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Nicorette Gum
Nicotine binds to nicotinic acetylcholine receptors in the brain, providing nicotine replacement to reduce cravings and withdrawal symptoms during smoking cessation.
Nicotine binds to nicotinic acetylcholine receptors in the brain, providing nicotine replacement to reduce cravings and withdrawal symptoms during smoking cessation. Used for Smoking cessation aid, Reduction of cigarette smoking.
At a glance
| Generic name | Nicorette Gum |
|---|---|
| Also known as | NRT |
| Sponsor | University of Miami |
| Drug class | Nicotinic acetylcholine receptor agonist |
| Target | Nicotinic acetylcholine receptors |
| Modality | Small molecule |
| Therapeutic area | Smoking Cessation / Addiction Medicine |
| Phase | FDA-approved |
Mechanism of action
Nicorette Gum delivers nicotine through the oral mucosa, bypassing the lungs and providing a slower, more controlled nicotine absorption compared to smoking. By activating nicotinic acetylcholine receptors, it alleviates withdrawal symptoms and reduces the rewarding effects of cigarette smoking, helping users quit. This allows smokers to gradually reduce nicotine dependence while managing behavioral and physical addiction.
Approved indications
- Smoking cessation aid
- Reduction of nicotine withdrawal symptoms
Common side effects
- Mouth and throat irritation
- Hiccups
- Dyspepsia
- Jaw soreness
- Nausea
Key clinical trials
- Pharmacokinetic and Subjective Effects of Heated Tobacco Products (NA)
- Using Nicotine to Reverse Age-related Auditory Processing Deficits (NA)
- Effect of Nicotine Gingival Fibroblast Intoxication on the Response of Periodontal Treatment (NA)
- Smoking Cessation and Menstrual Cycle Phase (PHASE4)
- Cytisine vs Nicotine Replacement Therapy (NA)
- Nordic Spirit Pouch Nicotine Pharmacokinetics Abuse Liability (PHASE1)
- ACT Lung Health Intervention: Phase Two (NA)
- iCanQuit Smoking Cessation Among Hispanic Adults (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Nicorette Gum CI brief — competitive landscape report
- Nicorette Gum updates RSS · CI watch RSS
- University of Miami portfolio CI