{"id":"low-dose-dexmedetomidine","safety":{"commonSideEffects":[{"rate":"10-20","effect":"Hypotension"},{"rate":"5-15","effect":"Bradycardia"},{"rate":"5-10","effect":"Dry mouth"},{"rate":"5-10","effect":"Hypertension (transient, initial)"},{"rate":null,"effect":"Rebound hypertension on discontinuation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dexmedetomidine binds to alpha-2 adrenergic receptors in the central nervous system, particularly in the locus coeruleus, producing dose-dependent sedation and analgesia. At low doses, it provides anxiolytic and analgesic effects while preserving airway reflexes and maintaining spontaneous breathing, making it suitable for conscious sedation and perioperative use.","oneSentence":"Low-dose dexmedetomidine is a selective alpha-2 adrenergic agonist that produces sedation, analgesia, and anxiolysis with minimal respiratory depression.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:53:19.763Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Sedation in intensive care unit patients"},{"name":"Perioperative anxiolysis and analgesia"},{"name":"Conscious sedation for procedures"}]},"trialDetails":[{"nctId":"NCT07486336","phase":"NA","title":"Awareness Neuraxial Versus General Anesthesia in Frail Patients Undergoing Laparoscopic or Robotic Abdominopelvic Surgery.","status":"NOT_YET_RECRUITING","sponsor":"Ente Ospedaliero Ospedali Galliera","startDate":"2026-09-01","conditions":"Fraily, Abdominal Surgery, Postoperative Cognitive Dysfunction (POCD)","enrollment":100},{"nctId":"NCT07443085","phase":"PHASE2","title":"Effect of Dexmedetomidine Dosage on Postoperative Delirium in Geriatric Orthopedic Surgery","status":"RECRUITING","sponsor":"Benha University","startDate":"2026-02-26","conditions":"Delirium - Postoperative","enrollment":75},{"nctId":"NCT07099222","phase":"PHASE1, PHASE2","title":"Efficacy of Non-weight Based, Low Dose Dex-Dex Adjuncts in Prolonging Peripheral Nerve Blocks","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Arizona","startDate":"2024-10-10","conditions":"Postoperative Pain, Nausea and Vomiting, Postoperative, Dizziness","enrollment":100},{"nctId":"NCT07369128","phase":"PHASE4","title":"Propofol-Only Versus Dexmedetomidine-Propofol in Children Undergoing Magnetic Resonance Imaging","status":"NOT_YET_RECRUITING","sponsor":"Boston Children's Hospital","startDate":"2026-02","conditions":"MRI Sedation, Pediatric Sedation, Propofol Dosage","enrollment":105},{"nctId":"NCT07327879","phase":"PHASE3","title":"Comparative Dose-Response of Intrathecal Dexmedetomidine for Post-Spinal Shivering","status":"NOT_YET_RECRUITING","sponsor":"Al-Azhar University","startDate":"2026-01-28","conditions":"Post-Spinal Shivering","enrollment":120},{"nctId":"NCT04928300","phase":"PHASE3","title":"Low Dose Dexmedetomidine Versus Normal Saline in Multiple Fracture Ribs","status":"RECRUITING","sponsor":"Assiut University","startDate":"2021-06-12","conditions":"Rib Fractures","enrollment":60},{"nctId":"NCT07310524","phase":"NA","title":"COMPARISON OF OPIOID-FREE AND OPIOID-BASED ANESTHESIA TECHNIQUES ON qNOX INDEX IN ABDOMINAL SURGERY UNDER GENERAL ANESTHESIA","status":"COMPLETED","sponsor":"Muhammad Rahman Efendi Nasution","startDate":"2025-09-08","conditions":"Opioid-free Anesthesia","enrollment":42},{"nctId":"NCT07306702","phase":"PHASE4","title":"Dexmedetomidine-Enhanced PCIA After Lobectomy in Nicotine-Dependent Patients","status":"COMPLETED","sponsor":"Shenyang Sixth People's Hospital","startDate":"2023-07-01","conditions":"Postoperative Pain Management","enrollment":102},{"nctId":"NCT07167316","phase":"PHASE1","title":"The Role of the LC-NA System in Experimental Sleep Fragmentation","status":"NOT_YET_RECRUITING","sponsor":"Hans-Peter Landolt","startDate":"2026-01-05","conditions":"The Role of the LC-NA System in Sleep Regulation","enrollment":42},{"nctId":"NCT06067893","phase":"PHASE4","title":"Low Dose Dexmedetomidine as a Postoperative Pain