What are Alpha-2 adrenergic agonist drugs?

Alpha-2 adrenergic agonist drugs are pharmacologic agents that share a common mechanism (typically targeting Alpha-2 adrenergic receptor). 20 are currently marketed, with 8 more in clinical development.

What are the marketed Alpha-2 adrenergic agonist drugs?

Marketed Alpha-2 adrenergic agonist drugs include Brimonidine purite 0.15%, clonidine (drug) intravenously, Clonidine Oral Liquid Product, Dexmedetomidine Hydrochloride - Cycling, lofexidine HCl, perineural dexmedetomidine.

Alpha-2 adrenergic agonist

20 marketed 7 in Phase 3 1 in Phase 2

This page covers all Alpha-2 adrenergic agonist drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Alpha-2 adrenergic receptor, Alpha-2A adrenergic receptor, alpha-2 adrenergic receptor.

Targets

Alpha-2 adrenergic receptor · Alpha-2A adrenergic receptor · alpha-2 adrenergic receptor

Marketed (20)

Brimonidine purite 0.15% · Northwestern Ophthalmic Institute S.C. · Ophthalmology
Brimonidine is an alpha-2 adrenergic agonist that reduces intraocular pressure by decreasing aqueous humor production and increasing uveoscleral outflow.
clonidine (drug) intravenously · Medical University of Vienna · Cardiovascular
Clonidine is an alpha-2 adrenergic agonist that reduces sympathetic nervous system activity, lowering blood pressure and heart rate.
Clonidine Oral Liquid Product · Region Örebro County · Cardiovascular
Clonidine is an alpha-2 adrenergic agonist that reduces sympathetic nervous system activity by stimulating alpha-2 receptors in the brain and periphery.
Dexmedetomidine Hydrochloride - Cycling · Vanderbilt University Medical Center · Anesthesia/Critical Care
Dexmedetomidine hydrochloride is a selective alpha-2 adrenergic agonist that produces sedation and analgesia by activating alpha-2 receptors in the central nervous system.
lofexidine HCl · USWM, LLC (dba US WorldMeds) · Addiction Medicine / Substance Use Disorder
Lofexidine is an alpha-2 adrenergic agonist that reduces noradrenergic hyperactivity in the central nervous system to alleviate opioid withdrawal symptoms.
perineural dexmedetomidine · Guangzhou Women and Children's Medical Center · Anesthesia/Pain Management
Perineural dexmedetomidine is an alpha-2 adrenergic agonist administered around nerves to provide prolonged local anesthesia and analgesia.
Intra-nasal Dexmedetomidine · University of Massachusetts, Worcester · Anesthesia/Sedation
Dexmedetomidine is a selective alpha-2 adrenergic agonist that produces sedation, analgesia, and anxiolysis by activating alpha-2 receptors in the central nervous system.
Zanaflex® · Icahn School of Medicine at Mount Sinai · Neurology
Zanaflex is an alpha-2 adrenergic agonist that reduces muscle spasticity by increasing inhibitory neurotransmission in the spinal cord.
Oxymetazoline gel · RDD Pharma Ltd · Dermatology / Otolaryngology
Oxymetazoline is a selective alpha-2 adrenergic receptor agonist that causes vasoconstriction of blood vessels in the nasal mucosa and skin.
Brimonidine 0.33% · Derm Research, PLLC · Dermatology
Brimonidine is an alpha-2 adrenergic agonist that constricts blood vessels and reduces erythema (redness) in the skin.
dexmedetomidine 1 µg/kg IV · American University of Beirut Medical Center · Anesthesia/Sedation
Dexmedetomidine is a selective alpha-2 adrenergic agonist that produces sedation, analgesia, and anxiolysis by activating alpha-2 receptors in the central nervous system.
Brimonidine 0.33% gel (Br) · Galderma R&D · Dermatology
Brimonidine is an alpha-2 adrenergic agonist that constricts blood vessels and reduces redness in the skin.
Intraoperative infusion of dexmedetomidine · Nanjing First Hospital, Nanjing Medical University · Anesthesia/Perioperative Medicine
Dexmedetomidine is a selective alpha-2 adrenergic agonist that produces sedation, analgesia, and anxiolysis by activating alpha-2 receptors in the central nervous system.
Dexmedetomidine load · University of Pennsylvania · Anesthesia/Sedation
Dexmedetomidine is a selective alpha-2 adrenergic agonist that produces sedation, analgesia, and anxiolysis by activating alpha-2 receptors in the central nervous system.
Clonidine Pill · Weill Medical College of Cornell University · Cardiovascular
Clonidine is an alpha-2 adrenergic agonist that reduces sympathetic nervous system activity by stimulating alpha-2 receptors in the brain and periphery.
Preemptive Analgesia Of Dexmedetomidine · China International Neuroscience Institution · Anesthesia and Pain Management
Dexmedetomidine is a selective alpha-2 adrenergic agonist that reduces pain perception and provides analgesia through central nervous system effects.
brimonidine topical gel 0.33% & SOC · Wake Forest University Health Sciences · Dermatology
Brimonidine is an alpha-2 adrenergic agonist that constricts blood vessels and reduces redness when applied topically to the skin.
APO-clonidine · University Health Network, Toronto · Cardiovascular
Clonidine is an alpha-2 adrenergic agonist that reduces sympathetic nervous system activity, lowering blood pressure and heart rate.
Low-dose Dexmedetomidine · Tang-Du Hospital · Anesthesia/Sedation
Low-dose dexmedetomidine is a selective alpha-2 adrenergic agonist that produces sedation, analgesia, and anxiolysis with minimal respiratory depression.
transdermal clonidine · Peking University People's Hospital · Cardiovascular
Transdermal clonidine is an alpha-2 adrenergic agonist that reduces sympathetic nervous system activity, lowering blood pressure and heart rate.

