{"id":"nicotine-replacement-therapy-agent-lozenges","safety":{"commonSideEffects":[{"rate":"null","effect":"Hiccups"},{"rate":"null","effect":"Mouth or throat irritation"},{"rate":"null","effect":"Nausea"}]},"_chembl":{"chemblId":"CHEMBL3989563","moleculeType":"Small molecule","molecularWeight":"498.44"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Nicotine replacement therapy (NRT) works by replacing the nicotine that the body is used to getting from cigarettes. Lozenges are one type of NRT that dissolves in the mouth to release a controlled amount of nicotine into the bloodstream, helping to reduce withdrawal symptoms and cravings.","oneSentence":"Lozenges release nicotine into the bloodstream to help manage withdrawal symptoms and cravings.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:23:00.331Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Smoking cessation"}]},"trialDetails":[{"nctId":"NCT05515354","phase":"PHASE4","title":"Smoking Cessation and Menstrual Cycle Phase","status":"RECRUITING","sponsor":"Centre for Addiction and Mental Health","startDate":"2022-11-30","conditions":"Nicotine Dependence, Tobacco Smoking, Smoking Cessation","enrollment":1200},{"nctId":"NCT03249428","phase":"NA","title":"Cytisine vs Nicotine Replacement Therapy","status":"ENROLLING_BY_INVITATION","sponsor":"Ottawa Hospital Research Institute","startDate":"2025-11-04","conditions":"Tobacco Dependence, COPD Asthma, Mental Illness","enrollment":200},{"nctId":"NCT07466875","phase":"NA","title":"Auricular Stimulation for Nicotine Withdrawal in Psychiatric Inpatients","status":"NOT_YET_RECRUITING","sponsor":"Chiao-Chiao Liao","startDate":"2026-04-01","conditions":"Nicotine Dependence, Nicotine Withdrawal, Tobacco Use Disorder","enrollment":60},{"nctId":"NCT05722561","phase":"PHASE2","title":"E-Cigarettes for Harm Reduction in Smokers With Opioid Use Disorder","status":"RECRUITING","sponsor":"NYU Langone Health","startDate":"2024-08-08","conditions":"Opioid Use Disorder, Cigarette Smoking","enrollment":302},{"nctId":"NCT06832085","phase":"PHASE4","title":"Combination Nicotine Replacement Therapy, Cytisine, or Varenicline for Smoking Cessation","status":"RECRUITING","sponsor":"Ottawa Heart Institute Research Corporation","startDate":"2025-04-30","conditions":"Tobacco","enrollment":150},{"nctId":"NCT06922617","phase":"NA","title":"STEPS: Substance Use Trial of E-cigarettes or Pharmacotherapy for Smoking","status":"RECRUITING","sponsor":"Medical University of South Carolina","startDate":"2025-10-17","conditions":"Tobacco Use, Substance Use Disorders","enrollment":240},{"nctId":"NCT04965181","phase":"NA","title":"Mindfulness-based Smoking Cessation Enhanced With Mobile Technology","status":"COMPLETED","sponsor":"Georgia State University","startDate":"2021-07-01","conditions":"Cigarette Smoking","enrollment":504},{"nctId":"NCT05723588","phase":"PHASE2","title":"Neuroimaging Correlates and Feasibility of Transcranial Magnetic Stimulation (TMS) to Improve Smoking Cessation Outcomes in Veterans With Comorbid PTSD","status":"RECRUITING","sponsor":"VA Office of Research and Development","startDate":"2023-10-31","conditions":"Tobacco Use Disorder","enrollment":50},{"nctId":"NCT06290869","phase":"PHASE3","title":"Tobacco Education and Lung Health Study (TEAL)","status":"RECRUITING","sponsor":"Georgetown University","startDate":"2024-02-22","conditions":"Smoking Cessation","enrollment":1188},{"nctId":"NCT07099638","phase":"PHASE2","title":"Trial of Varenicline With Nicotine