Last reviewed 2026-04-23 · How we verify

Precedex Injectable Product

Precedex Injectable Product is an alpha-2 adrenergic agonist that induces sedation and hypnosis.

Precedex Injectable Product is an alpha-2 adrenergic agonist that induces sedation and hypnosis. Used for Sedation of intubated and mechanically ventilated patients, Sedation of patients in intensive care units.

At a glance

Mechanism of action

It works by stimulating alpha-2 adrenergic receptors in the brain, leading to a decrease in the activity of neurons and a subsequent sedative effect. This results in a decrease in the amount of neurotransmitters such as norepinephrine and serotonin, which are involved in arousal and wakefulness.

Approved indications

• Sedation of intubated and mechanically ventilated patients
• Sedation of patients in intensive care units

Common side effects

• Respiratory depression
• Hypotension
• Bradycardia

Key clinical trials

• Using Lidocaine or Dexmedetomidine to Help Control Blood Pressure Spikes From a Tourniquet During Knee Surgery (PHASE2)
• PENG Block With Dexmedetomidine in Older Adults (NA)
• Effect of Tegileridine on Postoperative Bowel Function Recovery in Abdominal Surgery (PHASE4)
• Opioid Sparing Analgesia Continuous Intraoperative Infusion of Dexmedetomidine Versus Lidocaine for Laparoscopic Cholecystectomy (PHASE4)
• Sedation Efficacy and Safety of Remazolam Besylate in Ventilated Surgical Critically Ill Patients (PHASE4)
• Effect of Intravenous or Intrathecal Dexmedetomidine on Bupivacaine Spinal Block in Lower Abdominal Surgery (PHASE2, PHASE3)
• Investigation of Sleep in the Intensive Care Unit (PHASE2)
• Dexmedetomidine and Long-term Outcomes in Elderly Patients After Cardiac Surgery (NA)

Primary sources

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