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oxycodone/APAP

Albert Einstein College of Medicine · FDA-approved active Small molecule

Oxycodone binds to opioid receptors in the central nervous system to reduce pain perception, while acetaminophen inhibits prostaglandin synthesis to provide additional analgesic and antipyretic effects.

Oxycodone binds to opioid receptors in the central nervous system to reduce pain perception, while acetaminophen inhibits prostaglandin synthesis to provide additional analgesic and antipyretic effects. Used for Moderate to moderately severe acute pain, Chronic pain management.

At a glance

Generic nameoxycodone/APAP
Also known asPercocet
SponsorAlbert Einstein College of Medicine
Drug classOpioid analgesic combination
TargetOpioid receptors (mu, delta, kappa); cyclooxygenase enzymes
ModalitySmall molecule
Therapeutic areaPain Management
PhaseFDA-approved

Mechanism of action

Oxycodone is a semi-synthetic opioid agonist that acts on mu, delta, and kappa opioid receptors, primarily in the brain and spinal cord, to modulate pain signaling. Acetaminophen (APAP) works through a separate mechanism by inhibiting cyclooxygenase enzymes and reducing prostaglandin production, providing complementary analgesia. The combination allows for lower opioid doses while maintaining effective pain relief.

Approved indications

Common side effects

Key clinical trials

Primary sources

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SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results