Lozenges and a Smartphone Medication Adherence Intervention for Smoking Cessation","status":"NOT_YET_RECRUITING","sponsor":"University of Oklahoma","startDate":"2026-03","conditions":"Smoking Cessation","enrollment":496},{"nctId":"NCT04525755","phase":"PHASE1, PHASE2","title":"STARS (Smoking Treatment And Remote Sampling) Study","status":"COMPLETED","sponsor":"Medical University of South Carolina","startDate":"2021-02-08","conditions":"Smoking, Smoking Cessation, Tobacco Smoking","enrollment":652},{"nctId":"NCT05790486","phase":"NA","title":"Take A Break - Rural","status":"RECRUITING","sponsor":"Wake Forest University Health Sciences","startDate":"2023-07-11","conditions":"Smoking, Smoking Behaviors, Smoking Cessation","enrollment":800},{"nctId":"NCT07220356","phase":"PHASE4","title":"C-Raven, a Virtual Tobacco Cessation Intervention in Residency Clinics","status":"RECRUITING","sponsor":"Johns Hopkins University","startDate":"2025-12-10","conditions":"Tobacco Dependence","enrollment":30},{"nctId":"NCT06545669","phase":"PHASE4","title":"C-Raven, a Virtual Tobacco Cessation Intervention in the Community","status":"COMPLETED","sponsor":"Johns Hopkins University","startDate":"2024-10-30","conditions":"Tobacco Dependence","enrollment":10},{"nctId":"NCT06534047","phase":"PHASE4","title":"Transcranial Magnetic Stimulation for Nicotine Dependence: An Effectiveness-Implementation Trial","status":"RECRUITING","sponsor":"Centre for Addiction and Mental Health","startDate":"2024-09-01","conditions":"Tobacco Use Disorder, Psychiatric Disorder, Nicotine Dependence","enrollment":40},{"nctId":"NCT03315910","phase":"PHASE4","title":"Implementing Tobacco Treatment in Low Dose CT Lung Cancer Screening Sites","status":"ACTIVE_NOT_RECRUITING","sponsor":"Memorial Sloan Kettering Cancer Center","startDate":"2017-10-10","conditions":"Smoking Cessation","enrollment":807},{"nctId":"NCT07148232","phase":"PHASE4","title":"Extended Intervention for Tobacco Use (EXIT) for People Experiencing Homelessness","status":"RECRUITING","sponsor":"University of California, San Francisco","startDate":"2025-11-14","conditions":"Tobacco Cessation, Tobacco Abstinence, Tobacco Use","enrollment":150},{"nctId":"NCT06169813","phase":"PHASE1","title":"E-cigarette Harm Reduction Among PLWHA in South Africa","status":"ACTIVE_NOT_RECRUITING","sponsor":"NYU Langone Health","startDate":"2025-04-15","conditions":"Tobacco Smoking","enrollment":106},{"nctId":"NCT06161675","phase":"NA","title":"Feasibility of Delivering VergeRx at FQHCs","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Virginia","startDate":"2024-09-23","conditions":"Tobacco Use Cessation","enrollment":100},{"nctId":"NCT05660525","phase":"NA","title":"Leveraging Community Pharmacists to Optimize Smoking Cessation Services for Rural Smokers in Appalachia","status":"RECRUITING","sponsor":"University of Virginia","startDate":"2024-03-06","conditions":"Smoking Cessation, Smoking, Cigarette, Smoking Reduction","enrollment":768},{"nctId":"NCT04604509","phase":"PHASE4","title":"Nicotine Replacement Therapy, Counseling, Varenicline, and Bupropion for Smoking Cessation, the PISCES I Trial","status":"RECRUITING","sponsor":"M.D. Anderson Cancer Center","startDate":"2020-08-04","conditions":"Cigarette Smoking-Related Carcinoma","enrollment":2010},{"nctId":"NCT05815199","phase":"NA","title":"E-cigarettes for Harm Reduction Among Smokers With Serious Mental Illness","status":"RECRUITING","sponsor":"NYU Langone Health","startDate":"2023-11-13","conditions":"Cigarette