Nicotinic acetylcholine receptors — Drug Target

All drugs that target Nicotinic acetylcholine receptors — marketed and clinical-stage. Includes 11 drug classes acting on this target.

Drug classes

Nicotine replacement therapy · Nicotine replacement therapy (NRT) · Nicotinic acetylcholine receptor agonist · Nicotinic receptor agonist · Nicotine replacement therapy combination · Nicotinic acetylcholine receptor agonist; Nicotine replacement therapy (NRT) · Nicotine replacement therapy (combination) · PET imaging agent / radiotracer · Nicotinic acetylcholine receptor partial agonist · Nicotine replacement therapy (NRT) combination · Nicotine replacement therapy agent

Marketed (44)

• Transdermal Nicoderm patch · Ottawa Heart Institute Research Corporation · Nicotine replacement therapy · Smoking Cessation / Addiction Medicine
  Nicotine delivered transdermally binds to nicotinic acetylcholine receptors in the brain, providing nicotine replacement to reduce cravings and withdrawal symptoms during smoking cessation.
• nicotine patch, labeled use · University of Vermont · Nicotine replacement therapy · Gastroenterology
• Cessation Phase Nicotine Patch + Nicotine Mini-Lozenge · University of Wisconsin, Madison · Nicotine replacement therapy (NRT) · Hematology
• Usual brand cigar · Ohio State University Comprehensive Cancer Center
  Usual brand cigar is a tobacco product that contains nicotine, which acts on nicotinic acetylcholine receptors in the brain.
• Pre-Quit Nicotine Gum · University of Wisconsin, Madison · Nicotine replacement therapy · Smoking Cessation / Addiction Medicine
  Pre-Quit Nicotine Gum delivers nicotine orally to reduce withdrawal symptoms and cravings during smoking cessation.
• Nicotine polacrilex lozenge · University of Maryland, Baltimore · Nicotine replacement therapy (NRT) · Addiction Medicine / Smoking Cessation
  Nicotine polacrilex lozenge delivers nicotine through the oral mucosa by binding to nicotinic acetylcholine receptors, providing nicotine replacement to reduce withdrawal symptoms and cravings during smoking cessation.
• Mailed nicotine replacement therapy · Massachusetts General Hospital · Nicotine replacement therapy · Smoking Cessation / Addiction Medicine
  Nicotine replacement therapy delivered by mail provides nicotine to reduce withdrawal symptoms and cravings during smoking cessation.
• Transdermal nicotine patch · University of Pennsylvania · Nicotinic acetylcholine receptor agonist · Psychiatry / Addiction Medicine
  Nicotine binds to nicotinic acetylcholine receptors in the central and peripheral nervous system, providing nicotine replacement to reduce withdrawal symptoms and cravings in tobacco dependence.
• Nicoderm patch first, then Aveva patch · University of Maryland, Baltimore · Nicotine replacement therapy · Addiction Medicine / Smoking Cessation
  A sequential nicotine replacement therapy regimen using transdermal patches to deliver nicotine and support smoking cessation.
• Nicotine gum (C) · 22nd Century Group, Inc. · Nicotinic acetylcholine receptor agonist · Addiction Medicine / Smoking Cessation
  Nicotine gum delivers nicotine through the oral mucosa to bind nicotinic acetylcholine receptors in the brain, reducing cravings and withdrawal symptoms during smoking cessation.
• nicotine nasal spray · Heinrich-Heine University, Duesseldorf · Nicotinic receptor agonist · Smoking Cessation / Addiction Medicine
  Nicotine nasal spray delivers nicotine directly to nasal mucosa for rapid systemic absorption to relieve nicotine withdrawal symptoms and support smoking cessation.
• Nicoderm C-Q Transdermal Product · University of Miami · Nicotine replacement therapy (NRT) · Addiction Medicine / Smoking Cessation
  Nicoderm CQ delivers nicotine transdermally to replace nicotine from cigarettes and reduce withdrawal symptoms during smoking cessation.
• Nicoderm Transdermal Patch · University of Pennsylvania · Nicotinic receptor agonist · Addiction Medicine / Smoking Cessation
  Nicotine binds to nicotinic acetylcholine receptors in the central nervous system to reduce cravings and withdrawal symptoms during smoking cessation.
• Nicoderm Patch · US Department of Veterans Affairs · Nicotine replacement therapy (NRT) · Addiction Medicine / Smoking Cessation
  Nicotine binds to nicotinic acetylcholine receptors in the brain, providing nicotine replacement to reduce cravings and withdrawal symptoms during smoking cessation.
• Pre-Quit Nicotine Patch · University of Wisconsin, Madison · Nicotine replacement therapy (NRT) · Smoking Cessation / Addiction Medicine
  Delivers nicotine transdermally to reduce withdrawal symptoms and cravings during smoking cessation.
• nicotine patch + nicotine lozenge · University of Wisconsin, Madison · Nicotinic acetylcholine receptor agonist · Addiction Medicine / Smoking Cessation
  Nicotine binds to nicotinic acetylcholine receptors in the brain to reduce cravings and withdrawal symptoms during smoking cessation.
• patch + lozenge · University of Wisconsin, Madison · Nicotine replacement therapy (NRT) · Smoking Cessation / Addiction Medicine
  A nicotine replacement therapy combining transdermal patch and oral lozenge delivery to reduce cigarette cravings and withdrawal symptoms during smoking cessation.
• Nicotine (4 mg) · GlaxoSmithKline · Nicotinic acetylcholine receptor agonist · Smoking Cessation / Addiction Medicine
  Nicotine binds to nicotinic acetylcholine receptors in the brain and peripheral nervous system, providing nicotine replacement to reduce cravings and withdrawal symptoms during smoking cessation.
• Placebo Tablet and Nicotine Patch · The Scripps Research Institute · Nicotine replacement therapy (NRT) · Addiction Medicine / Smoking Cessation
  Nicotine from the patch binds to nicotinic acetylcholine receptors in the brain to reduce cravings and withdrawal symptoms during smoking cessation, while the placebo tablet serves as a control comparator.
• NRT (NicoDerm CQ) · University of California, San Francisco · Nicotine replacement therapy (NRT) · Smoking Cessation / Addiction Medicine
  NicoDerm CQ delivers nicotine transdermally to replace nicotine from cigarettes and reduce withdrawal symptoms during smoking cessation.
