Insulin receptor — Drug Target

All drugs that target Insulin receptor — marketed and clinical-stage. Includes 54 drug classes acting on this target.

Drug classes

Insulin Analog [EPC] · Long-acting basal insulin · Insulin (short-acting) · Insulin analog (biphasic) · Rapid-acting insulin analog · Basal insulin analog · Premixed insulin · Insulin analog mixture · insulin · Insulin, biphasic/fixed-ratio combination · Long-acting basal insulin analog · Insulin

Marketed (139)

• Lantus · Sanofi · Insulin Analog [EPC] · Metabolic
  Lantus works by mimicking the action of natural insulin to lower blood sugar levels.
• Tresiba · Novo Nordisk · Insulin Analog [EPC] · Metabolic
  Tresiba works by binding to the insulin receptor, mimicking the action of natural insulin to lower blood sugar levels.
• Novolog · Novo Nordisk · Insulin Analog [EPC] · Metabolic
  Novolog works by binding to the insulin receptor, triggering a cascade of cellular responses that lower blood glucose levels.
• Humalog · Eli Lilly · Insulin Analog [EPC] · Metabolic
  Humalog works by mimicking the natural hormone insulin to help cells absorb glucose from the bloodstream.
• Insulin Glargine 100 UNT/ML · University Hospital Tuebingen · Long-acting basal insulin · Diabetes
  Insulin glargine is a long-acting basal insulin that binds to insulin receptors on cells to promote glucose uptake and reduce blood glucose levels.
• Lantus · Rijnstate Hospital · Metabolic
• Apidra · Kinderkrankenhaus auf der Bult · Metabolic
• Insulin, regular - act rapid · HaEmek Medical Center, Israel · Insulin (short-acting) · Diabetes
  Regular insulin binds to insulin receptors on cells to promote glucose uptake and utilization, lowering blood glucose levels.
• Insulin glargine, 300U/mL · Sanofi · Long-acting basal insulin · Diabetes
  Insulin glargine is a long-acting basal insulin that binds to insulin receptors on cells to promote glucose uptake and reduce blood glucose levels.
• Insulin Aspart 70 · Medical University of Graz · Insulin analog (biphasic) · Diabetes
  Insulin Aspart 70 is a rapid-acting insulin analog that binds to insulin receptors on muscle and fat cells to facilitate glucose uptake and lower blood glucose levels.
• Insulin lispro A · Eli Lilly and Company · Rapid-acting insulin analog · Diabetes
  Insulin lispro is a rapid-acting insulin analog that binds to insulin receptors on cells to promote glucose uptake and utilization for blood sugar control.
• Insulin Lispro Protamine Suspension · Eli Lilly and Company · Basal insulin analog · Diabetes
  Insulin lispro protamine suspension is a long-acting basal insulin that binds to insulin receptors on muscle and fat cells to promote glucose uptake and storage, lowering blood glucose levels.
• insulin lispro LM · Eli Lilly and Company · Premixed insulin · Diabetes
  Insulin lispro LM is a premixed insulin formulation that combines rapid-acting insulin lispro with intermediate-acting insulin to provide both mealtime and basal glucose control.
• Insulin Lispro low mixture · Eli Lilly and Company · Rapid-acting insulin analog · Diabetes
  Insulin lispro is a rapid-acting insulin analog that binds to insulin receptors on muscle and fat cells to promote glucose uptake and lower blood glucose levels.
• Insulin Analog Mid Mixture · Eli Lilly and Company · Insulin analog mixture · Diabetes
  This insulin analog mixture mimics natural insulin by binding to insulin receptors to promote glucose uptake and utilization in cells.
• Fiasp® · Novo Nordisk A/S · Rapid-acting insulin analog · Diabetes
  Fiasp is a rapid-acting insulin analog that binds to the insulin receptor to facilitate glucose uptake and utilization in peripheral tissues.