Smoking","enrollment":60},{"nctId":"NCT04199117","phase":"PHASE4","title":"Health Systems Reach Interventions Project","status":"COMPLETED","sponsor":"University of Wisconsin, Madison","startDate":"2020-03-11","conditions":"Smoking, Cigarette, Smoking Cessation","enrollment":210},{"nctId":"NCT06289192","phase":"PHASE4","title":"Testing C-Raven, a Virtual Tobacco Cessation Intervention, in the Community","status":"COMPLETED","sponsor":"Johns Hopkins University","startDate":"2024-04-30","conditions":"Tobacco Dependence","enrollment":5},{"nctId":"NCT04694846","phase":"NA","title":"Effectiveness of an Enhanced Tobacco Intervention Protocol Compared to Standard Treatment in Helping Head and Neck and Lung Cancer Patients Starting Treatment to Reduce Cigarette Use","status":"COMPLETED","sponsor":"Thomas Jefferson University","startDate":"2020-08-19","conditions":"Lung Non-Small Cell Carcinoma, Head and Neck Squamous Cell Carcinoma","enrollment":19},{"nctId":"NCT07059377","phase":"PHASE3","title":"Semaglutide for Smoking Cessation in Patients With Diabetes","status":"NOT_YET_RECRUITING","sponsor":"Ottawa Heart Institute Research Corporation","startDate":"2025-09","conditions":"Diabetes Mellitus, Type 2, Nicotine Addiction, Tobacco Dependence","enrollment":100},{"nctId":"NCT05513872","phase":"PHASE1, PHASE2","title":"Overcoming Nicotine Dependence to Enable Quitting","status":"RECRUITING","sponsor":"Rush University Medical Center","startDate":"2023-03-24","conditions":"Tobacco Use, Smoking Cessation, Smoking Behaviors","enrollment":780},{"nctId":"NCT05351606","phase":"PHASE4","title":"Integrating Tobacco Use Cessation Into HIV Care and Treatment in Kisumu County, Kenya","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2023-05-16","conditions":"Tobacco Use Cessation, Tobacco Use","enrollment":580},{"nctId":"NCT05154669","phase":"PHASE3","title":"Integrating Financial Coaching and Smoking Cessation Coaching","status":"RECRUITING","sponsor":"NYU Langone Health","startDate":"2022-12-08","conditions":"Smoking","enrollment":488},{"nctId":"NCT06763536","phase":"NA","title":"Oral Nicotine Pouches Versus Nicotine Replacement Therapy to Reduce Cigarette Use for Smokers in Rural Appalachia","status":"RECRUITING","sponsor":"Ohio State University Comprehensive Cancer Center","startDate":"2025-06-13","conditions":"Cigarette Smoking-Related Carcinoma","enrollment":1000},{"nctId":"NCT06051474","phase":"PHASE4","title":"Treating Caregivers Who Smoke at AFCH","status":"COMPLETED","sponsor":"University of Wisconsin, Madison","startDate":"2024-03-05","conditions":"Smoking, Smoking Cessation","enrollment":23},{"nctId":"NCT06931054","phase":"NA","title":"Combination of Acupuncture, Auricular Acupressure and Nicotine Replacement Therapy for Smoking Cessation","status":"RECRUITING","sponsor":"The University of Hong Kong","startDate":"2025-05-05","conditions":"Smoking","enrollment":270},{"nctId":"NCT05130788","phase":"NA","title":"WeChat Quit Coach Pilot Study","status":"COMPLETED","sponsor":"NYU Langone Health","startDate":"2022-02-10","conditions":"Smoking Cessation","enrollment":150},{"nctId":"NCT04994444","phase":"PHASE2, PHASE3","title":"Preloading With Nicotine Replacement Therapy in HIV-positive Smokers to Improve Self-Efficacy and Quit Attempts","status":"COMPLETED","sponsor":"Brown University","startDate":"2021-09-01","conditions":"Tobacco Use Cessation","enrollment":49},{"nctId":"NCT06260683","phase":"NA","title":"A Comprehensive Evaluation of