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Nicotine Replacement Therapy Agent - Lozenges
Lozenges release nicotine into the bloodstream to help manage withdrawal symptoms and cravings.
Lozenges release nicotine into the bloodstream to help manage withdrawal symptoms and cravings. Used for Smoking cessation.
At a glance
| Generic name | Nicotine Replacement Therapy Agent - Lozenges |
|---|---|
| Sponsor | NYU Langone Health |
| Drug class | Nicotine replacement therapy |
| Target | Nicotinic acetylcholine receptors |
| Modality | Small molecule |
| Therapeutic area | Addiction |
| Phase | Phase 3 |
Mechanism of action
Nicotine replacement therapy (NRT) works by replacing the nicotine that the body is used to getting from cigarettes. Lozenges are one type of NRT that dissolves in the mouth to release a controlled amount of nicotine into the bloodstream, helping to reduce withdrawal symptoms and cravings.
Approved indications
- Smoking cessation
Common side effects
- Hiccups
- Mouth or throat irritation
- Nausea
Key clinical trials
- Smoking Cessation and Menstrual Cycle Phase (PHASE4)
- Cytisine vs Nicotine Replacement Therapy (NA)
- Auricular Stimulation for Nicotine Withdrawal in Psychiatric Inpatients (NA)
- E-Cigarettes for Harm Reduction in Smokers With Opioid Use Disorder (PHASE2)
- Combination Nicotine Replacement Therapy, Cytisine, or Varenicline for Smoking Cessation (PHASE4)
- STEPS: Substance Use Trial of E-cigarettes or Pharmacotherapy for Smoking (NA)
- Mindfulness-based Smoking Cessation Enhanced With Mobile Technology (NA)
- Neuroimaging Correlates and Feasibility of Transcranial Magnetic Stimulation (TMS) to Improve Smoking Cessation Outcomes in Veterans With Comorbid PTSD (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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