• Step 1 · Green Cross Corporation · insulin · Diabetes
  Step 1 is a recombinant human insulin used to lower blood glucose levels in people with diabetes.
• Human insulin 30/70 · Eli Lilly and Company · Insulin, biphasic/fixed-ratio combination · Diabetes
  Human insulin 30/70 is a fixed-ratio combination of 30% short-acting insulin and 70% intermediate-acting insulin that replaces endogenous insulin to regulate blood glucose by promoting cellular glucose uptake and storage.
• Early Glargine · The Cleveland Clinic · Long-acting basal insulin analog · Diabetes
  Early Glargine is a long-acting basal insulin analog that binds to the insulin receptor to lower blood glucose by promoting glucose uptake and storage in peripheral tissues.
• Triple-daily Insulin · Hospital Universitario Dr. Jose E. Gonzalez · Insulin · Diabetes
  Triple-daily insulin replaces or supplements the body's own insulin production to regulate blood glucose levels by facilitating glucose uptake into cells and promoting glycogen synthesis.
• Inhaled insulin (Exubera) · Pfizer · Rapid-acting insulin · Diabetes
  Inhaled insulin is a rapid-acting insulin that is absorbed through the lungs to lower blood glucose by promoting glucose uptake and storage in peripheral tissues.
• INSULIN GLARGINE HOE 901 · Sanofi · Long-acting basal insulin · Diabetes
  Insulin glargine is a long-acting basal insulin that binds to insulin receptors on cells to promote glucose uptake and lower blood glucose levels.
• Lispro mix 75/25 · Eli Lilly and Company · Insulin combination product · Diabetes
  Lispro mix 75/25 is a combination insulin that provides rapid-acting insulin coverage for mealtime glucose spikes plus intermediate-acting basal insulin for baseline glucose control.
• Lispro Mixture Therapy · Eli Lilly and Company · Insulin combination therapy · Diabetes
  Lispro Mixture is a combination of rapid-acting insulin lispro and intermediate-acting insulin lispro protamine suspension that mimics physiologic insulin secretion by providing both mealtime and basal insulin coverage.
• Actrapid (human insulin) · University of Aarhus · Insulin, rapid-acting · Diabetes
  Actrapid is human insulin that binds to insulin receptors on cells to promote glucose uptake and utilization, lowering blood glucose levels.
• Levemir · Novo Nordisk · Insulin Analog [EPC] · Metabolic
  Levemir works by binding to the insulin receptor, triggering a response that lowers blood sugar levels.
• CSII(insulin Lispro) · The First Affiliated Hospital of Xiamen University · Rapid-acting insulin analog · Diabetes
  Insulin lispro is a rapid-acting insulin analog that binds to insulin receptors to facilitate glucose uptake and utilization in peripheral tissues.
• NPH/Reg · Tehran University of Medical Sciences · Insulin combination therapy · Diabetes
  NPH/Reg is a combination insulin therapy that provides both intermediate-acting (NPH) and rapid-acting (Regular) insulin to control blood glucose levels.
• premix insulin · Shanghai 6th People's Hospital · Insulin combination product · Diabetes
  Premix insulin is a combination of rapid-acting and intermediate-acting insulin that replaces or supplements the body's natural insulin to regulate blood glucose levels.
• Premixed insulin · Peking University People's Hospital · Insulin combination therapy · Diabetes
  Premixed insulin combines rapid-acting and intermediate-acting insulin to provide both immediate and sustained blood glucose control.
• Switching to NPH insulin · Providence Health & Services · Intermediate-acting insulin · Diabetes
  NPH insulin is a long-acting basal insulin that binds to insulin receptors on cells to promote glucose uptake and utilization, lowering blood glucose levels.
• Injectable insulin · Eli Lilly and Company · Insulin · Diabetes
  Injectable insulin replaces or supplements the body's own insulin to regulate blood glucose by facilitating cellular glucose uptake and storage.
