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Dexmedetomidine 0.5 mic/kg
Dexmedetomidine is a selective alpha-2 adrenergic agonist that produces sedation, analgesia, and anxiolysis by activating presynaptic and postsynaptic alpha-2 receptors in the central nervous system.
Dexmedetomidine is a selective alpha-2 adrenergic agonist that produces sedation, analgesia, and anxiolysis by activating presynaptic and postsynaptic alpha-2 receptors in the central nervous system. Used for Sedation in intensive care unit patients, Perioperative sedation and analgesia, Sedation during mechanical ventilation.
At a glance
| Generic name | Dexmedetomidine 0.5 mic/kg |
|---|---|
| Sponsor | Al-Azhar University |
| Drug class | Alpha-2 adrenergic agonist |
| Target | Alpha-2 adrenergic receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesia and Sedation |
| Phase | Phase 3 |
Mechanism of action
Dexmedetomidine binds with high selectivity to alpha-2 adrenergic receptors, particularly in the locus coeruleus and other brainstem regions, leading to inhibition of norepinephrine release and reduced neuronal firing. This results in a unique sedative state characterized by maintained airway reflexes and the ability to be aroused, along with analgesic and anxiolytic effects. The drug produces dose-dependent sedation without significant respiratory depression at clinical doses.
Approved indications
- Sedation in intensive care unit patients
- Perioperative sedation and analgesia
- Sedation during mechanical ventilation
Common side effects
- Hypotension
- Bradycardia
- Hypertension (transient, initial)
- Dry mouth
- Headache
- Nausea