Alpha-2 adrenergic receptor — Drug Target
All drugs that target Alpha-2 adrenergic receptor — marketed and clinical-stage. Includes 6 drug classes acting on this target.
Drug classes
Alpha-2 adrenergic receptor agonist · Alpha-2 adrenergic agonist · Central alpha-2 adrenergic agonist · Central-acting alpha-2 adrenergic agonist · alpha-2 adrenergic agonist · Sedative-hypnotic
Marketed (41)
- Dexmedetomidine 0.5μg／kg · Eye & ENT Hospital of Fudan University · Alpha-2 adrenergic receptor agonist · Anesthesia and Sedation
Dexmedetomidine is a selective alpha-2 adrenergic receptor agonist that produces sedation, analgesia, and anxiolysis by activating presynaptic and postsynaptic alpha-2 receptors in the central nervous system. - brimonidine 0.1% (Alphagan® P) · Allergan · Alpha-2 adrenergic receptor agonist · Ophthalmology
Brimonidine is an alpha-2 adrenergic receptor agonist that reduces intraocular pressure by decreasing aqueous humor production and increasing uveoscleral outflow in the eye. - Dexmedetomidine for sedation · Southeast University, China · Alpha-2 adrenergic receptor agonist · Anesthesia and Sedation
Dexmedetomidine is a selective alpha-2 adrenergic receptor agonist that produces sedation and analgesia by activating presynaptic and postsynaptic alpha-2 receptors in the central nervous system. - Brimonidine ophthalmic solution 0.1% · Allergan · Alpha-2 adrenergic receptor agonist · Ophthalmology
Brimonidine is an alpha-2 adrenergic receptor agonist that reduces intraocular pressure by decreasing aqueous humor production and increasing uveoscleral outflow. - Brimonidine 0.33% · Derm Research, PLLC · Alpha-2 adrenergic agonist · Dermatology
Brimonidine is an alpha-2 adrenergic agonist that constricts blood vessels and reduces erythema (redness) in the skin. - Precedex (Dexmedetomidine) · Icahn School of Medicine at Mount Sinai · Alpha-2 adrenergic receptor agonist · Anesthesia/Sedation
Dexmedetomidine is a selective alpha-2 adrenergic receptor agonist that produces sedation, analgesia, and anxiolysis by activating presynaptic and postsynaptic alpha-2 receptors in the central nervous system. - dexmedetomidine 80 µg · Fayoum University Hospital · Alpha-2 adrenergic receptor agonist · Anesthesia and Sedation
Dexmedetomidine is a selective alpha-2 adrenergic receptor agonist that produces sedation, analgesia, and anxiolysis by activating presynaptic and postsynaptic alpha-2 receptors in the central nervous system. - Oxymetazoline gel · RDD Pharma Ltd · Alpha-2 adrenergic agonist · Dermatology / Otolaryngology
Oxymetazoline is a selective alpha-2 adrenergic receptor agonist that causes vasoconstriction of blood vessels in the nasal mucosa and skin. - Dexmedetomidine 1 · National Cancer Institute, Egypt · Alpha-2 adrenergic receptor agonist · Anesthesia/Sedation
Dexmedetomidine is a selective alpha-2 adrenergic receptor agonist that produces sedation, analgesia, and anxiolysis by activating presynaptic and postsynaptic alpha-2 receptors in the central nervous system. - Dexmedetomidine load · University of Pennsylvania · Alpha-2 adrenergic agonist · Anesthesia/Sedation
Dexmedetomidine is a selective alpha-2 adrenergic agonist that produces sedation, analgesia, and anxiolysis by activating alpha-2 receptors in the central nervous system. - Brimonidine purite 0.15% · Northwestern Ophthalmic Institute S.C. · Alpha-2 adrenergic agonist · Ophthalmology
Brimonidine is an alpha-2 adrenergic agonist that reduces intraocular pressure by decreasing aqueous humor production and increasing uveoscleral outflow. - High-dose dexmedetomidine · Tang-Du Hospital · Alpha-2 adrenergic receptor agonist · Critical Care / Anesthesia
High-dose dexmedetomidine is a selective alpha-2 adrenergic receptor agonist that produces sedation, analgesia, and anxiolysis by activating presynaptic and postsynaptic alpha-2 receptors in the central nervous system. - Dexmedetomidine 0.75 microgram/kg · Sindh Institute of Urology and Transplantation · Alpha-2 adrenergic receptor agonist · Anesthesia and Sedation
