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Low-dose Dexmedetomidine
Low-dose dexmedetomidine is a selective alpha-2 adrenergic agonist that produces sedation, analgesia, and anxiolysis with minimal respiratory depression.
Low-dose dexmedetomidine is a selective alpha-2 adrenergic agonist that produces sedation, analgesia, and anxiolysis by activating presynaptic alpha-2 receptors in the central nervous system. Used for Sedation in intensive care unit (ICU) patients, Procedural sedation, Anxiolysis and analgesia in perioperative settings.
At a glance
| Generic name | Low-dose Dexmedetomidine |
|---|---|
| Also known as | Yisi |
| Sponsor | Tang-Du Hospital |
| Drug class | Alpha-2 adrenergic agonist |
| Target | Alpha-2 adrenergic receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesia/Sedation |
| Phase | FDA-approved |
Mechanism of action
Dexmedetomidine binds to alpha-2 adrenergic receptors in the central nervous system, particularly in the locus coeruleus, producing dose-dependent sedation and analgesia. At low doses, it provides anxiolytic and analgesic effects while preserving airway reflexes and maintaining spontaneous breathing, making it suitable for conscious sedation and perioperative use.
Approved indications
- Sedation in intensive care unit patients
- Perioperative anxiolysis and analgesia
- Conscious sedation for procedures
Common side effects
- Hypotension
- Bradycardia
- Dry mouth
- Hypertension (transient, initial)
- Rebound hypertension on discontinuation
Key clinical trials
- Awareness Neuraxial Versus General Anesthesia in Frail Patients Undergoing Laparoscopic or Robotic Abdominopelvic Surgery. (NA)
- Effect of Dexmedetomidine Dosage on Postoperative Delirium in Geriatric Orthopedic Surgery (PHASE2)
- Efficacy of Non-weight Based, Low Dose Dex-Dex Adjuncts in Prolonging Peripheral Nerve Blocks (PHASE1, PHASE2)
- Propofol-Only Versus Dexmedetomidine-Propofol in Children Undergoing Magnetic Resonance Imaging (PHASE4)
- Comparative Dose-Response of Intrathecal Dexmedetomidine for Post-Spinal Shivering (PHASE3)
- Low Dose Dexmedetomidine Versus Normal Saline in Multiple Fracture Ribs (PHASE3)
- COMPARISON OF OPIOID-FREE AND OPIOID-BASED ANESTHESIA TECHNIQUES ON qNOX INDEX IN ABDOMINAL SURGERY UNDER GENERAL ANESTHESIA (NA)
- Dexmedetomidine-Enhanced PCIA After Lobectomy in Nicotine-Dependent Patients (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |