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Nicotine replacement therapy sampling
Nicotine replacement therapy delivers nicotine through non-combustible routes to satisfy nicotine dependence and reduce withdrawal symptoms during smoking cessation.
Nicotine replacement therapy delivers nicotine through non-combustible routes to satisfy nicotine dependence and reduce withdrawal symptoms during smoking cessation. Used for Smoking cessation aid, Reduction of nicotine withdrawal symptoms.
At a glance
| Generic name | Nicotine replacement therapy sampling |
|---|---|
| Also known as | NRT sample, Nicoderm, Nicorette, Nicotine Replacement Therapy |
| Sponsor | The University of Hong Kong |
| Drug class | Nicotinic receptor agonist |
| Target | Nicotinic acetylcholine receptors |
| Modality | Small molecule |
| Therapeutic area | Addiction Medicine / Smoking Cessation |
| Phase | FDA-approved |
Mechanism of action
Nicotine binds to nicotinic acetylcholine receptors in the central and peripheral nervous system, mimicking the effects of inhaled nicotine from cigarettes. By providing controlled nicotine doses without the harmful combustion byproducts of tobacco smoke, NRT reduces cravings and withdrawal symptoms, facilitating smoking cessation. The therapy is typically used as part of a comprehensive smoking cessation program that may include behavioral support.
Approved indications
- Smoking cessation aid
- Reduction of nicotine withdrawal symptoms
Common side effects
- Nausea
- Dizziness
- Headache
- Insomnia
- Irritability
- Local skin irritation (patch formulation)
- Mouth/throat irritation (gum/lozenge formulation)
Key clinical trials
- STARS (Smoking Treatment And Remote Sampling) Study (PHASE1, PHASE2)
- Take A Break - Rural (NA)
- Catalyzing Cigarette Smoking Cessation Through Harm Reduction Sampling Among People Unmotivated to Quit (NA)
- Evaluation of Cessation Preferences of Menthol Smoker (NA)
- Overcoming Nicotine Dependence to Enable Quitting (PHASE1, PHASE2)
- Oral Nicotine Pouches Versus Nicotine Replacement Therapy to Reduce Cigarette Use for Smokers in Rural Appalachia (NA)
- Smoking Cessation for Fathers of Sick Children (NA)
- BREATHE 2 Clinic Stop-Smoking Treatment Outreach Study (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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