Dexmedetomidine is a selective alpha-2 adrenergic receptor agonist that produces sedation, analgesia, and anxiolysis by activating presynaptic and postsynaptic alpha-2 receptors in the central nervous system. - Catapresan TTS 2 · Heart Care Foundation · Central alpha-2 adrenergic agonist · Cardiovascular
Clonidine reduces blood pressure by stimulating alpha-2 adrenergic receptors in the brain, decreasing sympathetic nervous system activity. - Intravenous dexmedetomidine · University of Jordan · Alpha-2 adrenergic receptor agonist · Anesthesia and Critical Care
Dexmedetomidine is a selective alpha-2 adrenergic receptor agonist that produces sedation, analgesia, and anxiolysis by activating presynaptic and postsynaptic alpha-2 receptors in the central nervous system. - Dexmedetomidine Hydrochloride - Cycling · Vanderbilt University Medical Center · Alpha-2 adrenergic agonist · Anesthesia/Critical Care
Dexmedetomidine hydrochloride is a selective alpha-2 adrenergic agonist that produces sedation and analgesia by activating alpha-2 receptors in the central nervous system. - Preemptive Analgesia Of Dexmedetomidine · China International Neuroscience Institution · Alpha-2 adrenergic agonist · Anesthesia and Pain Management
Dexmedetomidine is a selective alpha-2 adrenergic agonist that reduces pain perception and provides analgesia through central nervous system effects. - transdermal clonidine · Peking University People's Hospital · Alpha-2 adrenergic agonist · Cardiovascular
Transdermal clonidine is an alpha-2 adrenergic agonist that reduces sympathetic nervous system activity, lowering blood pressure and heart rate. - dexmedetomidine (IN) · Azienda Ospedaliera di Padova · Alpha-2 adrenergic receptor agonist · Anesthesia and Critical Care
Dexmedetomidine is a selective alpha-2 adrenergic receptor agonist that produces sedation, analgesia, and anxiolysis by activating presynaptic and postsynaptic alpha-2 receptors in the central nervous system. - dexmedetomidine 1 µg/kg IV · American University of Beirut Medical Center · Alpha-2 adrenergic agonist · Anesthesia/Sedation
Dexmedetomidine is a selective alpha-2 adrenergic agonist that produces sedation, analgesia, and anxiolysis by activating alpha-2 receptors in the central nervous system. - brimonidine topical gel 0.33% & SOC · Wake Forest University Health Sciences · Alpha-2 adrenergic agonist · Dermatology
Brimonidine is an alpha-2 adrenergic agonist that constricts blood vessels and reduces redness when applied topically to the skin. - APO-clonidine · University Health Network, Toronto · Alpha-2 adrenergic agonist · Cardiovascular
Clonidine is an alpha-2 adrenergic agonist that reduces sympathetic nervous system activity, lowering blood pressure and heart rate. - dexmedetomidine 2 · National Cancer Institute, Egypt · Alpha-2 adrenergic receptor agonist · Anesthesia/Sedation
Dexmedetomidine is a selective alpha-2 adrenergic receptor agonist that produces sedation, analgesia, and anxiolysis by activating presynaptic and postsynaptic alpha-2 receptors in the central nervous system. - Dexmetomidine intravenously · KAT General Hospital · Alpha-2 adrenergic receptor agonist · Anesthesia and Critical Care
Dexmedetomidine is a selective alpha-2 adrenergic receptor agonist that produces sedation, analgesia, and anxiolysis by activating presynaptic and postsynaptic alpha-2 receptors in the central nervous system. - Intraoperative infusion of dexmedetomidine · Nanjing First Hospital, Nanjing Medical University · Alpha-2 adrenergic agonist · Anesthesia/Perioperative Medicine
Dexmedetomidine is a selective alpha-2 adrenergic agonist that produces sedation, analgesia, and anxiolysis by activating alpha-2 receptors in the central nervous system. - alpha methyldopa · Radboud University Medical Center · Central-acting alpha-2 adrenergic agonist · Cardiovascular
Alpha methyldopa is a prodrug that is converted to alpha-methylnorepinephrine, which acts as a central-acting alpha-2 adrenergic agonist to reduce sympathetic outflow and lower blood pressure. - lofexidine HCl · USWM, LLC (dba US WorldMeds) · Alpha-2 adrenergic agonist · Addiction Medicine / Substance Use Disorder
Lofexidine is an alpha-2 adrenergic agonist that reduces noradrenergic hyperactivity in the central nervous system to alleviate opioid withdrawal symptoms. - dex · The Cleveland Clinic · Alpha-2 adrenergic receptor agonist · Anesthesiology
Dexmedetomidine is a selective alpha-2 adrenergic receptor agonist that induces sedation and reduces sympathetic nervous system activity. - perineural dexmedetomidine · Guangzhou Women and Children's Medical Center · Alpha-2 adrenergic agonist · Anesthesia/Pain Management
Perineural dexmedetomidine is an alpha-2 adrenergic agonist administered around nerves to provide prolonged local anesthesia and analgesia. - dexmedetomidine 0.25 µg/kg IV · American University of Beirut Medical Center · Alpha-2 adrenergic receptor agonist · Anesthesia and Sedation
Dexmedetomidine is a selective alpha-2 adrenergic receptor agonist that produces sedation, analgesia, and anxiolysis by activating presynaptic and postsynaptic alpha-2 receptors in the central nervous system. - clonidine (drug) intravenously · Medical University of Vienna · Alpha-2 adrenergic agonist · Cardiovascular
Clonidine is an alpha-2 adrenergic agonist that reduces sympathetic nervous system activity, lowering blood pressure and heart rate. - Dexmedetomidine 01 · Guangzhou General Hospital of Guangzhou Military Command · Alpha-2 adrenergic receptor agonist · Anesthesia and Sedation
Dexmedetomidine is a selective alpha-2 adrenergic receptor agonist that produces sedation, analgesia, and anxiolysis by activating presynaptic and postsynaptic alpha-2 receptors in the central nervous system. - Preemptive Dexmedetomidine injection · China International Neuroscience Institution · Alpha-2 adrenergic receptor agonist · Anesthesia and Perioperative Medicine
Dexmedetomidine is a selective alpha-2 adrenergic receptor agonist that produces sedation, analgesia, and anxiolysis by activating presynaptic and postsynaptic alpha-2 receptors in the central nervous system. - Low-dose Dexmedetomidine · Tang-Du Hospital · Alpha-2 adrenergic agonist · Anesthesia/Sedation
Low-dose dexmedetomidine is a selective alpha-2 adrenergic agonist that produces sedation, analgesia, and anxiolysis with minimal respiratory depression. - Intra-nasal Dexmedetomidine · University of Massachusetts, Worcester · Alpha-2 adrenergic agonist · Anesthesia/Sedation
Dexmedetomidine is a selective alpha-2 adrenergic agonist that produces sedation, analgesia, and anxiolysis by activating alpha-2 receptors in the central nervous system. - brimonidine tartrate ophthalmic solution · Allergan · Alpha-2 adrenergic receptor agonist · Ophthalmology
Brimonidine tartrate is an alpha-2 adrenergic receptor agonist that reduces intraocular pressure by decreasing aqueous humor production and increasing uveoscleral outflow. - Dexmedetomidine (DEX) · Ain Shams University · Alpha-2 adrenergic receptor agonist · Anesthesia and Critical Care
Dexmedetomidine is a selective alpha-2 adrenergic receptor agonist that produces sedation, analgesia, and anxiolysis by activating presynaptic and postsynaptic alpha-2 receptors in the central nervous system. - Dexmedetomidine 0.5 microgram/kg · Sindh Institute of Urology and Transplantation · Alpha-2 adrenergic receptor agonist · Anesthesia and Sedation
Dexmedetomidine is a selective alpha-2 adrenergic receptor agonist that produces sedation, analgesia, and anxiolysis by activating presynaptic and postsynaptic alpha-2 receptors in the central nervous system. - Clonidine Oral Liquid Product · Region Örebro County · Alpha-2 adrenergic agonist · Cardiovascular
Clonidine is an alpha-2 adrenergic agonist that reduces sympathetic nervous system activity by stimulating alpha-2 receptors in the brain and periphery. - Clonidine Pill · Weill Medical College of Cornell University · Alpha-2 adrenergic agonist · Cardiovascular
Clonidine is an alpha-2 adrenergic agonist that reduces sympathetic nervous system activity by stimulating alpha-2 receptors in the brain and periphery.
Phase 3 pipeline (12)
- Precedex Injectable Product · Children's Cancer Hospital Egypt 57357 · alpha-2 adrenergic agonist · Anesthesiology
Precedex Injectable Product is an alpha-2 adrenergic agonist that induces sedation and hypnosis. - Sublingual Dexmedetomidine · Nourhan M.Aly · Alpha-2 adrenergic agonist · Anesthesiology
Dexmedetomidine is an alpha-2 adrenergic agonist that acts as a sedative and anxiolytic. - Open Label Lofexidine HCL · USWM, LLC (dba US WorldMeds) · Alpha-2 adrenergic agonist · Addiction Medicine / Substance Use Disorder
Lofexidine is an alpha-2 adrenergic agonist that reduces noradrenergic hyperactivity associated with opioid withdrawal. - Brimonidine Tartrate 0.025% · Eye Therapies, LLC · Alpha-2 adrenergic agonist · Ophthalmology
Brimonidine tartrate is an alpha-2 adrenergic agonist that reduces intraocular pressure by decreasing aqueous humor production and increasing uveoscleral outflow. - local dexmedetomidine · The University of Hong Kong · Alpha-2 adrenergic receptor agonist · Anesthesiology
Local dexmedetomidine acts as an alpha-2 adrenergic receptor agonist to induce sedation and analgesia. - low dose clonidine HCl sustained release · Addrenex Pharmaceuticals, Inc. · Central alpha-2 adrenergic agonist · Cardiovascular
Clonidine HCl works by stimulating alpha-2 adrenergic receptors in the brain, which decreases sympathetic nervous system activity and lowers blood pressure. - Dexmedetomidine administered intranasally · First Affiliated Hospital of Chongqing Medical University · Alpha-2 adrenergic receptor agonist · Anesthesia/Sedation
Dexmedetomidine is a selective alpha-2 adrenergic receptor agonist that produces sedation, analgesia, and anxiolysis by activating presynaptic and postsynaptic alpha-2 receptors in the central nervous system. - clonidine gel 1% · Irmandade da Santa Casa de Misericordia de Sao Paulo · Alpha-2 adrenergic agonist · Cardiovascular
Clonidine is an alpha-2 adrenergic agonist that decreases sympathetic nervous system activity. - Dexmedetomidine 0.5 mic/kg · Al-Azhar University · Alpha-2 adrenergic agonist · Anesthesia and Sedation
Dexmedetomidine is a selective alpha-2 adrenergic agonist that produces sedation, analgesia, and anxiolysis by activating presynaptic and postsynaptic alpha-2 receptors in the central nervous system. - Dexmedetomidine sedation · KK Women's and Children's Hospital · Alpha-2 adrenergic agonist · Anesthesia and Sedation
Dexmedetomidine is a selective alpha-2 adrenergic agonist that produces sedation and analgesia by activating alpha-2 receptors in the central nervous system. - IV dexmedetomidine · The University of Hong Kong · Alpha-2 adrenergic receptor agonist · Anesthesia/Sedation
Dexmedetomidine is a selective alpha-2 adrenergic receptor agonist that produces sedation, analgesia, and anxiolysis by activating presynaptic and postsynaptic alpha-2 receptors in the central nervous system. - Dexmedetomidine Injectable Product · Eye & ENT Hospital of Fudan University · Alpha-2 adrenergic receptor agonist · Anesthesia and Sedation
Dexmedetomidine is a selective alpha-2 adrenergic receptor agonist that produces sedation, analgesia, and anxiolysis by activating presynaptic and postsynaptic alpha-2 receptors in the central nervous system.
Phase 2 pipeline (4)
- Dexmedetomidine, midazolam; fentanyl · Hospira, now a wholly owned subsidiary of Pfizer · Sedative-hypnotic · Oncology
Alpha-2 adrenergic receptor agonist - Dexmedetomidine Sublingual · NYU Langone Health · Alpha-2 adrenergic receptor agonist · Neurology
Alpha-2 adrenergic receptor agonist - Brimonidine Tartrate Gel · LEO Pharma · Alpha-2 adrenergic agonist · Dermatology
Brimonidine tartrate gel works by reducing the amount of norepinephrine in the body, which helps to decrease redness and swelling in the skin. - Envlomet SR Tablet · Daewoong Pharmaceutical Co. LTD. · Alpha-2 adrenergic receptor agonist · Pain management
Envlomet SR Tablet is a sustained-release formulation of a selective alpha-2 adrenergic receptor agonist.