• Nicotine replacement · Instituto Fernandes Figueira · Nicotinic acetylcholine receptor agonist · Smoking Cessation / Addiction Medicine
  Nicotine binds to nicotinic acetylcholine receptors in the central and peripheral nervous system to reduce cravings and withdrawal symptoms during smoking cessation.
• Standard Duration Combination NRT · University of Wisconsin, Madison · Nicotine replacement therapy combination · Smoking Cessation / Addiction Medicine
  Standard Duration Combination NRT delivers multiple forms of nicotine replacement therapy simultaneously to reduce withdrawal symptoms and support smoking cessation.
• Patch, Nicotine · Assistance Publique - Hôpitaux de Paris · Nicotinic acetylcholine receptor agonist · Addiction Medicine / Smoking Cessation
  Nicotine binds to nicotinic acetylcholine receptors in the central and peripheral nervous system to reduce cravings and withdrawal symptoms during smoking cessation.
• Nicotine Mini-Lozenge for 11 Months · University of Wisconsin, Madison · Nicotinic acetylcholine receptor agonist; Nicotine replacement therapy (NRT) · Smoking Cessation / Addiction Medicine
  Nicotine binds to nicotinic acetylcholine receptors in the brain to reduce cravings and withdrawal symptoms during smoking cessation.
• Extended Duration Combination NRT · University of Wisconsin, Madison · Nicotine replacement therapy (combination) · Smoking Cessation / Addiction Medicine
  Extended Duration Combination NRT delivers multiple forms of nicotine replacement therapy over a prolonged period to reduce withdrawal symptoms and support smoking cessation.
• C-11 labeled nicotine · University of Cincinnati · PET imaging agent / radiotracer · Neurology / Psychiatry (research/diagnostic)
  C-11 labeled nicotine is a radiotracer that binds to nicotinic acetylcholine receptors and allows visualization of receptor distribution and density in the brain using positron emission tomography (PET) imaging.
• Nicorette Gum · University of Miami · Nicotinic acetylcholine receptor agonist · Smoking Cessation / Addiction Medicine
  Nicotine binds to nicotinic acetylcholine receptors in the brain, providing nicotine replacement to reduce cravings and withdrawal symptoms during smoking cessation.
• Nicorette Inhaler · Ottawa Heart Institute Research Corporation · Nicotine replacement therapy (NRT) · Smoking Cessation / Addiction Medicine
  Nicorette Inhaler delivers nicotine through inhalation to bind nicotinic acetylcholine receptors in the brain, reducing cravings and withdrawal symptoms during smoking cessation.
• Nicotine Patch + Nicotine Gum · University of Wisconsin, Madison · Nicotinic acetylcholine receptor agonist · Addiction Medicine / Smoking Cessation
  Nicotine binds to nicotinic acetylcholine receptors in the brain to reduce cravings and withdrawal symptoms during smoking cessation.
• Nicotine Replacement Therapy · Ottawa Hospital Research Institute · Nicotinic acetylcholine receptor agonist · Addiction Medicine / Smoking Cessation
  Nicotine replacement therapy delivers nicotine to the body through alternative routes (patches, gum, lozenges, nasal spray, or inhalers) to reduce withdrawal symptoms and cravings during smoking cessation.
• Nicotine Transdermal Patch · University of Southern California · Nicotinic acetylcholine receptor agonist · Addiction Medicine / Smoking Cessation
  Nicotine binds to nicotinic acetylcholine receptors in the central and peripheral nervous system, providing nicotine replacement to reduce withdrawal symptoms and cravings in tobacco users.
• Cytisinicline and exercise · Maimónides Biomedical Research Institute of Córdoba · Nicotinic acetylcholine receptor partial agonist · Addiction/Smoking Cessation
  Cytisinicline is a partial agonist of nicotinic acetylcholine receptors that reduces nicotine craving and withdrawal symptoms, combined with exercise to enhance smoking cessation outcomes.
• Nicotine replacement therapy sampling · The University of Hong Kong · Nicotinic receptor agonist · Addiction Medicine / Smoking Cessation
  Nicotine replacement therapy delivers nicotine through non-combustible routes to satisfy nicotine dependence and reduce withdrawal symptoms during smoking cessation.
• Nicotine Mini-Lozenge · University of Wisconsin, Madison · Nicotine replacement therapy (NRT) · Smoking Cessation / Addiction Medicine
  Nicotine mini-lozenges deliver nicotine through oral mucosal absorption to reduce cravings and withdrawal symptoms during smoking cessation.
• Nicotine patches · University of California, San Francisco · Nicotinic acetylcholine receptor agonist · Addiction Medicine / Smoking Cessation
  Nicotine patches deliver nicotine transdermally to bind nicotinic acetylcholine receptors in the brain, reducing cravings and withdrawal symptoms during smoking cessation.
• NicodermCQ · University of Chicago · Nicotine replacement therapy (NRT) · Smoking Cessation / Addiction Medicine
  NicodermCQ delivers nicotine transdermally to replace nicotine from cigarettes and reduce withdrawal symptoms during smoking cessation.
• nicotine patch plus nicotine gum/lozenge · University of Minnesota · Nicotine replacement therapy (NRT) combination · Smoking Cessation / Addiction Medicine
  Nicotine patches and gum/lozenges deliver nicotine through different routes to bind nicotinic acetylcholine receptors in the brain, reducing withdrawal symptoms and cravings during smoking cessation.
• Nicotine Patch and Nicotine Lozenge · University of Wisconsin, Madison · Nicotinic acetylcholine receptor agonist · Addiction Medicine / Smoking Cessation
  Nicotine binds to nicotinic acetylcholine receptors in the brain, providing nicotine replacement to reduce cravings and withdrawal symptoms during smoking cessation.
• NicoDerm CQ Patch · Chrono Therapeutics, Inc. · Nicotine replacement therapy (NRT) · Addiction Medicine / Smoking Cessation
  NicoDerm CQ delivers nicotine transdermally to replace nicotine from cigarettes and reduce withdrawal symptoms during smoking cessation.
• Nicotine Mini · University of Wisconsin, Madison · Nicotine replacement therapy · Smoking Cessation / Addiction Medicine
  Nicotine Mini is a nicotine replacement therapy product that delivers nicotine through a small, discrete oral form to reduce cravings and withdrawal symptoms in smokers attempting to quit.

