Last reviewed 2026-04-22 · How we verify

Nicoderm Transdermal Patch

Nicotine binds to nicotinic acetylcholine receptors in the central nervous system to reduce cravings and withdrawal symptoms during smoking cessation.

Nicotine binds to nicotinic acetylcholine receptors in the central nervous system to reduce cravings and withdrawal symptoms during smoking cessation. Used for Smoking cessation aid for nicotine dependence.

At a glance

Mechanism of action

Nicoderm delivers nicotine transdermally at a controlled rate, bypassing the rapid peaks and valleys of cigarette smoking. By occupying nicotinic acetylcholine receptors, it satisfies the brain's nicotine dependence while allowing patients to gradually reduce their nicotine intake through stepwise dose reduction. This approach reduces withdrawal symptoms and cravings, facilitating successful smoking cessation.

Approved indications

• Smoking cessation aid for nicotine dependence

Common side effects

• Skin irritation at patch application site
• Headache
• Nausea
• Dizziness
• Sleep disturbances
• Vivid dreams

Key clinical trials

• iCanQuit Smoking Cessation Among Hispanic Adults (PHASE3)
• Project DEDUCE: Digital Envirotyping to Develop Understanding of Cigarette Smoking and the Environment (PHASE4)
• STEPS: Substance Use Trial of E-cigarettes or Pharmacotherapy for Smoking (NA)
• Comparing Two Behavioral Approaches to Quitting Smoking in Mental Health Settings (NA)
• Effectiveness of an Integrated Treatment to Address Smoking Cessation and Anxiety/ Depression in People Living With HIV (NA)
• Varenicline and Combined NRT for Smoking Cessation (PHASE4)
• Depressed Mood Improvement Through Nicotine Dosing-3 (Depressed MIND3) Extension (PHASE2)
• Depressed Mood Improvement Through Nicotine Dosing 3 (PHASE2)

Primary sources

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