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Nicotine Replacement Therapy Agent - Gum
Nicotine gum delivers nicotine through oral mucosa absorption to replace nicotine from cigarettes and reduce withdrawal symptoms during smoking cessation.
Nicotine gum delivers nicotine through oral mucosa absorption to replace nicotine from cigarettes and reduce withdrawal symptoms during smoking cessation. Used for Smoking cessation aid, Reduction of nicotine withdrawal symptoms in smokers attempting to quit.
At a glance
| Generic name | Nicotine Replacement Therapy Agent - Gum |
|---|---|
| Sponsor | NYU Langone Health |
| Drug class | Nicotine replacement therapy agent |
| Target | Nicotinic acetylcholine receptors |
| Modality | Small molecule |
| Therapeutic area | Smoking Cessation / Addiction Medicine |
| Phase | Phase 3 |
Mechanism of action
Nicotine binds to nicotinic acetylcholine receptors in the central nervous system, mimicking the effects of inhaled nicotine from tobacco. By providing a controlled dose of nicotine without the harmful combustion byproducts of smoking, it reduces cravings and withdrawal symptoms while allowing behavioral modification. This allows smokers to gradually reduce nicotine dependence through dose tapering.
Approved indications
- Smoking cessation aid
- Reduction of nicotine withdrawal symptoms in smokers attempting to quit
Common side effects
- Mouth irritation
- Hiccups
- Nausea
- Jaw soreness
- Indigestion
- Headache
Key clinical trials
- Smoking Cessation and Menstrual Cycle Phase (PHASE4)
- Cytisine vs Nicotine Replacement Therapy (NA)
- Auricular Stimulation for Nicotine Withdrawal in Psychiatric Inpatients (NA)
- Combination Nicotine Replacement Therapy, Cytisine, or Varenicline for Smoking Cessation (PHASE4)
- Neuroimaging Correlates and Feasibility of Transcranial Magnetic Stimulation (TMS) to Improve Smoking Cessation Outcomes in Veterans With Comorbid PTSD (PHASE2)
- The Efficacy of Combining Music Intervention With Nicotine Replacement Therapy to Reduce Smoking Craving, Among Healthcare Professionals Who Are Trying to Quit. (NA)
- C-Raven, a Virtual Tobacco Cessation Intervention in Residency Clinics (PHASE4)
- C-Raven, a Virtual Tobacco Cessation Intervention in the Community (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |