Opioid analgesic combination

This page covers all Opioid analgesic combination drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Opioid receptors (mu, delta, kappa); COX inhibition (acetaminophen), Mu opioid receptor (oxycodone); COX enzymes (paracetamol), Mu opioid receptor (codeine); COX enzymes (acetaminophen).

Targets

Opioid receptors (mu, delta, kappa); COX inhibition (acetaminophen) · Mu opioid receptor (oxycodone); COX enzymes (paracetamol) · Mu opioid receptor (codeine); COX enzymes (acetaminophen) · Mu opioid receptor (hydrocodone component); prostaglandin synthesis inhibition (acetaminophen component) · Mu opioid receptor (hydrocodone); COX inhibitor (acetaminophen) · Opioid receptors (mu, kappa, delta) · Mu-opioid receptor (morphine); H1 histamine receptor (promethazine) · Mu opioid receptor (codeine); cyclooxygenase enzymes (acetaminophen) · Mu-opioid receptor; norepinephrine and serotonin transporters; COX enzymes · Mu opioid receptor; norepinephrine transporter; serotonin transporter; cyclooxygenase

Marketed (30)

• Norco 5milligram-325milligram Tablet · Wake Forest University Health Sciences · Pain Management
  Norco combines hydrocodone (an opioid agonist) with acetaminophen to provide pain relief through central nervous system depression and peripheral analgesic effects.
• PCM/Oxy2 · Maastricht University Medical Center · Pain Management
  PCM/Oxy2 is a fixed-dose combination of paracetamol (acetaminophen) and oxycodone that provides analgesia through dual mechanisms: paracetamol's antipyretic and analgesic effects via COX inhibition, and oxycodone's opioid receptor agonism for moderate-to-severe pain relief.
• Acetaminophen/Codeine · University of Pennsylvania · Pain Management
  Acetaminophen reduces fever and pain through central nervous system effects, while codeine is an opioid that binds to opioid receptors to provide additional analgesic and antitussive effects.
• Acetaminophen-Hydrocodone · Le Bonheur Children's Hospital · Pain Management
  Acetaminophen reduces fever and pain through central nervous system effects, while hydrocodone is an opioid agonist that binds to mu opioid receptors to provide additional pain relief.
• hydrocodone/APAP · VA Office of Research and Development · Pain Management
  Hydrocodone is an opioid agonist that binds to mu opioid receptors in the central nervous system to reduce pain, while acetaminophen (APAP) inhibits prostaglandin synthesis to provide additional analgesic and antipyretic effects.
• Nalbuphine and morphine · National Taiwan University Hospital · Pain management
  Nalbuphine and morphine are opioid agonists that bind to opioid receptors in the central nervous system to produce analgesia and pain relief.
• Morphine-Promethazine · Tel-Aviv Sourasky Medical Center · Pain Management
  Morphine provides opioid analgesia while promethazine enhances pain relief and reduces nausea through antihistamine and anticholinergic effects.
• Tylenol with codeine · National Center for Complementary and Integrative Health (NCCIH) · Pain Management
  Acetaminophen reduces fever and mild-to-moderate pain through inhibition of prostaglandin synthesis, while codeine is an opioid agonist that enhances pain relief through central nervous system depression.
• Ultracet® · Labopharm Inc. · Pain Management
  Ultracet combines tramadol (an opioid agonist and monoamine reuptake inhibitor) with acetaminophen to provide enhanced pain relief through dual analgesic pathways.
• Tramadol /acetaminophen · Johnson & Johnson Taiwan Ltd · Pain Management
  Tramadol inhibits norepinephrine and serotonin reuptake while acting as a weak opioid agonist, and acetaminophen inhibits prostaglandin synthesis to provide combined analgesic and antipyretic effects.
• Tramadol hydrochloride/ Acetaminophen · Janssen Korea, Ltd., Korea · Pain Management
  Tramadol inhibits norepinephrine and serotonin reuptake while acting as a weak opioid agonist, and acetaminophen reduces pain through central analgesic and antipyretic effects.
• hydrocodone/APAP w placebo PRN · VA Office of Research and Development · Pain Management
  Hydrocodone is an opioid agonist that binds to mu opioid receptors in the central nervous system to reduce pain perception, while acetaminophen (APAP) inhibits prostaglandin synthesis to provide additional analgesic and antipyretic effects.
• Codeine/acetaminophen · Montefiore Medical Center · Pain Management
  Codeine is converted to morphine in the body to activate opioid receptors for pain relief, while acetaminophen inhibits prostaglandin synthesis to reduce pain and fever.
• oxycodone/APAP · Albert Einstein College of Medicine · Pain Management
  Oxycodone binds to opioid receptors in the central nervous system to reduce pain perception, while acetaminophen inhibits prostaglandin synthesis to provide additional analgesic and antipyretic effects.
• hydroxycontin/acetominophen · University of Rochester · Pain Management
  Hydrocodone (an opioid agonist) combined with acetaminophen provides analgesia through mu-opioid receptor activation and cyclooxygenase inhibition.
• PCM/Oxy1 · Maastricht University Medical Center · Pain Management
  PCM/Oxy1 is a fixed-dose combination of paracetamol (acetaminophen) and oxycodone that provides analgesia through dual mechanisms: paracetamol's antipyretic and analgesic effects via COX inhibition, and oxycodone's opioid receptor agonism for moderate to severe pain relief.
• Zaldiar® · Labopharm Inc. · Pain Management
  Zaldiar combines tramadol (an opioid agonist and monoamine reuptake inhibitor) with paracetamol (acetaminophen) to provide analgesia through dual pathways.
• hydrocodone, acetaminophen and ibuprofen · Albany Medical College · Pain Management
  This combination drug provides pain relief through three complementary mechanisms: hydrocodone acts as an opioid agonist, acetaminophen inhibits prostaglandin synthesis, and ibuprofen inhibits cyclooxygenase enzymes.
• hydrocodone plus acetaminophen · University of California, Davis · Pain Management
  Hydrocodone is an opioid agonist that binds to mu opioid receptors in the central nervous system to reduce pain perception, while acetaminophen inhibits prostaglandin synthesis to provide additional analgesic and antipyretic effects.
• Hydrocodone-Acetaminophen · Henry Ford Health System · Pain Management
  Hydrocodone is an opioid agonist that binds to mu opioid receptors in the central nervous system to reduce pain perception, while acetaminophen inhibits prostaglandin synthesis to provide additional analgesic and antipyretic effects.
• Codeine paracetamol · Napp Pharmaceuticals Limited · Pain Management
  Codeine acts as a weak opioid agonist while paracetamol inhibits prostaglandin synthesis, together providing analgesic and antipyretic effects.
• Oxycodone and acetaminophen combination treatment · Barrie Urology Associates · Pain Management
  Oxycodone binds to opioid receptors to reduce pain perception, while acetaminophen inhibits prostaglandin synthesis to provide additional analgesic and antipyretic effects.
• Tramadol HCI/acetaminophen · Janssen-Cilag Ltd.,Thailand · Pain Management
  Tramadol inhibits norepinephrine and serotonin reuptake while weakly binding opioid receptors, while acetaminophen inhibits prostaglandin synthesis to provide combined analgesic and antipyretic effects.
• Ultracet Tablets · Pfizer · Pain Management
  Ultracet combines tramadol (an opioid agonist and monoamine reuptake inhibitor) with acetaminophen to provide analgesia through dual pathways of pain relief.
• Codeine with acetaminophen · Children's Hospitals and Clinics of Minnesota · Pain Management
  Codeine is an opioid agonist that binds to mu opioid receptors to reduce pain perception, while acetaminophen inhibits prostaglandin synthesis to provide additional analgesic and antipyretic effects.
• Oxycontin/acetominophen · University of Rochester · Pain Management
  Oxycodone (an opioid agonist) binds to mu opioid receptors to reduce pain, while acetaminophen inhibits prostaglandin synthesis to provide additional analgesic and antipyretic effects.
• placebo with hydrocodone/APAP PRN · VA Office of Research and Development · Pain Management
  Hydrocodone is an opioid agonist that binds to mu opioid receptors in the central nervous system to reduce pain perception, while acetaminophen (APAP) inhibits prostaglandin synthesis to provide additional analgesic and antipyretic effects.
• Oxycodone and acetaminophen · University of Puerto Rico · Pain Management
  Oxycodone binds to opioid receptors to reduce pain perception, while acetaminophen inhibits prostaglandin synthesis to provide additional analgesic and antipyretic effects.
• Tramadol HCl-Paracetamol · Xian-Janssen Pharmaceutical Ltd. · Pain Management
  This combination drug reduces pain through dual action: tramadol inhibits monoamine reuptake and activates opioid receptors, while paracetamol inhibits prostaglandin synthesis.
• Oxycodone/ acetaminophen · Montefiore Medical Center · Pain Management
  Oxycodone binds to opioid receptors in the central nervous system to reduce pain perception, while acetaminophen inhibits prostaglandin synthesis to provide additional analgesic and antipyretic effects.