Adjunct","status":"ENROLLING_BY_INVITATION","sponsor":"Nichole Doyle","startDate":"2024-07-01","conditions":"Spinal Fusion, Adolescent Idiopathic Scoliosis","enrollment":160},{"nctId":"NCT03263117","phase":"PHASE4","title":"SEdation Versus General Anesthesia for Endovascular Therapy in Acute Ischemic Stroke","status":"COMPLETED","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2018-07-01","conditions":"Stroke","enrollment":260},{"nctId":"NCT07246447","phase":"NA","title":"Ketodex Versus Opioid Based Anesthesia in Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy.","status":"NOT_YET_RECRUITING","sponsor":"Cairo University","startDate":"2025-11","conditions":"Morbid Obesity","enrollment":8},{"nctId":"NCT07077200","phase":"","title":"Comparison of Intranasal Dexmedetomidine and Short Video Viewing in the Preoperative Anxiety","status":"COMPLETED","sponsor":"Samsun University","startDate":"2025-07-01","conditions":"Anesthesia, Sedation, Anxiety","enrollment":50},{"nctId":"NCT07180810","phase":"NA","title":"Effect of Dexmedetomidine Infusion on Post Anesthesia Discharge Time","status":"COMPLETED","sponsor":"Shaukat Khanum Memorial Cancer Hospital & Research Centre","startDate":"2023-09-05","conditions":"Post Anesthesia Discharge Time in Patients of Breast Cancer Surgery","enrollment":82},{"nctId":"NCT07168720","phase":"PHASE2","title":"The Study is Being Conducted to Evaluate the Efficacy and Safety of Dexmedetomidine Hydrochloride Microneedles for Preoperative Sedation in Children","status":"RECRUITING","sponsor":"Guangzhou Novaken Pharm Co., Ltd.","startDate":"2025-08-29","conditions":"Preoperative Sedation","enrollment":64},{"nctId":"NCT07179913","phase":"PHASE4","title":"The Improvement of Low-dose Esketamine on Postoperative Depression in Patients Undergoing Bariatric Surgery With Preoperative Depression","status":"NOT_YET_RECRUITING","sponsor":"The First Hospital of Jilin University","startDate":"2025-09-10","conditions":"Depressed, Bariatric Surgery","enrollment":40},{"nctId":"NCT06685965","phase":"PHASE2","title":"A Study to Evaluate Effects on Sleep and Safety of RE03 in PTSD Patients With Sleep Disturbances","status":"RECRUITING","sponsor":"Reconnect Labs","startDate":"2025-09-10","conditions":"Posttraumatic Stress Disorder (PTSD), Sleep Disturbances and Insomnia","enrollment":24},{"nctId":"NCT07145814","phase":"NA","title":"Dexmedetomidine Dose-Dependent on Lung Function and AQP1 in One-Lung Ventilation Surgery","status":"COMPLETED","sponsor":"People's Hospital of Guangxi Zhuang Autonomous Region","startDate":"2018-01-05","conditions":"Acute Lung Injury(ALI)","enrollment":60},{"nctId":"NCT07125573","phase":"NA","title":"The Effect of Esketamine Combined With Dexmedetomidine on Postoperative Recovery Quality in Patients Undergoing Thoracoscopic Surgery","status":"ENROLLING_BY_INVITATION","sponsor":"First Affiliated Hospital of Kunming Medical University","startDate":"2025-05-01","conditions":"Esketamine Plus Dexmedetomidine Affect Postoperative Quality, Thoracoscopy, Lung Neoplasms","enrollment":120},{"nctId":"NCT07114263","phase":"NA","title":"Study of The Analgesic Profile of Two Adjuvants Added to Low Dose Hyperbaric Bupivacaine Versus One Adjuvant in Patients Undergoing Anal Surgery Using Spinal Anesthesia","status":"NOT_YET_RECRUITING","sponsor":"Tanta University","startDate":"2025-08","conditions":"Spinal Anesthesia Administration, Analgesic, Anorectal Surgery","enrollment":60},{"nctId":"NCT04876937","phase":"NA","title":"Low-Dose Dexmedetomidine for Delirium Prevention in Mechanically Ventilated Septic Patients","status":"TERMINATED","sponsor":"Peking University First Hospital","startDate":"2021-05-28","conditions":"Adult, Intensive Care Unit, Sepsis","enrollment":42},{"nctId":"NCT05246007","phase":"NA","title":"Nocturnal Low-dose Dexmedetomidine Infusion and Perioperative Sleep Quality","status":"WITHDRAWN","sponsor":"Peking University First Hospital","startDate":"2022-05","conditions":"Old