Tobacco-Flavored vs. Non-Tobacco Flavored E-cigarettes on Smoking Behavior","status":"RECRUITING","sponsor":"Ohio State University Comprehensive Cancer Center","startDate":"2024-04-10","conditions":"Cigarette Smoking-Related Carcinoma","enrollment":1500},{"nctId":"NCT06088862","phase":"PHASE3","title":"Evaluate Harm Reduction Products as a Second Line Intervention for Adult Smokers Who Do Not Quit With NRT","status":"TERMINATED","sponsor":"Rose Research Center, LLC","startDate":"2023-12-27","conditions":"Smoking Cessation, Harm Reduction","enrollment":4},{"nctId":"NCT03808818","phase":"NA","title":"Implementing a Virtual Tobacco Treatment for Cancer Patients in Community Oncology Practices","status":"COMPLETED","sponsor":"ECOG-ACRIN Cancer Research Group","startDate":"2019-08-01","conditions":"Carcinoma In Situ, Current Smoker, Malignant Neoplasm","enrollment":306},{"nctId":"NCT04887558","phase":"PHASE2","title":"Mobile App for Smoking Cessation and Mental Health","status":"SUSPENDED","sponsor":"University of Oklahoma","startDate":"2021-12-14","conditions":"Smoking Cessation, Mental Illness","enrollment":75},{"nctId":"NCT06350175","phase":"PHASE4","title":"Emergency Department Management of Tobacco Use Disorder","status":"WITHDRAWN","sponsor":"West Virginia University","startDate":"2024-08","conditions":"Tobacco Use Disorder, Tobacco Use Cessation","enrollment":""},{"nctId":"NCT06745154","phase":"NA","title":"Evaluating the Impact of Quitting Using Executive Function Strategy Training (QUEST) on Smoking Cessation in Homeless Young Adult Smokers","status":"COMPLETED","sponsor":"Ohio State University Comprehensive Cancer Center","startDate":"2023-06-26","conditions":"Cigarette Smoking-Related Carcinoma","enrollment":27},{"nctId":"NCT02823028","phase":"PHASE2","title":"Twitter-enabled Mobile Messaging for Smoking Relapse Prevention (Tweet2Quit)","status":"COMPLETED","sponsor":"University of California, Irvine","startDate":"2016-10","conditions":"Smoking Cessation","enrollment":980},{"nctId":"NCT05525078","phase":"NA","title":"Quit or Switch: E-cigarette Study","status":"COMPLETED","sponsor":"Medical University of South Carolina","startDate":"2022-08-01","conditions":"Tobacco Use","enrollment":30},{"nctId":"NCT06063421","phase":"NA","title":"Comparison of Nicotine Replacement Therapy and Electronic Cigarettes for Smoking Cessation in Pakistan","status":"NOT_YET_RECRUITING","sponsor":"Strategic Health Research Limited","startDate":"2024-06-01","conditions":"Smoking Cessation, Electronic Cigarette Use","enrollment":438},{"nctId":"NCT04297332","phase":"NA","title":"Episodic Future Thinking and Future Thinking Priming for Smoking Cessation","status":"TERMINATED","sponsor":"Roswell Park Cancer Institute","startDate":"2020-01-01","conditions":"Tobacco-Related Carcinoma","enrollment":26},{"nctId":"NCT03722966","phase":"PHASE2","title":"Effectiveness of Combination Varenicline and Oral Nicotine Replacement Therapy (COMBO)","status":"TERMINATED","sponsor":"University of Oklahoma","startDate":"2020-01-07","conditions":"Smoking Cessation","enrollment":34},{"nctId":"NCT04286295","phase":"NA","title":"Cytisine Compared to Combination NRT in Relapsed Smokers","status":"TERMINATED","sponsor":"Ottawa Heart Institute Research Corporation","startDate":"2022-03-14","conditions":"Smoking Cessation, Coronary Artery Disease","enrollment":13},{"nctId":"NCT00888459","phase":"PHASE2","title":"A Pilot Study Evaluating Nicotine Lozenges and Self Help","status":"COMPLETED","sponsor":"Mayo