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Nicotine Mini-Lozenge for 11 Months
Nicotine binds to nicotinic acetylcholine receptors in the brain to reduce cravings and withdrawal symptoms during smoking cessation.
Nicotine binds to nicotinic acetylcholine receptors in the brain to reduce cravings and withdrawal symptoms during smoking cessation. Used for Smoking cessation aid for up to 11 months of treatment.
At a glance
| Generic name | Nicotine Mini-Lozenge for 11 Months |
|---|---|
| Also known as | Nicotine Mini-Lozenge |
| Sponsor | University of Wisconsin, Madison |
| Drug class | Nicotinic acetylcholine receptor agonist; Nicotine replacement therapy (NRT) |
| Target | Nicotinic acetylcholine receptors |
| Modality | Small molecule |
| Therapeutic area | Smoking Cessation / Addiction Medicine |
| Phase | FDA-approved |
Mechanism of action
Nicotine is a nicotinic acetylcholine receptor agonist that mimics the effects of nicotine from cigarettes, thereby reducing the intensity of withdrawal symptoms and cravings when a smoker quits. The mini-lozenge formulation allows for flexible, on-demand dosing to manage breakthrough cravings throughout the day. This approach helps maintain abstinence by providing nicotine replacement without the harmful combustion products of tobacco smoke.
Approved indications
- Smoking cessation aid
Common side effects
- Mouth irritation
- Hiccups
- Nausea
- Headache
- Insomnia
Key clinical trials
- Health Systems Reach Interventions Project (PHASE4)
- Motivation Project: Testing Intervention Components for the Smoker Who is Unwilling to Quit (PHASE4)
- The Long-Term Quitting (Smoking Cessation) Study (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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