Age, Knee Replacement Surgery, Hip Replacement Surgery","enrollment":""},{"nctId":"NCT03089905","phase":"PHASE3","title":"A Study to Compare the Long-term Outcomes After Two Different Anaesthetics","status":"ACTIVE_NOT_RECRUITING","sponsor":"Murdoch Childrens Research Institute","startDate":"2017-08-10","conditions":"Anesthesia, Neurotoxicity, Child Development","enrollment":450},{"nctId":"NCT04204798","phase":"NA","title":"Dexmedetomidine and Outcomes of Elderly Admitted to ICU After Surgery","status":"ACTIVE_NOT_RECRUITING","sponsor":"Peking University First Hospital","startDate":"2020-08-28","conditions":"Elderly, Surgery, Intensive Care Unit","enrollment":1410},{"nctId":"NCT03172897","phase":"PHASE4","title":"Low-dose Dexmedetomidine in Mechanically Ventilated ICU Patients","status":"SUSPENDED","sponsor":"Peking University First Hospital","startDate":"2017-08-20","conditions":"Adult Disease, Intensive Care Unit Syndrome, Mechanical Ventilation Complication","enrollment":260},{"nctId":"NCT06062550","phase":"PHASE4","title":"Different Dose Esketamine and Dexmedetomidine Combination for Supplemental Analgesia After Scoliosis Correction Surgery","status":"RECRUITING","sponsor":"Peking University First Hospital","startDate":"2023-10-24","conditions":"Scoliosis Correction, Esketamine, Dexmedetomidine","enrollment":312},{"nctId":"NCT05732064","phase":"PHASE4","title":"Dexmedetomidine-esketamine Combined Nasal Administration and Perioperative Sleep Quality","status":"COMPLETED","sponsor":"Peking University First Hospital","startDate":"2023-05-22","conditions":"Breast Cancer, Perioperative Period, Dexmedetomidine","enrollment":180},{"nctId":"NCT06087510","phase":"PHASE4","title":"Different Dose Esketamine and Dexmedetomidine for Supplemental Analgesia and Longterm Outcomes","status":"RECRUITING","sponsor":"Peking University First Hospital","startDate":"2024-01-24","conditions":"Scoliosis Correction, Postoperative Analgesia, Esketamine","enrollment":312},{"nctId":"NCT06031883","phase":"PHASE1, PHASE2","title":"Efficacy of Adding Low Dose Ketamine or Fentanyl to Propofol-dexmedetomidine as Total Intravenous Anesthesia","status":"COMPLETED","sponsor":"Minia University","startDate":"2023-02-01","conditions":"Patients Undergoing Elective Craniotomy","enrollment":40},{"nctId":"NCT04964219","phase":"PHASE4","title":"Analgesic Effects of Low-dose S-ketamine in Major Spine Fusion Surgery","status":"COMPLETED","sponsor":"Peking University First Hospital","startDate":"2022-02-08","conditions":"S-ketamine, Postoperative Analgesia, Spine Fusion","enrollment":164},{"nctId":"NCT07022821","phase":"PHASE4","title":"Comparison of Dexmedetomidine + Ketamine for Postoperative Pain in C-Section","status":"RECRUITING","sponsor":"Fatima Memorial Hospital","startDate":"2025-05-16","conditions":"Postoperative Pain, Cesarean Section Pain","enrollment":90},{"nctId":"NCT04824144","phase":"PHASE1, PHASE2","title":"Effects of Dexmedetomidine in Patients With Agitated Delirium in Palliative Care","status":"RECRUITING","sponsor":"Bruyère Health Research Institute.","startDate":"2024-01-30","conditions":"Hyperactive Delirium, Delirium of Mixed Origin","enrollment":50},{"nctId":"NCT03624595","phase":"NA","title":"Low-dose Dexmedetomidine and Postoperative Delirium After Cardiac Surgery","status":"ACTIVE_NOT_RECRUITING","sponsor":"Dong-Xin Wang","startDate":"2019-04-16","conditions":"Cardiac Surgery, Cardiopulmonary Bypass, Dexmedetomidine","enrollment":502},{"nctId":"NCT04751812","phase":"NA","title":"Venous Cannulation Pain to Guide Choice of Anesthetic Method","status":"COMPLETED","sponsor":"Region Halland","startDate":"2022-03-01","conditions":"Pain, Postoperative, Pain Prediction, Laparoscopic Surgery","enrollment":270},{"nctId":"NCT06899841","phase":"PHASE2, PHASE3","title":"Dexmedetomidine in Sonographic Guided Erector Spinae Plane Block","status":"RECRUITING","sponsor":"Assiut University","startDate":"2024-10-01","conditions":"Pain Management","enrollment":90},{"nctId":"NCT06838650","phase":"PHASE3","title":"Beneficial Effects of Low-Dose Intravenous Dexmedetomidine Premedication in Patient Undergoing Laparoscopic Cholecystectomy Under General Anesthesia","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2025-03-01","conditions":"Laparoscopic Cholecystectomy Surgery","enrollment":100},{"nctId":"NCT06830564","phase":"PHASE2, PHASE3","title":"Emergence Agitation of Sevoflurane in Pediatric","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2024-05-01","conditions":"Emergence Delirium","enrollment":126},{"nctId":"NCT05895838","phase":"PHASE3","title":"The Danish Out-of-Hospital Cardiac Arrest Study","status":"RECRUITING","sponsor":"Christian Hassager","startDate":"2023-06-16","conditions":"Out-Of-Hospital Cardiac Arrest, Post-Cardiac Arrest Syndrome","enrollment":1000},{"nctId":"NCT06771466","phase":"NA","title":"Post-c-section Pain Control Satisfaction with Erector Spinae Simple Block Vs Lateral Quadratus Lumborum Block","status":"NOT_YET_RECRUITING","sponsor":"Wael Sayed El Gharabawy","startDate":"2025-03","conditions":"Satisfaction, Pain Management After Surgery","enrollment":126},{"nctId":"NCT06738043","phase":"NA","title":"Dexmedetomidine Versus Ketamine as Adjuvants in Bariatric Surgery","status":"NOT_YET_RECRUITING","sponsor":"Tanta University","startDate":"2024-12-20","conditions":"Obesity, Postoperative Pain, Bariatric Surgery","enrollment":90},{"nctId":"NCT05249153","phase":"NA","title":"Dexmedetomidine and Sufentanil Effect in PCA on Pediatric Patients Undergoing Scoliosis Surgery","status":"UNKNOWN","sponsor":"Peking Union Medical College Hospital","startDate":"2020-09-23","conditions":"Dexmedetomidine","enrollment":84},{"nctId":"NCT06219928","phase":"NA","title":"Comparison of the Effects of Dexmedetomidine and Ketamine Infusion on the Inflammatory Response in Liver Resection","status":"COMPLETED","sponsor":"Ataturk University","startDate":"2022-06-30","conditions":"Inflammation, Analgesia","enrollment":45},{"nctId":"NCT06685081","phase":"NA","title":"Dexmedetomidine for Improved Pain Relief and Recovery in Spine Surgery","status":"COMPLETED","sponsor":"Menoufia University","startDate":"2024-07-01","conditions":"Pain, Postoperative","enrollment":150},{"nctId":"NCT06633315","phase":"PHASE2","title":"Esketamine Combined With Dexmedetomidine Sedation in Head MRI Examination of Children With Autism Spectrum Disorder","status":"COMPLETED","sponsor":"Maternal and Child Health Hospital of Hubei Province","startDate":"2022-12-01","conditions":"Autism Spectrum Disorder, Dexmedetomidine, Esketamine","enrollment":300},{"nctId":"NCT03355053","phase":"PHASE2","title":"Investigation of Sleep in the Intensive Care Unit","status":"COMPLETED","sponsor":"Massachusetts General Hospital","startDate":"2018-05-29","conditions":"Delirium, Sleep","enrollment":522},{"nctId":"NCT06575179","phase":"PHASE4","title":"Dexmedetomidine Reduces Sevoflurane MAC-BAR During Pneumoperitoneum","status":"RECRUITING","sponsor":"Fujian Provincial Hospital","startDate":"2024-09-02","conditions":"Laparoscopic Cholecystectomy","enrollment":90},{"nctId":"NCT05688371","phase":"NA","title":"Dexmedetomidine Plus Low Dose Morphine Versus Standard Dose of Morphine in PCA in Children .","status":"RECRUITING","sponsor":"Beni-Suef University","startDate":"2023-02-01","conditions":"PCA, Children, Dexmedetomidine","enrollment":60},{"nctId":"NCT03809442","phase":"PHASE4","title":"Analgesic Efficacy of Ropivacaine Alone or in Combination With Adjuvants on Post-operative Analgesia Following Video-Assisted Thoracoscopic Surgery.","status":"COMPLETED","sponsor":"Aga Khan University","startDate":"2019-06-25","conditions":"Postoperative Analgesia","enrollment":116},{"nctId":"NCT06414941","phase":"NA","title":"The Effect of Dexmedetomidine and Esketamine Combined Infusion Quality of Sleep Undergoing Modified Radical