Clinic","startDate":"2008-04","conditions":"Smokeless Tobacco Use","enrollment":60},{"nctId":"NCT03691350","phase":"EARLY_PHASE1","title":"Bronchoscopy in Determining the Effect of E-Cigarette Smoking on Biomarkers in the Lungs","status":"UNKNOWN","sponsor":"Ohio State University Comprehensive Cancer Center","startDate":"2018-09-17","conditions":"Cigarette Smoker, Current Every Day Smoker","enrollment":239},{"nctId":"NCT05740098","phase":"NA","title":"Financial Incentives for Smoking Cessation Among Mothers","status":"COMPLETED","sponsor":"University of Vermont","startDate":"2015-06","conditions":"Cigarette Smoking","enrollment":198},{"nctId":"NCT04135937","phase":"PHASE4","title":"Mobile Evidence-Based Smoking Cessation for Veterans Living With HIV (MESH)","status":"COMPLETED","sponsor":"VA Office of Research and Development","startDate":"2019-11-18","conditions":"Human Immunodeficiency Virus, Smoking","enrollment":12},{"nctId":"NCT03626064","phase":"NA","title":"The PROMPT Pilot Study","status":"COMPLETED","sponsor":"Ottawa Hospital Research Institute","startDate":"2014-06","conditions":"Tobacco Use Disorder, Tobacco Dependence, Tobacco Use Cessation","enrollment":80},{"nctId":"NCT02721082","phase":"PHASE4","title":"Changing the Default for Tobacco Treatment","status":"COMPLETED","sponsor":"University of Kansas Medical Center","startDate":"2016-09-01","conditions":"Tobacco Use Cessation","enrollment":1000},{"nctId":"NCT03111537","phase":"NA","title":"Methods Project 4: Clinical Trial - Amended","status":"COMPLETED","sponsor":"University of Minnesota","startDate":"2015-05","conditions":"Tobacco Smoking","enrollment":264},{"nctId":"NCT04461288","phase":"NA","title":"Engaging Sexual and Gender Minority Cigarette Smokers Into Social Media-based Treatment","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2020-05-01","conditions":"Smoking Cessation, Nicotine Dependence, Tobacco Use","enrollment":121},{"nctId":"NCT02973425","phase":"NA","title":"Take a Break (TAB): mHealth-assisted Skills Building Challenge for Unmotivated Smokers","status":"COMPLETED","sponsor":"University of Massachusetts, Worcester","startDate":"2016-11-07","conditions":"Smoking Cessation","enrollment":433},{"nctId":"NCT03690596","phase":"NA","title":"Smoking Relapse Prevention Via Just-in-Time-Adaptive Interventions","status":"UNKNOWN","sponsor":"Meharry Medical College","startDate":"2019-04-16","conditions":"Smoking Cessation","enrollment":94},{"nctId":"NCT02050308","phase":"PHASE3","title":"Web-based Smoking Cessation Program for Tribal College Students","status":"COMPLETED","sponsor":"Won Choi, PhD, MPH","startDate":"2015-05","conditions":"Smoking Cessation","enrollment":251},{"nctId":"NCT00356993","phase":"NA","title":"Phase I Study: Stop Smoking Therapy for Ontario Patients (STOP)","status":"COMPLETED","sponsor":"Centre for Addiction and Mental Health","startDate":"2005-10","conditions":"Smoking","enrollment":6009},{"nctId":"NCT02995915","phase":"PHASE4","title":"Mobile Contingency Management for Concurrent Abstinence From Alcohol and Smoking","status":"COMPLETED","sponsor":"Duke University","startDate":"2016-11","conditions":"Smoking Cessation, Alcohol Drinking","enrollment":45},{"nctId":"NCT04114526","phase":"NA","title":"Durham Housing Authority (DHA) Community Health Advisor (CHA) Smoking Cessation Project","status":"COMPLETED","sponsor":"Duke University","startDate":"2019-07-19","conditions":"Smoking Cessation","enrollment":31},{"nctId":"NCT03799315","phase":"NA","title":"Jail-Based Use of Smoking Cessation Treatment Study","status":"COMPLETED","sponsor":"Hennepin Healthcare Research Institute","startDate":"2019-01-14","conditions":"Tobacco Use","enrollment":66},{"nctId":"NCT03620708","phase":"PHASE4","title":"Tobacco and Socioeconomic Disadvantage","status":"COMPLETED","sponsor":"Rutgers, The State University of New Jersey","startDate":"2018-05-30","conditions":"Tobacco Smoking","enrollment":58},{"nctId":"NCT00469079","phase":"PHASE2","title":"Health Effects of SLT, Cigarette Smoking, and New Tobacco Products","status":"COMPLETED","sponsor":"University of Minnesota","startDate":"2007-01","conditions":"Nicotine Dependence","enrollment":130},{"nctId":"NCT02096029","phase":"NA","title":"Tobacco Intervention in Primary Care Treatment Opportunities for Providers","status":"COMPLETED","sponsor":"Medical University of South Carolina","startDate":"2014-07","conditions":"Smoking, Smoking Cessation","enrollment":1278},{"nctId":"NCT02420015","phase":"PHASE4","title":"Mobile Health Technology to Enhance Abstinence in Smokers With Schizophrenia","status":"COMPLETED","sponsor":"Duke University","startDate":"2017-03-27","conditions":"Schizophrenia, Cigarette Smoking","enrollment":35},{"nctId":"NCT02244918","phase":"PHASE4","title":"Informing Tobacco Treatment Guidelines for African American Non-Daily Smokers","status":"COMPLETED","sponsor":"University of Kansas Medical Center","startDate":"2015-05","conditions":"Smoking Cessation","enrollment":278},{"nctId":"NCT01901848","phase":"PHASE2, PHASE3","title":"CPT and Smoking Cessation","status":"COMPLETED","sponsor":"VA Office of Research and Development","startDate":"2013-12-11","conditions":"Stress Disorders, Post-Traumatic, Smoking","enrollment":69},{"nctId":"NCT01393392","phase":"PHASE1","title":"Developing a Smoking Cessation Intervention for Methadone Maintained Smokers","status":"COMPLETED","sponsor":"Rutgers, The State University of New Jersey","startDate":"2011-10","conditions":"Nicotine Dependence, Opiate Dependence","enrollment":87},{"nctId":"NCT02562521","phase":"PHASE4","title":"A Smoking Cessation Intervention for Yale Dining Employees","status":"COMPLETED","sponsor":"Yale University","startDate":"2015-09","conditions":"Smoking Cessation","enrollment":25},{"nctId":"NCT01544153","phase":"NA","title":"Improving Adherence to Web-Based Cessation Programs: A Social Network Approach","status":"COMPLETED","sponsor":"Truth Initiative","startDate":"2012-02","conditions":"Smoking Cessation","enrollment":5292},{"nctId":"NCT02148445","phase":"PHASE3","title":"Smoking Cessation Versus Long-term Nicotine Replacement Among High-risk Smokers","status":"COMPLETED","sponsor":"University of Kansas Medical Center","startDate":"2014-05","conditions":"Smoking, Pulmonary Disease, Chronic Obstructive, Tobacco Use Disorder","enrollment":398},{"nctId":"NCT01791803","phase":"NA","title":"Smoking Cessation After Hospitalization for a Cardiopulmonary Illness","status":"COMPLETED","sponsor":"North Shore Medical Center","startDate":"2006-01","conditions":"Smoking Cessation","enrollment":164},{"nctId":"NCT01989923","phase":"NA","title":"Smoking Cessation in Women With Gynecological Conditions","status":"COMPLETED","sponsor":"University of Oklahoma","startDate":"2013-06","conditions":"Cervical Dysplasia","enrollment":31},{"nctId":"NCT00218283","phase":"PHASE2","title":"Nicotine Lozenge to Reduce Smokeless Tobacco Use","status":"COMPLETED","sponsor":"National Institute on Drug Abuse (NIDA)","startDate":"2005-01","conditions":"Tobacco Use Disorder","enrollment":100},{"nctId":"NCT02491086","phase":"NA","title":"Motivating Smokers at Outdoor Public Smoking Hotspots to Have Quit Attempt With Nicotine Replacement Therapy Sampling","status":"COMPLETED","sponsor":"The University of Hong Kong","startDate":"2015-07","conditions":"Smoking Cessation","enrollment":100},{"nctId":"NCT02357888","phase":"PHASE2","title":"Assessment of V0018 2.5 mg Effect on Craving","status":"COMPLETED","sponsor":"Pierre Fabre Medicament","startDate":"2015-02","conditions":"Healthy Highly Dependant Smokers","enrollment":45},{"nctId":"NCT01990079","phase":"NA","title":"Use of Technological Advances to Prevent Smoking Relapse Among Smokers With PTSD","status":"COMPLETED","sponsor":"Duke University","startDate":"2013-12","conditions":"PTSD, Smoking","enrollment":15},{"nctId":"NCT01789710","phase":"NA","title":"Contingency Management for Smoking Cessation in Homeless Smokers","status":"COMPLETED","sponsor":"Duke University","startDate":"2013-01","conditions":"Smoking, Homeless Persons","enrollment":25},{"nctId":"NCT01123967","phase":"NA","title":"Offering Proactive Tobacco Treatment","status":"COMPLETED","sponsor":"University of Minnesota","startDate":"2011-02","conditions":"Tobacco Use Cessation","enrollment":2500},{"nctId":"NCT02359201","phase":"PHASE2","title":"Assessment of V0018 1.5 mg Effect on Craving","status":"COMPLETED","sponsor":"Pierre Fabre Medicament","startDate":"2015-02","conditions":"Smoking","enrollment":30},{"nctId":"NCT00224419","phase":"PHASE4","title":"Testing Pharmacological Therapies for Pregnant Smokers","status":"TERMINATED","sponsor":"Duke University","startDate":"2003-06","conditions":"Smoking, Pregnancy","enrollment":181},{"nctId":"NCT00108342","phase":"NA","title":"Nicotine Delivery Systems: Research & Treatment","status":"TERMINATED","sponsor":"US Department of Veterans Affairs","startDate":"2007-10","conditions":"Smoking","enrollment":25},{"nctId":"NCT01084707","phase":"NA","title":"Multiple-dose Nicotine Pharmacokinetics With a New Oral Nicotine Replacement Product.","status":"COMPLETED","sponsor":"McNeil AB","startDate":"2009-01","conditions":"Tobacco Dependence","enrollment":40},{"nctId":"NCT01075659","phase":"PHASE2","title":"Early Effects of a New Oral Nicotine Replacement Product and NiQuitin™ Lozenge","status":"COMPLETED","sponsor":"McNeil AB","startDate":"2010-02","conditions":"Smoking Cessation","enrollment":200},{"nctId":"NCT01227720","phase":"NA","title":"Comparative Pharmacokinetic Study of New Oral Nicotine Replacement Therapy Products.","status":"COMPLETED","sponsor":"McNeil AB","startDate":"2009-08","conditions":"Tobacco Dependence","enrollment":104},{"nctId":"NCT00706979","phase":"NA","title":"A Novel Treatment to Boost Quit Attempts and Cessation Among Unmotivated Smokers","status":"COMPLETED","sponsor":"Medical University of South Carolina","startDate":"2008-09","conditions":"Smoking, Smoking Cessation","enrollment":849}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":9,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Nicotine Replacement Therapy Agent - Lozenges","genericName":"Nicotine Replacement Therapy Agent - Lozenges","companyName":"NYU Langone Health","companyId":"nyu-langone-health","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Lozenges release nicotine into the bloodstream to help manage withdrawal symptoms and cravings. Used for Smoking cessation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}