Last reviewed 2026-04-23 · How we verify

Step 1

Step 1 is a recombinant human insulin used to lower blood glucose levels in people with diabetes.

Step 1 is a recombinant human insulin used to lower blood glucose levels in people with diabetes. Used for Diabetes mellitus, type 1, Diabetes mellitus, type 2.

At a glance

Mechanism of action

It works by stimulating glucose uptake in the muscles and suppressing glucose production in the liver. Step 1 is administered via subcutaneous injection and has a rapid onset of action.

Approved indications

• Diabetes mellitus, type 1
• Diabetes mellitus, type 2

Common side effects

• Hypoglycemia
• Weight gain
• Allergic reactions

Key clinical trials

• Living With Multimorbidity: Care Coordination and Symptom Management Program (COORDINATE) (NA)
• Testing Copanlisib as a Potential Targeted Treatment in Cancers With PIK3CA Mutations (MATCH-Subprotocol Z1F) (PHASE2)
• Effects of Changes in Driving Pressure on Intraoperative Pulmonary Dynamic Compliance and PaO₂/FiO₂ Ratio in Laparoscopic Sleeve Gastrectomy (NA)
• Influence of Tamponade on Retinal Shift in Eyes Undergoing Vitrectomy for Rhegmatogenous Retinal Detachment: A Comparison of Gas Versus Silicone Oil in a Pakistani Population (NA)
• Implementation Science to Enhance HIV Testing Services During Emergency Care in Kenya (NA)
• Thumb Base Osteoarthritis: Ultrasound-guided Platelet-rich Plasma Versus Placebo Injection (PHASE2)
• Effects of Dual Task-Oriented Circuit Training on Walking Recovery in Sub-acute Stroke (NA)
• Response-Based Dose Reduction of Linvoseltamab in the Treatment of Relapsed, Refractory, or Triple-Class Relapsed/Refractory Multiple Myeloma (PHASE1, PHASE2)

Primary sources

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