

Desogestrel is a progestin that prevents ovulation by suppressing the luteinizing hormone surge and thickening cervical mucus to inhibit sperm penetration.

Desogestrel is a progestin that prevents ovulation by suppressing the luteinizing hormone surge and thickening cervical mucus to inhibit sperm penetration. Used for Ovulation prevention for contraception.

At a glance

Generic nameDesogestrel ovulatory phase
SponsorCentre Hospitalier Intercommunal Creteil
Drug classProgestin (hormonal contraceptive)
TargetProgesterone receptor
ModalitySmall molecule
Therapeutic areaContraception / Reproductive Health
PhasePhase 3

Mechanism of action

Desogestrel is a third-generation synthetic progestin used in hormonal contraceptives. It acts primarily by inhibiting the gonadotropin-releasing hormone (GnRH)-driven surge of luteinizing hormone (LH) that triggers ovulation. Additionally, it increases cervical mucus viscosity, creating a barrier to sperm transport, and alters the endometrium to reduce implantation likelihood.

Approved indications

Common side effects

Key clinical trials

Primary sources

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SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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