{"id":"nicotine-replacement-therapy-sampling","safety":{"commonSideEffects":[{"rate":"10-20","effect":"Nausea"},{"rate":"5-15","effect":"Dizziness"},{"rate":"5-10","effect":"Headache"},{"rate":"10-20","effect":"Insomnia"},{"rate":"5-10","effect":"Irritability"},{"rate":"15-25","effect":"Local skin irritation (patch formulation)"},{"rate":"10-20","effect":"Mouth/throat irritation (gum/lozenge formulation)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Nicotine binds to nicotinic acetylcholine receptors in the central and peripheral nervous system, mimicking the effects of inhaled nicotine from cigarettes. By providing controlled nicotine doses without the harmful combustion byproducts of tobacco smoke, NRT reduces cravings and withdrawal symptoms, facilitating smoking cessation. The therapy is typically used as part of a comprehensive smoking cessation program that may include behavioral support.","oneSentence":"Nicotine replacement therapy delivers nicotine through non-combustible routes to satisfy nicotine dependence and reduce withdrawal symptoms during smoking cessation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:41:42.252Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Smoking cessation aid"},{"name":"Reduction of nicotine withdrawal symptoms"}]},"trialDetails":[{"nctId":"NCT04525755","phase":"PHASE1, PHASE2","title":"STARS (Smoking Treatment And Remote Sampling) Study","status":"COMPLETED","sponsor":"Medical University of South Carolina","startDate":"2021-02-08","conditions":"Smoking, Smoking Cessation, Tobacco Smoking","enrollment":652},{"nctId":"NCT05790486","phase":"NA","title":"Take A Break - Rural","status":"RECRUITING","sponsor":"Wake Forest University Health 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Affairs","startDate":"2007-10","conditions":"Smoking","enrollment":25}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":17,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["NRT sample","Nicoderm, Nicorette","Nicotine Replacement Therapy"],"phase":"marketed","status":"active","brandName":"Nicotine replacement therapy sampling","genericName":"Nicotine replacement therapy sampling","companyName":"The University of Hong Kong","companyId":"the-university-of-hong-kong","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Nicotine replacement therapy delivers nicotine through non-combustible routes to satisfy nicotine dependence and reduce withdrawal symptoms during smoking cessation. Used for Smoking cessation aid, Reduction of nicotine withdrawal symptoms.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}