{"id":"desogestrel-ovulatory-phase","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Breast tenderness"},{"rate":null,"effect":"Irregular bleeding"},{"rate":null,"effect":"Mood changes"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Desogestrel is a third-generation synthetic progestin used in hormonal contraceptives. It acts primarily by inhibiting the gonadotropin-releasing hormone (GnRH)-driven surge of luteinizing hormone (LH) that triggers ovulation. Additionally, it increases cervical mucus viscosity, creating a barrier to sperm transport, and alters the endometrium to reduce implantation likelihood.","oneSentence":"Desogestrel is a progestin that prevents ovulation by suppressing the luteinizing hormone surge and thickening cervical mucus to inhibit sperm penetration.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:09:08.122Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Ovulation prevention for contraception"}]},"trialDetails":[{"nctId":"NCT03895099","phase":"PHASE3","title":"New Ovarian Stimulation With Random Start, Use of Progestin Protocol for Oocyte Donors","status":"COMPLETED","sponsor":"Centre Hospitalier Intercommunal Creteil","startDate":"2020-09-04","conditions":"Infertility","enrollment":110}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Desogestrel ovulatory phase","genericName":"Desogestrel ovulatory phase","companyName":"Centre Hospitalier Intercommunal Creteil","companyId":"centre-hospitalier-intercommunal-creteil","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Desogestrel is a progestin that prevents ovulation by suppressing the luteinizing hormone surge and thickening cervical mucus to inhibit sperm penetration. Used for Ovulation prevention for contraception.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}