Mastectomy","status":"RECRUITING","sponsor":"Anqing Municipal Hospital","startDate":"2024-05-15","conditions":"Dexmedetomidine Plus Esketamine Affect Postoperative Sleep Quality","enrollment":105},{"nctId":"NCT06392321","phase":"NA","title":"Dexmedetomidine vs Fentanyl in Controlling Labor Pain","status":"COMPLETED","sponsor":"Al-Azhar University","startDate":"2023-04-01","conditions":"Labor Pain","enrollment":90},{"nctId":"NCT06208956","phase":"NA","title":"A Low Dose Dexmedetomidine in Sedation Colonoscopy","status":"UNKNOWN","sponsor":"West China Hospital","startDate":"2024-01-20","conditions":"Colonoscopy","enrollment":104},{"nctId":"NCT05993975","phase":"PHASE4","title":"Effects of Intrathecal Dexmedetomidine as an Adjuvant to Low Dose Hyperbaric 0.5% Bupivacaine","status":"COMPLETED","sponsor":"Sindh Institute of Urology and Transplantation","startDate":"2021-07-20","conditions":"Post Operative Pain","enrollment":108},{"nctId":"NCT02633241","phase":"PHASE4","title":"A Pilot Study of Dexmedetomidine-Propofol in Children Undergoing Magnetic Resonance Imaging","status":"COMPLETED","sponsor":"Joseph Cravero","startDate":"2017-03-02","conditions":"Epilepsy, Cerebral Palsy, Developmental Delay","enrollment":71},{"nctId":"NCT05828199","phase":"PHASE1","title":"The Effect of Intraoperative Infusion of Dexmedetomidine Versus Low Dose Ketamine","status":"UNKNOWN","sponsor":"Al-Azhar University","startDate":"2022-12-01","conditions":"Nasal Polyps, Nasal Septum, Irregular, Functional Endoscopic Sinus Surgery","enrollment":80},{"nctId":"NCT05283408","phase":"NA","title":"The Clinical Study of Dexmedetomidine and Esketamine Combined Infusion Undergoing Modified Radical Mastectomy","status":"COMPLETED","sponsor":"Anqing Municipal Hospital","startDate":"2022-04-10","conditions":"Dexmedetomidine, Esketamine, Postoperative Pain and Recovery Quality","enrollment":135},{"nctId":"NCT04791059","phase":"PHASE4","title":"Low-dose S-ketamine and Dexmedetomidine in Combination With Opioids for Postoperative Analgesia","status":"COMPLETED","sponsor":"Peking University First Hospital","startDate":"2021-04-09","conditions":"Scoliosis Correction, Postoperative Analgesia, S-ketamine","enrollment":200},{"nctId":"NCT05647642","phase":"","title":"The Effect of Premedication on Postoperative Pain and Anxiety in Breast Cancer Surgery","status":"UNKNOWN","sponsor":"Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital","startDate":"2022-10-16","conditions":"Female Patients Under the Age of 65 Who Will Undergo Breast Cancer Surgery","enrollment":80},{"nctId":"NCT04237792","phase":"PHASE4","title":"Safety and Efficacy of Dexmedetomidine (DEX) for Sedation of Subjects ≥1 Month to <17 Years Undergoing MRI Scans","status":"COMPLETED","sponsor":"Pfizer","startDate":"2020-02-18","conditions":"MRI Sedation","enrollment":128},{"nctId":"NCT05111431","phase":"PHASE3","title":"A Trial of Dexmedetomidine Hydrochloride Nasal Spray in Preoperative Sedation of Children","status":"COMPLETED","sponsor":"Shanghai Hengrui Pharmaceutical Co., Ltd.","startDate":"2021-11-24","conditions":"Preoperative Sedation of Children","enrollment":159},{"nctId":"NCT05369949","phase":"PHASE4","title":"DEX vs SEVO in Congenital Heart Surgery","status":"NOT_YET_RECRUITING","sponsor":"Cliniques universitaires Saint-Luc- Université Catholique de Louvain","startDate":"2023-01-05","conditions":"Heart Defects, Congenital","enrollment":150},{"nctId":"NCT05514652","phase":"NA","title":"Anesthesia Standard Operating Procedure During On-pump Coronary Artery Bypass Grafting","status":"UNKNOWN","sponsor":"Heart Institute, Ministry of Health of Ukraine","startDate":"2018-12-01","conditions":"Coronary Artery Disease, Low Cardiac Output Syndrome, Atrial Fibrillation","enrollment":120},{"nctId":"NCT04817033","phase":"PHASE4","title":"Sedation Complications in Urology During Spinal Anesthesia With Dexmedetomidine or Midazolam Regarding OSA Risk","status":"COMPLETED","sponsor":"University Hospital