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Patch, Nicotine
Nicotine binds to nicotinic acetylcholine receptors in the central and peripheral nervous system to reduce cravings and withdrawal symptoms during smoking cessation.
Nicotine binds to nicotinic acetylcholine receptors in the central and peripheral nervous system to reduce cravings and withdrawal symptoms during smoking cessation. Used for Smoking cessation aid.
At a glance
| Generic name | Patch, Nicotine |
|---|---|
| Sponsor | Assistance Publique - Hôpitaux de Paris |
| Drug class | Nicotinic acetylcholine receptor agonist |
| Target | Nicotinic acetylcholine receptors |
| Modality | Small molecule |
| Therapeutic area | Addiction Medicine / Smoking Cessation |
| Phase | FDA-approved |
Mechanism of action
Nicotine patches deliver nicotine transdermally at a controlled rate, maintaining steady plasma levels that satisfy nicotine dependence without the combustion products of cigarettes. By occupying nicotinic acetylcholine receptors, nicotine reduces the reward-seeking behavior and withdrawal symptoms associated with smoking cessation, facilitating abstinence.
Approved indications
- Smoking cessation aid
Common side effects
- Skin irritation at patch site
- Headache
- Nausea
- Dizziness
- Sleep disturbances
- Vivid dreams
Key clinical trials
- Partnering With Food Bank to Provide Tobacco Treatment to Underserved Smokers (NA)
- Defining Neurobiological Links Between Substance Use and Mental Illness (NA)
- Exenatide for Smoking Cessation and Prevention of Weight Gain (PHASE2)
- A Study Of Vagal Nerve Stimulation In Conjunction With NRT For Smoking Cessation (PHASE2, PHASE3)
- Smoking Cessation and Menstrual Cycle Phase (PHASE4)
- Cytisine vs Nicotine Replacement Therapy (NA)
- ACT Lung Health Intervention: Phase Two (NA)
- iCanQuit Smoking Cessation Among Hispanic Adults (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Patch, Nicotine CI brief — competitive landscape report
- Patch, Nicotine updates RSS · CI watch RSS
- Assistance Publique - Hôpitaux de Paris portfolio CI