• Insulin Actrapid · University of Nottingham · Rapid-acting insulin · Diabetes
  Insulin Actrapid is a rapid-acting insulin that binds to insulin receptors on cells to promote glucose uptake and utilization, lowering blood glucose levels.
• insulin glargine [rDNA origin] injection · Sanofi · Long-acting basal insulin · Diabetes
  Insulin glargine is a long-acting basal insulin that binds to insulin receptors on cells to promote glucose uptake and utilization, lowering blood glucose levels.
• NPL insulin · University of Campania Luigi Vanvitelli · Insulin analog · Diabetes
  NPL insulin is a long-acting basal insulin analog that binds to the insulin receptor to regulate blood glucose by promoting glucose uptake and storage in peripheral tissues.
• Insulin Lispro Mix50 · Eli Lilly and Company · Insulin analog, rapid-acting (premixed formulation) · Diabetes
  Insulin Lispro Mix50 is a rapid-acting insulin analog that binds to insulin receptors to facilitate glucose uptake and utilization in peripheral tissues while suppressing hepatic glucose production.
• Lispro-insulin · University of Roma La Sapienza · Rapid-acting insulin analog · Diabetes
  Lispro-insulin is a rapid-acting insulin analog that binds to insulin receptors to promote glucose uptake and utilization in peripheral tissues.
• Long acting insulin · Ain Shams University · Long-acting insulin · Diabetes
  Long-acting insulin provides sustained glucose control by mimicking the body's basal insulin secretion over an extended period.
• Twice-daily Insulin · Hospital Universitario Dr. Jose E. Gonzalez · Insulin · Diabetes
  Insulin replaces or supplements the body's own insulin to regulate blood glucose by facilitating glucose uptake into cells and promoting glycogen synthesis.
• Human Regular U-500 Insulin · Eli Lilly and Company · Insulin (short-acting/regular) · Diabetes
  Human Regular U-500 Insulin is a concentrated insulin formulation that binds to insulin receptors on cells to promote glucose uptake and utilization, lowering blood glucose levels.

Phase 3 pipeline (61)

• Humulin Insulin Mixtard · Ain Shams University · Insulin combination (rapid-acting + intermediate-acting) · Diabetes
  Humulin Insulin Mixtard is a fixed combination of rapid-acting and intermediate-acting insulin that replaces or supplements endogenous insulin to regulate blood glucose levels.
• Human Insulin Mix 50:50 · Eli Lilly and Company · Insulin preparation · Diabetes
  Human Insulin Mix 50:50 replaces deficient endogenous insulin by binding to insulin receptors on target cells to promote glucose uptake and utilization.
• Insulin Glargine Rescue Medication · Merck Sharp & Dohme LLC · Long-acting basal insulin · Diabetes
  Insulin glargine is a long-acting basal insulin that binds to insulin receptors to lower blood glucose by promoting glucose uptake and storage in peripheral tissues while suppressing hepatic glucose production.
• Gan & Lee Insulin Glargine Injection · Gan and Lee Pharmaceuticals, USA · Long-acting basal insulin · Diabetes
  Insulin glargine is a long-acting basal insulin that binds to insulin receptors to lower blood glucose by promoting glucose uptake and storage in peripheral tissues and suppressing hepatic glucose production.
• Basal Insulin and Bolus Insulin · Rabin Medical Center · Insulin therapy (basal-bolus regimen) · Diabetes
  Basal-bolus insulin therapy mimics physiological insulin secretion by combining long-acting basal insulin for fasting glucose control with rapid-acting bolus insulin for postprandial glucose management.
• Humulin L · Sanofi · Long-acting insulin · Diabetes
  Humulin L is a long-acting insulin that binds to insulin receptors to facilitate glucose uptake and utilization in peripheral tissues.
• LY2963016 · Eli Lilly and Company · Basal insulin analog · Diabetes
  LY2963016 is a long-acting basal insulin analog that binds to the insulin receptor to regulate blood glucose by promoting glucose uptake and storage.
