Who is sponsoring NCT01857141?

NCT01857141 is sponsored by Yonsei University.

What condition does NCT01857141 study?

NCT01857141 studies Gastric Cancer.

What drugs are being tested in NCT01857141?

Interventions: preemptive dexmedetomidine epidural bolus injection(1.5 mcg/kg), normal saline.

What is the status of NCT01857141?

NCT01857141 is currently COMPLETED.

Last reviewed 2014-02-04 · How we verify

Comparative Study on the Effects of Epidural Dexmedetomidine on Heart Rate Variability During General Anesthesia in Patients Undergoing Gastrectomy

NCT01857141 NA COMPLETED

The use of epidural dexmedetomidine decreases the anaesthetic requirements and improved postoperative pain. Dexmedetomidine is a potent and highly selective a2-adrenoceptor agonist and has sympatholytic effect. Power spectral analysis of heart rate variability(HRV) is a useful tool to assess cardiac autonomic activity. We investigated whether preemptive epidural dexmedetomidine can develop hemodynamic change and it could be identify patients by HRV.

Details

Lead sponsor	Yonsei University
Phase	NA
Status	COMPLETED
Enrolment	38
Start date	2012-02
Completion	2013-08

Conditions

Gastric Cancer

Interventions

preemptive dexmedetomidine epidural bolus injection(1.5 mcg/kg)
normal saline

Primary outcomes

Heart rate variability analysis — 5min perioids after fluid resuscitation.
Heart rate variability analysis was performed according to the Task Force recommendations. Frequency domain analysis was based on fast Fourier transformation. Power spectrum densities were calculated for low frequencies (LF: 0.04-0.15 Hz) and high frequencies (HF: 0.15-0.4 Hz) informalized units, defined as the LF or HF proportional part of the total power. Baseline and 30min after the injection of the study drug.

Countries

South Korea