Phase 3 pipeline (7)

• Tramadol hydrochloride/Acetaminophen Tab. · Daewon Pharmaceutical Co., Ltd. · Pain Management
  Tramadol inhibits norepinephrine and serotonin reuptake while acting as a weak opioid agonist, and acetaminophen reduces pain through central analgesic and antipyretic effects.
• OXY/APAP · Purdue Pharma LP · Pain Management
  OXY/APAP combines oxycodone (an opioid analgesic) with acetaminophen (a non-opioid analgesic) to provide enhanced pain relief through dual mechanisms.
• Comparator: oxycodone and acetaminophen · Merck Sharp & Dohme LLC · Pain Management
  This is a fixed-dose combination of oxycodone (a mu-opioid receptor agonist) and acetaminophen (a non-opioid analgesic) that provides pain relief through dual mechanisms.
• Hydrocodone/Acetaminophen on Extended Release · Abbott · Pain Management
  Hydrocodone is an opioid agonist that binds to mu opioid receptors in the central nervous system to reduce pain, while acetaminophen inhibits prostaglandin synthesis to provide additional analgesic and antipyretic effects.
• Comparator: acetaminophen + codeine · Organon and Co · Pain Management
  Acetaminophen reduces fever and pain through central nervous system effects, while codeine is an opioid agonist that enhances analgesia and suppresses cough.
• Norco Pill · Rothman Institute Orthopaedics · Pain Management
  Norco combines hydrocodone (an opioid agonist) with acetaminophen to provide pain relief through central nervous system depression and peripheral analgesic effects.
• Percocet Pill · Rothman Institute Orthopaedics · Pain Management
  Percocet combines oxycodone (an opioid agonist) and acetaminophen to provide pain relief through central nervous system depression and peripheral analgesic effects.