Phase 3 pipeline (7)

Precedex Injectable Product · Children's Cancer Hospital Egypt 57357 · Anesthesiology
Precedex Injectable Product is an alpha-2 adrenergic agonist that induces sedation and hypnosis.
clonidine gel 1% · Irmandade da Santa Casa de Misericordia de Sao Paulo · Cardiovascular
Clonidine is an alpha-2 adrenergic agonist that decreases sympathetic nervous system activity.
Open Label Lofexidine HCL · USWM, LLC (dba US WorldMeds) · Addiction Medicine / Substance Use Disorder
Lofexidine is an alpha-2 adrenergic agonist that reduces noradrenergic hyperactivity associated with opioid withdrawal.
Brimonidine Tartrate 0.025% · Eye Therapies, LLC · Ophthalmology
Brimonidine tartrate is an alpha-2 adrenergic agonist that reduces intraocular pressure by decreasing aqueous humor production and increasing uveoscleral outflow.
Dexmedetomidine 0.5 mic/kg · Al-Azhar University · Anesthesia and Sedation
Dexmedetomidine is a selective alpha-2 adrenergic agonist that produces sedation, analgesia, and anxiolysis by activating presynaptic and postsynaptic alpha-2 receptors in the central nervous system.
Dexmedetomidine sedation · KK Women's and Children's Hospital · Anesthesia and Sedation
Dexmedetomidine is a selective alpha-2 adrenergic agonist that produces sedation and analgesia by activating alpha-2 receptors in the central nervous system.
Sublingual Dexmedetomidine · Nourhan M.Aly · Anesthesiology
Dexmedetomidine is an alpha-2 adrenergic agonist that acts as a sedative and anxiolytic.

Phase 2 pipeline (1)

Brimonidine Tartrate Gel · LEO Pharma · Dermatology
Brimonidine tartrate gel works by reducing the amount of norepinephrine in the body, which helps to decrease redness and swelling in the skin.