• Intermittent insulin therapy · Mount Sinai Hospital, Canada · Insulin therapy (intermittent dosing regimen) · Diabetes
  Intermittent insulin therapy delivers insulin in periodic cycles rather than continuous infusion to improve glycemic control while potentially reducing hypoglycemia risk and insulin resistance.
• Intranasal insulin · University Health Network, Toronto · Insulin preparation · Diabetes
  Intranasal insulin delivers insulin directly to the nasal mucosa for systemic absorption, bypassing first-pass hepatic metabolism to improve glycemic control.
• Basal insulin only · Mount Sinai Hospital, Canada · Insulin (basal/long-acting) · Diabetes
  Basal insulin provides a steady, long-acting background level of insulin to regulate fasting blood glucose and suppress hepatic glucose production.
• Mylan's insulin glargine · Mylan Inc. · Insulin analog · Diabetes
  Insulin glargine is a long-acting insulin analog that mimics the action of human insulin to lower blood glucose levels.
• insulin glulisin / insulin detemir · Sanofi · insulin analog · Diabetes
  Insulin glulisine and insulin detemir work together to lower blood sugar levels by stimulating the uptake of glucose by cells.
• Faster aspart · Novo Nordisk A/S · Rapid-acting insulin analog · Diabetes
  Faster aspart is a rapid-acting insulin analog that binds to the insulin receptor to facilitate glucose uptake and utilization in peripheral tissues.
• Insulin Rinsulin® NPH · Geropharm · Intermediate-acting insulin · Diabetes
  Insulin NPH is a long-acting basal insulin that binds to insulin receptors on cells to promote glucose uptake and utilization, lowering blood glucose levels.
• Faster-acting insulin aspart · Novo Nordisk A/S · Rapid-acting insulin analog · Diabetes
  Faster-acting insulin aspart is a rapid-acting insulin analog that binds to insulin receptors to facilitate glucose uptake and utilization in peripheral tissues.
• Ultra-Rapid Lispro · Eli Lilly and Company · rapid-acting insulin analog · Diabetes
  Ultra-Rapid Lispro is a rapid-acting insulin analog that works by stimulating insulin release from the pancreas.
• glulisine insulin, glargine insulin · Population Health Research Institute · insulin analog · Diabetes
  Glulisine insulin and glargine insulin are long-acting insulin analogs that mimic the action of human insulin, stimulating glucose uptake in cells and lowering blood glucose levels.
• LY900014 · Eli Lilly and Company · Rapid-acting insulin analog · Diabetes
  LY900014 is a rapid-acting insulin lispro formulation that mimics endogenous insulin by binding to insulin receptors to facilitate glucose uptake and metabolism.
• Insulin Asparte · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · Rapid-acting insulin analog · Diabetes
  Insulin aspart is a rapid-acting insulin analog that binds to insulin receptors on cells to promote glucose uptake and utilization.
• Lantus (insulin glargine) · Sanofi · Long-acting basal insulin · Diabetes
  Lantus is a long-acting basal insulin that binds to insulin receptors to lower blood glucose by promoting glucose uptake into cells and inhibiting hepatic glucose production.
• Insulin lispro mix 25 · Eli Lilly and Company · Insulin analog, premixed formulation · Diabetes
  Insulin lispro mix 25 is a rapid-acting insulin analog combined with intermediate-acting insulin that binds to insulin receptors to facilitate glucose uptake and utilization in cells.
• LY2605541 · Eli Lilly and Company · Basal insulin analog · Diabetes
  LY2605541 is a long-acting basal insulin analog that binds to the insulin receptor to lower blood glucose levels in diabetes.
• Insulin glulisine QD · Sanofi · Rapid-acting insulin analog · Diabetes
  Insulin glulisine is a rapid-acting insulin analog that binds to insulin receptors on muscle and fat cells to facilitate glucose uptake and lower blood glucose levels.
• FlexPen NovoLog® · Mylan Inc. · Rapid-acting insulin analog · Diabetes
  NovoLog is a rapid-acting insulin analog that binds to insulin receptors to facilitate glucose uptake and utilization in cells.
