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Extended Duration Combination NRT
Extended Duration Combination NRT delivers multiple forms of nicotine replacement therapy over a prolonged period to reduce withdrawal symptoms and support smoking cessation.
Extended Duration Combination NRT delivers multiple forms of nicotine replacement therapy over a prolonged period to reduce withdrawal symptoms and support smoking cessation. Used for Smoking cessation support.
At a glance
| Generic name | Extended Duration Combination NRT |
|---|---|
| Sponsor | University of Wisconsin, Madison |
| Drug class | Nicotine replacement therapy (combination) |
| Target | Nicotinic acetylcholine receptors |
| Modality | Small molecule |
| Therapeutic area | Smoking Cessation / Addiction Medicine |
| Phase | FDA-approved |
Mechanism of action
This product combines different nicotine delivery modalities (such as patches, gum, or lozenges) designed to provide sustained nicotine replacement over an extended duration, addressing both the acute cravings and chronic withdrawal symptoms associated with smoking cessation. By maintaining more stable nicotine levels throughout the day and night, the combination approach aims to improve quit rates compared to single-modality NRT.
Approved indications
- Smoking cessation support
Common side effects
- Skin irritation (patch site)
- Mouth irritation (gum/lozenge)
- Nausea
- Dizziness
- Insomnia
Key clinical trials
- Cessation Screening Project (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |