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Preemptive Dexmedetomidine injection
Dexmedetomidine is a selective alpha-2 adrenergic receptor agonist that produces sedation, analgesia, and anxiolysis by activating presynaptic and postsynaptic alpha-2 receptors in the central nervous system.
Dexmedetomidine is a selective alpha-2 adrenergic receptor agonist that produces sedation, analgesia, and anxiolysis by activating presynaptic and postsynaptic alpha-2 receptors in the central nervous system. Used for Preoperative sedation and anxiolysis, Perioperative analgesia and sedation, Reduction of anesthetic and opioid requirements during surgery.
At a glance
| Generic name | Preemptive Dexmedetomidine injection |
|---|---|
| Also known as | Preemptive Dex |
| Sponsor | China International Neuroscience Institution |
| Drug class | Alpha-2 adrenergic receptor agonist |
| Target | Alpha-2 adrenergic receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesia and Perioperative Medicine |
| Phase | FDA-approved |
Mechanism of action
Dexmedetomidine binds with high selectivity to alpha-2 adrenergic receptors, particularly in the locus coeruleus and other brainstem regions, leading to decreased norepinephrine release and reduced neuronal firing. This results in a unique sedative state characterized by maintained airway reflexes and the ability to be aroused, along with analgesic and anxiolytic effects. When used preemptively (before anesthesia or surgery), it reduces anxiety, decreases anesthetic requirements, and provides perioperative analgesia.
Approved indications
- Preoperative sedation and anxiolysis
- Perioperative analgesia and sedation
- Reduction of anesthetic and opioid requirements during surgery
Common side effects
- Hypotension
- Bradycardia
- Dry mouth
- Hypertension (transient, initial)
- Dizziness
Key clinical trials
- Analgesic Effect of Infraspinatus-teres Minor Block for Pre-emptive Analgesia in Patients Undergoing Shoulder Surgeries. (NA)
- Preemptive Analgesia Of Dexmedetomidine Reduces Per-operation Pain (PHASE4)
- The Effect of Dexmedetomidine for Suprascapular Nerve Block With Axillary Nerve Block (PHASE4)
- Comparative Study on the Effects of Epidural Dexmedetomidine on Heart Rate Variability During General Anesthesia in Patients Undergoing Gastrectomy (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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