of Split","startDate":"2021-04-01","conditions":"Anesthesia, Anesthesia Complication, Osa Syndrome","enrollment":115},{"nctId":"NCT04223219","phase":"PHASE4","title":"Different Modalities of Analgesia in Open Heart Surgeries in Mansoura University","status":"UNKNOWN","sponsor":"Mansoura University","startDate":"2019-12-10","conditions":"Coronary Artery Disease, Valve Disease, Heart, Pain, Acute","enrollment":90},{"nctId":"NCT03096730","phase":"NA","title":"Effect of Dexmedetomidine Combined With Low-dose Nalmefene on Preventing Remifentanil-induced Postoperative Hyperalgesia","status":"COMPLETED","sponsor":"Tianjin Medical University General Hospital","startDate":"2017-02-06","conditions":"Pain, Anesthesia","enrollment":150},{"nctId":"NCT04383418","phase":"PHASE2, PHASE3","title":"A Trial of Dexmedetomidine Hydrochloride Nasal Spray in Preoperative Sedation of Adults","status":"UNKNOWN","sponsor":"Jiangsu HengRui Medicine Co., Ltd.","startDate":"2020-05-31","conditions":"Preoperative Sedation","enrollment":201},{"nctId":"NCT04077398","phase":"PHASE4","title":"Volume vs Concentration: Quadratus Lumborum Blocks With High Volume/Low Concentration or Low Volume/ High Concentration in Nephrectomies","status":"WITHDRAWN","sponsor":"Bruce Ben-David","startDate":"2020-01-22","conditions":"Analgesia, Postoperative Pain, Block","enrollment":""},{"nctId":"NCT03388541","phase":"PHASE4","title":"Low Dose Dexmedetomidine and Delirium After Cardiac Surgery","status":"COMPLETED","sponsor":"Cliniques universitaires Saint-Luc- Université Catholique de Louvain","startDate":"2018-01-17","conditions":"Cardiac Surgical Procedures","enrollment":420},{"nctId":"NCT04200235","phase":"PHASE1","title":"A Trial of Dexmedetomidine Hydrochloride Nasal Spray in Preoperative Sedation of Children","status":"COMPLETED","sponsor":"Jiangsu HengRui Medicine Co., Ltd.","startDate":"2020-01-06","conditions":"Preoperative Sedation","enrollment":48},{"nctId":"NCT03378973","phase":"PHASE4","title":"The Effects of Dexmedetomidine Dose on Motor Evoked Potentials","status":"TERMINATED","sponsor":"Hospital for Special Surgery, New York","startDate":"2018-11-28","conditions":"Spinal Fusion","enrollment":7},{"nctId":"NCT03335527","phase":"PHASE4","title":"Impacts of Low-Dose Dexmedetomidine on Sleep Quality in Mechanically Ventilated ICU Patients","status":"COMPLETED","sponsor":"Peking University First Hospital","startDate":"2017-11-17","conditions":"Aged, Postoperative Period, Intensive Care Units","enrollment":80},{"nctId":"NCT03805945","phase":"PHASE4","title":"Effect of Dexmedetomidine on Parturient Undergoing Elective Cesarean Section.","status":"COMPLETED","sponsor":"The Affiliated Hospital of Xuzhou Medical University","startDate":"2019-06-01","conditions":"Cesarean Section","enrollment":160},{"nctId":"NCT02245256","phase":"PHASE4","title":"Efficacy of Low-dose Dexmedetomidine to Prevent Delirium in Liver Transplant Patients","status":"COMPLETED","sponsor":"Seoul National University Hospital","startDate":"2014-09-01","conditions":"Liver Transplantation","enrollment":217},{"nctId":"NCT04037774","phase":"PHASE4","title":"Comparision of Different Doses of Dexmedetomidine With Low Dose Bupivacaine in Selective Spinal Anesthesia.","status":"UNKNOWN","sponsor":"Services Institute of Medical Sciences, Pakistan","startDate":"2019-09-02","conditions":"Drug Effect","enrollment":75},{"nctId":"NCT03436472","phase":"NA","title":"Dexmedetomidine and 5-year Outcome in Elderly Patients After Surgery","status":"COMPLETED","sponsor":"Peking University First Hospital","startDate":"2017-06-01","conditions":"Aged, Operative, Delirium","enrollment":700},{"nctId":"NCT03775655","phase":"PHASE2, PHASE3","title":"Low Dose Hyperbaric Bupivacaine and Dexmedetomidine as an Adjuvant, Caesarean Section","status":"COMPLETED","sponsor":"Menoufia University","startDate":"2018-09-01","conditions":"Cesarean Section, Spinal Anesthesia, Dexmedetomidine","enrollment":40},{"nctId":"NCT00848393","phase":"PHASE2","title":"Measures to Lower the Stress Response in Pediatric Cardiac Surgery","status":"COMPLETED","sponsor":"Nationwide Children's Hospital","startDate":"2008-11","conditions":"Tetralogy of Fallot (TOF), Ventricular Septal Defects (VSD), Atrioventricular Septal Defects (AVSD)","enrollment":52},{"nctId":"NCT03302351","phase":"PHASE4","title":"Dexmedetomidine, Ketamine and Dexmetedomidine-Ketamine Combination for Control of Shivering During Regional Anaethesia","status":"COMPLETED","sponsor":"Assiut University","startDate":"2017-10-01","conditions":"Shivering","enrollment":94},{"nctId":"NCT03524950","phase":"PHASE3","title":"Effect of Dexmedetomidine on Stress Study of Pituitrin in Laparoscopic Hysteromyoma Surgery","status":"UNKNOWN","sponsor":"Beijing Anzhen Hospital","startDate":"2018-06-01","conditions":"Hysteromyoma","enrollment":90},{"nctId":"NCT02208505","phase":"PHASE4","title":"Antitussive Effect of Single-dose Dexmedetomidine With Low-dose Remifentanil Infusion","status":"COMPLETED","sponsor":"Yonsei University","startDate":"2014-02","conditions":"Thyroidectomy","enrollment":168},{"nctId":"NCT03312413","phase":"PHASE4","title":"Efficacy of Dexmedetomidine for Cough Suppression in Patients Undergoing Thyroid Surgery","status":"UNKNOWN","sponsor":"Min Su","startDate":"2017-08-10","conditions":"Anesthesia Complication","enrollment":400},{"nctId":"NCT02809937","phase":"PHASE4","title":"Dexmedetomidine and Long-term Outcome in Elderly Patients After Surgery","status":"COMPLETED","sponsor":"Peking University First Hospital","startDate":"2011-05","conditions":"Aged, Surgical Procedures, Operative, Delirium","enrollment":700},{"nctId":"NCT03132259","phase":"PHASE4","title":"Comparative Low and High Dose of Dexmedethomidine in Pituitary Tumor Removal by Transphenoid Approach","status":"UNKNOWN","sponsor":"Mahidol University","startDate":"2016-05","conditions":"Pituitary Tumor","enrollment":124},{"nctId":"NCT01736020","phase":"PHASE1","title":"Developing Anesthesia as Post Traumatic Stress Disorder (PTSD) Therapy","status":"UNKNOWN","sponsor":"Southern California Institute for Research and Education","startDate":"2009-09","conditions":"Healthy","enrollment":293},{"nctId":"NCT02630290","phase":"PHASE4","title":"Addition of Dexmedetomidine to Ropivacaine-induced Supraclavicular Block (ADRIB Trial)","status":"COMPLETED","sponsor":"Guangzhou First People's Hospital","startDate":"2015-12","conditions":"Radius Fractures, Ulna Fractures, Hand Injuries","enrollment":60},{"nctId":"NCT00936377","phase":"NA","title":"Dexmedetomidine as Adjunctive Therapy for Alcohol Withdrawal","status":"COMPLETED","sponsor":"University of Colorado, Denver","startDate":"2009-09","conditions":"Acute Alcohol Withdrawal","enrollment":24},{"nctId":"NCT02727712","phase":"PHASE4","title":"Studies of Application of Combined General Anesthesia and Bilateral TPVB in OPCABG","status":"UNKNOWN","sponsor":"Xiangya Hospital of Central South University","startDate":"2016-04","conditions":"Coronary Heart Disease","enrollment":60},{"nctId":"NCT00345384","phase":"PHASE1, PHASE2","title":"Dexmedetomidine for the Control of Post-Operative Pain in Thoracotomy Patients","status":"COMPLETED","sponsor":"Baylor Research Institute","startDate":"2008-05","conditions":"Post-operative Pain, Respiratory Depression","enrollment":38},{"nctId":"NCT02535273","phase":"PHASE4","title":"The Effect of Dexmedetomidine Analgesia and Sedation in Minimally Invasive Spine Surgery Under Local Anesthesia","status":"UNKNOWN","sponsor":"Tang-Du Hospital","startDate":"2015-09","conditions":"Spinal Diseases, Local Anesthesia","enrollment":212},{"nctId":"NCT00875550","phase":"PHASE3","title":"Study Evaluating Safety and Efficacy of Dexmedetomidine (DEX) in Intubated and Mechanically Ventilated Pediatric Intensive Care Unit (PICU) Subjects","status":"COMPLETED","sponsor":"Hospira, now a wholly owned subsidiary of