{"id":"intraoperative-infusion-of-dexmedetomidine","safety":{"commonSideEffects":[{"rate":"10-30","effect":"Hypotension"},{"rate":"5-25","effect":"Bradycardia"},{"rate":"5-15","effect":"Hypertension (transient, initial)"},{"rate":"5-10","effect":"Dry mouth"},{"rate":"5-10","effect":"Dizziness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dexmedetomidine binds to alpha-2 adrenergic receptors in the locus coeruleus and other brain regions, reducing norepinephrine release and producing a unique sedative state characterized by maintained airway reflexes and responsiveness to stimulation. When used as an intraoperative infusion, it provides sedation and analgesia while preserving respiratory drive, making it useful for perioperative anxiolysis and analgesia reduction.","oneSentence":"Dexmedetomidine is a selective alpha-2 adrenergic agonist that produces sedation, analgesia, and anxiolysis by activating alpha-2 receptors in the central nervous system.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:49:48.424Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Intraoperative sedation and analgesia during surgical procedures"},{"name":"Perioperative anxiolysis"}]},"trialDetails":[{"nctId":"NCT07489001","phase":"","title":"Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery","status":"RECRUITING","sponsor":"Marmara University","startDate":"2025-12-09","conditions":"Lumbar Spinal Stenosis, Lumbar Disc Herniation With Radiculopathy, Lumbar Degenerative 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