Phase 3 pipeline (5)

• Nicotine Replacement Therapy Agent - Patches · NYU Langone Health · Nicotine replacement therapy agent · Addiction Medicine / Smoking Cessation
  Nicotine patches deliver nicotine transdermally to bind nicotinic acetylcholine receptors in the brain, reducing withdrawal symptoms and cravings during smoking cessation.
• Nicotine replacement therapy - nicotine gum · Iowa City Veterans Affairs Medical Center · Nicotinic acetylcholine receptor agonist · Addiction Medicine / Smoking Cessation
  Nicotine gum delivers nicotine through the oral mucosa to bind nicotinic acetylcholine receptors in the brain, reducing cravings and withdrawal symptoms during smoking cessation.
• Normal Nicotine Content Cigarettes · University of Minnesota · Addiction Medicine / Smoking Cessation
  Normal nicotine content cigarettes deliver standard levels of nicotine to study the relationship between nicotine exposure and smoking behavior or health outcomes in a controlled research setting.
• Nicotine Replacement Therapy Agent - Lozenges · NYU Langone Health · Nicotine replacement therapy · Addiction
  Lozenges release nicotine into the bloodstream to help manage withdrawal symptoms and cravings.
• Nicotine Replacement Therapy Agent - Gum · NYU Langone Health · Nicotine replacement therapy agent · Smoking Cessation / Addiction Medicine
  Nicotine gum delivers nicotine through oral mucosa absorption to replace nicotine from cigarettes and reduce withdrawal symptoms during smoking cessation.