Pfizer","startDate":"2010-01","conditions":"Sedation","enrollment":175},{"nctId":"NCT02518789","phase":"PHASE4","title":"Effects and Mechanism of Pretreatment With Dexmedetomidine to Etomidate Induce Myoclonus","status":"UNKNOWN","sponsor":"Tang-Du Hospital","startDate":"2015-09","conditions":"Myoclonus","enrollment":132},{"nctId":"NCT02239445","phase":"PHASE4","title":"Intranasal Dexmedetomidine VS Oral Chloral Hydrate for Rescue Sedation During Magnetic Resonance Imaging","status":"COMPLETED","sponsor":"Guangzhou Women and Children's Medical Center","startDate":"2014-09","conditions":"Administration Related Reaction, Failed Moderate Sedation During Procedure, Chloral Hydrate Adverse Reaction","enrollment":158},{"nctId":"NCT02327156","phase":"PHASE3","title":"Dexmedetomidine as an Adjuvant for Sub-Tenon's Anesthesia","status":"COMPLETED","sponsor":"Magrabi Eye & Ear Hospital","startDate":"2014-01","conditions":"Vitreoretinal Surgery Under Sub-Tenon's Anesthesia","enrollment":60},{"nctId":"NCT02220361","phase":"PHASE4","title":"Dexmedetomidine on Prevention of Side Effects of Hemabate","status":"UNKNOWN","sponsor":"Jin Ni","startDate":"2014-09","conditions":"Gynecological Patient","enrollment":120},{"nctId":"NCT02134093","phase":"PHASE4","title":"Effects of Dexmedetomidine on Postoperative Cognitive Dysfunction During One-lung Ventilation in Elder Patients","status":"UNKNOWN","sponsor":"Tang-Du Hospital","startDate":"2014-07","conditions":"Postoperative Confusion","enrollment":120},{"nctId":"NCT02007798","phase":"NA","title":"Small-dose Dexmedetomidine Effects on Recovery Profiles of Supratentorial Tumors Patients From General Anesthesia","status":"UNKNOWN","sponsor":"China Medical University, China","startDate":"2014-01","conditions":"Brain Neoplasms, Surgery","enrollment":150},{"nctId":"NCT00671931","phase":"PHASE1","title":"Susceptibility of Motor-Evoked Potentials to Varying Targeted Blood Levels of Dexmedetomidine","status":"COMPLETED","sponsor":"Children's Hospital Medical Center, Cincinnati","startDate":"2007-04","conditions":"Scoliosis","enrollment":44},{"nctId":"NCT01017237","phase":"PHASE4","title":"Dexmedetomidine Sedation With Third Molar Surgery","status":"TERMINATED","sponsor":"University of North Carolina, Chapel Hill","startDate":"2009-07","conditions":"Anesthesia","enrollment":18},{"nctId":"NCT01342562","phase":"NA","title":"The Effects of Intrathecal Dexmedetomidine on Spinal Anesthesia Using Diluted Low-Dose Bupivacaine for Transurethral Resection of Prostate in Elderly","status":"COMPLETED","sponsor":"Yonsei University","startDate":"2010-11","conditions":"Benign Prostatic Hypertrophy","enrollment":54},{"nctId":"NCT01704092","phase":"","title":"Dexmedetomidine's Cardiac and Cognitive Influence on Patients Undergoing Off-pump Coronary Artery Bypass Graft Surgery","status":"UNKNOWN","sponsor":"Huazhong University of Science and Technology","startDate":"2012-05","conditions":"Coronary Artery Disease","enrollment":90},{"nctId":"NCT00852046","phase":"PHASE4","title":"Adjunct Dexmedetomidine (Precedex®) Therapy Impact on Sedative and Analgesic Requirement","status":"WITHDRAWN","sponsor":"Avera McKennan Hospital & University Health Center","startDate":"2009-02","conditions":"Sedation, Analgesia","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":135,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Yisi"],"phase":"marketed","status":"active","brandName":"Low-dose Dexmedetomidine","genericName":"Low-dose Dexmedetomidine","companyName":"Tang-Du Hospital","companyId":"tang-du-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Low-dose dexmedetomidine is a selective alpha-2 adrenergic agonist that produces sedation, analgesia, and anxiolysis by activating presynaptic alpha-2 receptors in the central nervous system. Used for Sedation in intensive care unit (ICU) patients, Procedural sedation, Anxiolysis and analgesia in perioperative settings.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}