• daily intranasal administration of insulin · University of Turku · Insulin · Diabetes
  Insulin is administered intranasally to lower blood glucose levels.
• Insulin Lispro Biphasic 25 · Geropharm · Premixed insulin (rapid-acting + intermediate-acting) · Diabetes
  Insulin Lispro Biphasic 25 is a premixed insulin formulation that rapidly lowers blood glucose by facilitating cellular glucose uptake and storage.
• Faster-acting Aspart insulin Fiasp · Rigshospitalet, Denmark · Rapid-acting insulin analog · Diabetes
  Fiasp is a rapid-acting insulin analog that binds to the insulin receptor to facilitate glucose uptake and utilization in peripheral tissues.
• Human Insulin Inhalation Powder · Eli Lilly and Company · Insulin (rapid-acting inhalation formulation) · Diabetes
  Human insulin delivered via inhalation powder replaces or supplements endogenous insulin to regulate blood glucose by promoting glucose uptake and utilization in peripheral tissues.
• Insulin lispro 2 day reservoir in-use · Eli Lilly and Company · Rapid-acting insulin analog · Diabetes
  Insulin lispro is a rapid-acting insulin analog that binds to insulin receptors to facilitate glucose uptake and utilization in peripheral tissues.
• Insulin aspart 6 day reservoir in-use · Eli Lilly and Company · Rapid-acting insulin analog · Diabetes
  Insulin aspart is a rapid-acting insulin analog that binds to insulin receptors to facilitate glucose uptake and utilization in peripheral tissues.
• Insulin aspart SAR341402 · Sanofi · Rapid-acting insulin analog · Diabetes
  Insulin aspart SAR341402 is a rapid-acting insulin analog that binds to the insulin receptor to facilitate glucose uptake and utilization in peripheral tissues.
• Lantus (glargine) · Massachusetts General Hospital · Long-acting basal insulin · Diabetes
  Lantus is a long-acting basal insulin that binds to insulin receptors to lower blood glucose by promoting glucose uptake and storage in cells.
• Once-daily insulin detemir · Sydney Children's Hospitals Network · Long-acting basal insulin analog · Diabetes
  Insulin detemir is a long-acting basal insulin that binds to the insulin receptor to lower blood glucose by promoting glucose uptake and storage in peripheral tissues while suppressing hepatic glucose production.
• Insulin human/Novolin® 30R · Sanofi · Insulin (human recombinant) · Diabetes
  Insulin human binds to insulin receptors on cells to promote glucose uptake and utilization, lowering blood glucose levels.
• Insulin Lispro 6 Day (6D) · Eli Lilly and Company · Rapid-acting insulin analog · Diabetes
  Insulin Lispro 6 Day is a rapid-acting insulin analog that binds to insulin receptors to facilitate glucose uptake and utilization in peripheral tissues.
• Usual insulin treatment · Centre Hospitalier Universitaire Dijon · insulin · Diabetes
  Insulin works by stimulating glucose uptake in cells, thereby lowering blood glucose levels.
• biphasic insulin aspart 70 · Novo Nordisk A/S · insulin · Diabetes
  Biphasic insulin aspart 70 works by mimicking the body's natural insulin production to regulate blood sugar levels.
• Parenteral Insulin · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · Insulin · Diabetes
  Parenteral insulin replaces or supplements the body's own insulin to regulate blood glucose by promoting glucose uptake into cells and storage as glycogen.
• Humalog Mix 50 · Eli Lilly and Company · Insulin combination therapy · Diabetes
  Humalog Mix 50 is a combination insulin therapy that provides both rapid-acting and intermediate-acting insulin to control blood glucose levels in diabetes.
• Insulin VIAject™ (90%) · Biodel · Rapid-acting insulin · Diabetes
  Insulin VIAject is a rapid-acting insulin formulation designed to achieve faster absorption and onset of action compared to standard insulin injections.