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Basal Insulin and Bolus Insulin
Basal Insulin and Bolus Insulin is a Insulin therapy (basal-bolus regimen) Small molecule drug developed by Rabin Medical Center. It is currently in Phase 3 development for Type 1 diabetes mellitus, Type 2 diabetes mellitus requiring intensive insulin therapy. Also known as: glargine, glulisine, Basal insulin glargine, Pre-meal insulin lispro.
Basal-bolus insulin therapy mimics physiological insulin secretion by combining long-acting basal insulin for fasting glucose control with rapid-acting bolus insulin for postprandial glucose management.
Basal-bolus insulin therapy mimics physiological insulin secretion by combining long-acting basal insulin for fasting glucose control with rapid-acting bolus insulin for postprandial glucose management. Used for Type 1 diabetes mellitus, Type 2 diabetes mellitus requiring intensive insulin therapy.
At a glance
| Generic name | Basal Insulin and Bolus Insulin |
|---|---|
| Also known as | glargine, glulisine, Basal insulin glargine, Pre-meal insulin lispro |
| Sponsor | Rabin Medical Center |
| Drug class | Insulin therapy (basal-bolus regimen) |
| Target | Insulin receptor |
| Modality | Small molecule |
| Therapeutic area | Diabetes |
| Phase | Phase 3 |
Mechanism of action
Basal insulin provides steady background insulin levels to suppress hepatic glucose production and maintain fasting blood glucose, while bolus insulin is administered at mealtimes to counteract postprandial glucose excursions. Together, this regimen approximates the body's natural biphasic insulin secretion pattern, improving overall glycemic control in insulin-dependent diabetes.
Approved indications
- Type 1 diabetes mellitus
- Type 2 diabetes mellitus requiring intensive insulin therapy
Common side effects
- Hypoglycemia
- Weight gain
- Injection site reactions
- Lipodystrophy
Key clinical trials
- Efficacy and Safety of Empagliflozin or Semaglutide in Overweight/Obese Patients With Type 1 Diabetes (PHASE2)
- Oral Anti Diabetic Agents in the Hospital (PHASE4)
- Relapse Among Diabetic Ketoacidosis Patients Maintained Basal Bolus Insulin Administration in Combination With Continuous Intravenous Insulin Infusion VS Non Maintaining Basal Insulin Patients (NA)
- A Randomized Trial Evaluating Control-IQ+ Technology in Adults With Type 2 Diabetes (NA)
- SHOrt-term Glycemic Control for Reducing Post-SURGical Complications (NA)
- App-Based Certified Diabetes Education Therapy (AB-CDE) (NA)
- Effect of Weekly GLP1 Agonist Treatment in "Double Diabetes" (PHASE3)
- A Research Study to Compare Two Types of Insulin, a New Weekly Insulin, Insulin Icodec and an Available Daily Insulin, Insulin Glargine, Both in Combination With Mealtime Insulin, in People With Type 2 Diabetes Who Use Daily Insulin and Mealtime Insulin (ONWARDS 4) (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Basal Insulin and Bolus Insulin CI brief — competitive landscape report
- Basal Insulin and Bolus Insulin updates RSS · CI watch RSS
- Rabin Medical Center portfolio CI
Frequently asked questions about Basal Insulin and Bolus Insulin
What is Basal Insulin and Bolus Insulin?
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Related
- Drug class: All Insulin therapy (basal-bolus regimen) drugs
- Target: All drugs targeting Insulin receptor
- Manufacturer: Rabin Medical Center — full pipeline
- Therapeutic area: All drugs in Diabetes
- Indication: Drugs for Type 1 diabetes mellitus
- Indication: Drugs for Type 2 diabetes mellitus requiring intensive insulin therapy
- Also known as: glargine, glulisine, Basal insulin glargine, Pre-meal insulin lispro
- Compare: Basal Insulin and Bolus Insulin vs similar drugs
- Pricing: Basal Insulin and Bolus Insulin cost, discount & access