{"id":"preemptive-dexmedetomidine-injection","safety":{"commonSideEffects":[{"rate":"10-30","effect":"Hypotension"},{"rate":"10-25","effect":"Bradycardia"},{"rate":"5-15","effect":"Dry mouth"},{"rate":"5-10","effect":"Hypertension (transient, initial)"},{"rate":"5-10","effect":"Dizziness"}]},"_chembl":{"chemblId":"CHEMBL2106195","moleculeType":"Small molecule","molecularWeight":"236.75"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dexmedetomidine binds with high selectivity to alpha-2 adrenergic receptors, particularly in the locus coeruleus and other brainstem regions, leading to decreased norepinephrine release and reduced neuronal firing. This results in a unique sedative state characterized by maintained airway reflexes and the ability to be aroused, along with analgesic and anxiolytic effects. When used preemptively (before anesthesia or surgery), it reduces anxiety, decreases anesthetic requirements, and provides perioperative analgesia.","oneSentence":"Dexmedetomidine is a selective alpha-2 adrenergic receptor agonist that produces sedation, analgesia, and anxiolysis by activating presynaptic and postsynaptic alpha-2 receptors in the central nervous system.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:02:18.725Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Preoperative sedation and anxiolysis"},{"name":"Perioperative analgesia and sedation"},{"name":"Reduction of anesthetic and opioid requirements during surgery"}]},"trialDetails":[{"nctId":"NCT06999460","phase":"NA","title":"Analgesic Effect of Infraspinatus-teres Minor Block for Pre-emptive Analgesia in Patients Undergoing Shoulder Surgeries.","status":"RECRUITING","sponsor":"Zagazig University","startDate":"2025-06-09","conditions":"Preemptive Analgesia","enrollment":60},{"nctId":"NCT06671327","phase":"PHASE4","title":"Preemptive Analgesia Of Dexmedetomidine Reduces Per-operation Pain","status":"NOT_YET_RECRUITING","sponsor":"China International Neuroscience Institution","startDate":"2025-04-03","conditions":"Pain Management, Noncardiac Surgery","enrollment":208},{"nctId":"NCT04398589","phase":"PHASE4","title":"The Effect of Dexmedetomidine for Suprascapular Nerve Block With Axillary Nerve Block","status":"COMPLETED","sponsor":"Chuncheon Sacred Heart Hospital","startDate":"2015-05-20","conditions":"Suprascapular Nerve Block, Axillary Nerve Block, Dexmedetomidine","enrollment":46},{"nctId":"NCT01857141","phase":"NA","title":"Comparative Study on the Effects of Epidural Dexmedetomidine on Heart Rate Variability During General Anesthesia in Patients Undergoing Gastrectomy","status":"COMPLETED","sponsor":"Yonsei University","startDate":"2012-02","conditions":"Gastric Cancer","enrollment":38}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Preemptive Dex"],"phase":"marketed","status":"active","brandName":"Preemptive Dexmedetomidine injection","genericName":"Preemptive Dexmedetomidine injection","companyName":"China International Neuroscience Institution","companyId":"china-international-neuroscience-institution","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dexmedetomidine is a selective alpha-2 adrenergic receptor agonist that produces sedation, analgesia, and anxiolysis by activating presynaptic and postsynaptic alpha-2 receptors in the central nervous system. Used for Preoperative sedation and anxiolysis, Perioperative analgesia and sedation, Reduction of anesthetic and opioid requirements during surgery.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}