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Intraoperative infusion of dexmedetomidine
Intraoperative infusion of dexmedetomidine is a Alpha-2 adrenergic agonist Small molecule drug developed by Nanjing First Hospital, Nanjing Medical University. It is currently FDA-approved for Intraoperative sedation and analgesia during surgical procedures, Perioperative anxiolysis.
Dexmedetomidine is a selective alpha-2 adrenergic agonist that produces sedation, analgesia, and anxiolysis by activating alpha-2 receptors in the central nervous system.
Dexmedetomidine is a selective alpha-2 adrenergic agonist that produces sedation, analgesia, and anxiolysis by activating alpha-2 receptors in the central nervous system. Used for Intraoperative sedation and analgesia during surgical procedures, Perioperative anxiolysis.
At a glance
| Generic name | Intraoperative infusion of dexmedetomidine |
|---|---|
| Sponsor | Nanjing First Hospital, Nanjing Medical University |
| Drug class | Alpha-2 adrenergic agonist |
| Target | Alpha-2 adrenergic receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesia/Perioperative Medicine |
| Phase | FDA-approved |
Mechanism of action
Dexmedetomidine binds to alpha-2 adrenergic receptors in the locus coeruleus and other brain regions, reducing norepinephrine release and producing a unique sedative state characterized by maintained airway reflexes and responsiveness to stimulation. When used as an intraoperative infusion, it provides sedation and analgesia while preserving respiratory drive, making it useful for perioperative anxiolysis and analgesia reduction.
Approved indications
- Intraoperative sedation and analgesia during surgical procedures
- Perioperative anxiolysis
Common side effects
- Hypotension
- Bradycardia
- Hypertension (transient, initial)
- Dry mouth
- Dizziness
Key clinical trials
- Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery
- Using Lidocaine or Dexmedetomidine to Help Control Blood Pressure Spikes From a Tourniquet During Knee Surgery (PHASE2)
- Comparison of Anesthetic Techniques for Early Recovery After Ankle Arthroscopy (NA)
- Intrathecal Morphine for Recovery and Outcomes After VATS (NA)
- Tubeless Spontaneous Ventilation Anesthesia in Kidney Transplantation (NA)
- Opioid-Free vs Opioid-Based Anesthesia for Nasal Surgeries (PHASE3)
- Opioid Sparing Analgesia Continuous Intraoperative Infusion of Dexmedetomidine Versus Lidocaine for Laparoscopic Cholecystectomy (PHASE4)
- EEG-Guided Analgesic Titration During General Anesthesia to Improve Early Neurocognitive Recovery in Older Patients (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Intraoperative infusion of dexmedetomidine CI brief — competitive landscape report
- Intraoperative infusion of dexmedetomidine updates RSS · CI watch RSS
- Nanjing First Hospital, Nanjing Medical University portfolio CI
Frequently asked questions about Intraoperative infusion of dexmedetomidine
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Related
- Drug class: All Alpha-2 adrenergic agonist drugs
- Target: All drugs targeting Alpha-2 adrenergic receptor
- Manufacturer: Nanjing First Hospital, Nanjing Medical University — full pipeline
- Therapeutic area: All drugs in Anesthesia/Perioperative Medicine
- Indication: Drugs for Intraoperative sedation and analgesia during surgical procedures
- Indication: Drugs for Perioperative anxiolysis
- Compare: Intraoperative infusion of dexmedetomidine vs similar drugs
- Pricing: Intraoperative infusion of dexmedetomidine cost, discount & access