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Intermittent insulin therapy
Intermittent insulin therapy delivers insulin in periodic cycles rather than continuous infusion to improve glycemic control while potentially reducing hypoglycemia risk and insulin resistance.
Intermittent insulin therapy delivers insulin in periodic cycles rather than continuous infusion to improve glycemic control while potentially reducing hypoglycemia risk and insulin resistance. Used for Type 2 diabetes mellitus.
At a glance
| Generic name | Intermittent insulin therapy |
|---|---|
| Also known as | Basal insulin glargine and pre-meal insulin lispro |
| Sponsor | Mount Sinai Hospital, Canada |
| Drug class | Insulin therapy (intermittent dosing regimen) |
| Target | Insulin receptor |
| Modality | Small molecule |
| Therapeutic area | Diabetes |
| Phase | Phase 3 |
Mechanism of action
This approach alternates periods of insulin administration with insulin-free intervals, theoretically allowing pancreatic beta cells to recover function and reducing the development of insulin resistance. The intermittent dosing pattern may also lower the overall insulin requirement while maintaining adequate blood glucose control in diabetic patients.
Approved indications
- Type 2 diabetes mellitus
Common side effects
- Hypoglycemia
- Hyperglycemia
- Injection site reactions
- Weight gain
Key clinical trials
- Time-Restricted Eating in Combination With a Low Glycaemic Index Diet on Cognitive Function, Biological Ageing and Metabolic Health in Perimenopause and Menopause. (NA)
- Intermittent Versus Continuous Glucose Monitoring in Intensive Care Unit (NA)
- Recovery After Dialysis-Requiring Acute Kidney Injury (NA)
- Intermittent Fasting Diet Versus Resistive Exercise Program on Insulin Resistance in Obese Women With P.C.O.S (NA)
- Intermittent Fasting (IF) Has Gained Recognition as a Promising Weight Loss Approach That Improves Body Weight, Insulin Resistance, and Metabolism. While Standard Diets Are Common in PCOS Management, IF May Address the Underlying Causes of Weight Gain and Offer Additional Metabolic Benefits (NA)
- Digital Diabetes Prevention Program Study (NA)
- Intermittent Fasting Versus Carbohydrate Drinks Before Surgery (NA)
- Impacts of Intermittent Fasting on Energy Balance and Associated Health Outcomes (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |