What are Sedative-hypnotic drugs?

Sedative-hypnotic drugs are pharmacologic agents that share a common mechanism (typically targeting GABA-A receptor). 2 are currently marketed, with 2 more in clinical development.

What are the marketed Sedative-hypnotic drugs?

Marketed Sedative-hypnotic drugs include Oral chloral hydrate, propofol injectable emulsion.

Sedative-hypnotic

2 marketed 1 in Phase 3 1 in Phase 2

This page covers all Sedative-hypnotic drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting GABA-A receptor, GABA receptor, Alpha-2 adrenergic receptor.

Targets

GABA-A receptor · GABA receptor · Alpha-2 adrenergic receptor

Marketed (2)

Oral chloral hydrate · Seoul National University Hospital · Neurology / Sleep Medicine
Chloral hydrate is a sedative-hypnotic that enhances inhibitory neurotransmission in the central nervous system, primarily through potentiation of GABA receptors.
propofol injectable emulsion · Life Extension Foundation Inc. · Anesthesia
Propofol is a sedative-hypnotic agent that enhances inhibitory GABA neurotransmission in the central nervous system to produce rapid unconsciousness and sedation.

Phase 3 pipeline (1)

Propofol + analgesic drug · University Hospital, Brest · Anesthesiology
Propofol is a sedative-hypnotic agent that acts on the central nervous system to induce and maintain anesthesia, while the analgesic component provides pain relief.

Phase 2 pipeline (1)

Dexmedetomidine, midazolam; fentanyl · Hospira, now a wholly owned subsidiary of Pfizer · Oncology
Alpha-2 adrenergic receptor agonist