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Pre-Quit Nicotine Gum
Pre-Quit Nicotine Gum delivers nicotine orally to reduce withdrawal symptoms and cravings during smoking cessation.
Pre-Quit Nicotine Gum delivers nicotine orally to reduce withdrawal symptoms and cravings during smoking cessation. Used for Smoking cessation aid.
At a glance
| Generic name | Pre-Quit Nicotine Gum |
|---|---|
| Sponsor | University of Wisconsin, Madison |
| Drug class | Nicotine replacement therapy |
| Target | Nicotinic acetylcholine receptors |
| Modality | Small molecule |
| Therapeutic area | Smoking Cessation / Addiction Medicine |
| Phase | FDA-approved |
Mechanism of action
The gum formulation allows for controlled, gradual release of nicotine that is absorbed through the oral mucosa, providing a substitute source of nicotine independent of cigarettes. This reduces the severity of withdrawal symptoms (irritability, anxiety, difficulty concentrating) and cravings that typically occur when smokers attempt to quit. By maintaining some nicotine exposure while eliminating the harmful combustion products of cigarettes, it facilitates the behavioral transition away from smoking.
Approved indications
- Smoking cessation aid
Common side effects
- Mouth and throat irritation
- Hiccups
- Dyspepsia
- Nausea
- Jaw soreness
Key clinical trials
- Smoking Cessation and Menstrual Cycle Phase (PHASE4)
- Varenicline for Smoking Reduction in Veterans Not Ready To Quit (PHASE4)
- Transcranial Magnetic Stimulation for Nicotine Dependence: An Effectiveness-Implementation Trial (PHASE4)
- Health Systems Reach Interventions Project (PHASE4)
- Evaluating Smoking Cessation Interventions for PWH in South Africa (PHASE2, PHASE3)
- Preloading With Nicotine Replacement Therapy in HIV-positive Smokers to Improve Self-Efficacy and Quit Attempts (PHASE2, PHASE3)
- Using Machine Learning to Develop Just-in-Time Adaptive Interventions for Smoking Cessation (NA)
- Tobacco Treatment for Employable Californians, Total IMPACT Study (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Pre-Quit Nicotine Gum CI brief — competitive landscape report
- Pre-Quit Nicotine Gum updates RSS · CI watch RSS
- University of Wisconsin, Madison portfolio CI