Last reviewed 2026-04-22 · How we verify

Nicotine Patch and Nicotine Lozenge

Nicotine binds to nicotinic acetylcholine receptors in the brain, providing nicotine replacement to reduce cravings and withdrawal symptoms during smoking cessation.

Nicotine binds to nicotinic acetylcholine receptors in the brain, providing nicotine replacement to reduce cravings and withdrawal symptoms during smoking cessation. Used for Smoking cessation aid, Reduction of nicotine withdrawal symptoms.

At a glance

Mechanism of action

Nicotine is an alkaloid that acts as an agonist at nicotinic acetylcholine receptors, particularly in the central nervous system. By delivering nicotine through transdermal patches or oral lozenges rather than cigarette smoke, these formulations satisfy nicotine dependence while avoiding the harmful combustion byproducts of tobacco. This reduces withdrawal symptoms and cravings, supporting smoking cessation efforts.

Approved indications

• Smoking cessation aid
• Reduction of nicotine withdrawal symptoms

Common side effects

• Skin irritation (patch)
• Mouth irritation (lozenge)
• Nausea
• Headache
• Dizziness
• Insomnia

Key clinical trials

• Partnering With Food Bank to Provide Tobacco Treatment to Underserved Smokers (NA)
• Smoking Cessation and Menstrual Cycle Phase (PHASE4)
• Cytisine vs Nicotine Replacement Therapy (NA)
• ACT Lung Health Intervention: Phase Two (NA)
• iCanQuit Smoking Cessation Among Hispanic Adults (PHASE3)
• Varenicline for Smoking Reduction in Veterans Not Ready To Quit (PHASE4)
• Auricular Stimulation for Nicotine Withdrawal in Psychiatric Inpatients (NA)
• E-Cigarettes for Harm Reduction in Smokers With Opioid Use Disorder (PHASE2)

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.