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clonidine (drug) intravenously
Clonidine is an alpha-2 adrenergic agonist that reduces sympathetic nervous system activity, lowering blood pressure and heart rate.
Clonidine is an alpha-2 adrenergic agonist that reduces sympathetic nervous system activity, lowering blood pressure and heart rate. Used for Hypertension (acute management via intravenous route), Perioperative hemodynamic control, Sedation and analgesia in intensive care settings.
At a glance
| Generic name | clonidine (drug) intravenously |
|---|---|
| Sponsor | Medical University of Vienna |
| Drug class | Alpha-2 adrenergic agonist |
| Target | Alpha-2 adrenergic receptor |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | FDA-approved |
Mechanism of action
Clonidine binds to alpha-2 adrenergic receptors in the central nervous system, decreasing the release of norepinephrine and reducing sympathetic outflow. This results in decreased peripheral vascular resistance and lower blood pressure. When administered intravenously, it provides rapid onset of action for acute hypertensive episodes and perioperative hemodynamic management.
Approved indications
- Hypertension (acute management via intravenous route)
- Perioperative hemodynamic control
- Sedation and analgesia in intensive care settings
Common side effects
- Hypotension
- Bradycardia
- Sedation
- Dry mouth
- Rebound hypertension (upon discontinuation)
Key clinical trials
- Clonidine to Prevent Delirium After Electroconvulsive Therapy. (PHASE4)
- Additive Effects of Clonidine Used in Propofol Sedation in Colonoscopy (NA)
- The PREVENT AGITATION Trial II - Children ≤1 Year (PHASE2, PHASE3)
- The Comparative Efficacy and Safety of Two General Anesthesia Protocols Consisting of Fentanyl Plus Propofol Plus Rococuronium Plus Isoflurane Versus Ketamime Plus Magnesium Sulphate Plus Lidocaine Plus Clonidine Plus Propofol Plus Rococuronium Plus Isoflurane for Gynaecology Surgery in Cameroon (NA)
- Concepts for Analgosedation During Placement of Regional Anaesthesia Before Operations. (PHASE4)
- Clonidine Versus Adenosine to Treat Neuropathic Pain (PHASE2)
- Double Blind Placebo Controlled Study of Outpatient Intravenous Ketamine for the Treatment of CRPS (PHASE2)
- Effects of Intravenous Clonidine on Ocular Blood Flow and Intraocular Pressure (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- clonidine (drug) intravenously CI brief — competitive landscape report
- clonidine (drug) intravenously updates RSS · CI watch RSS
- Medical University of Vienna portfolio CI