Last reviewed · How we verify
hydrocodone, acetaminophen and ibuprofen
This combination drug provides pain relief through three complementary mechanisms: hydrocodone acts as an opioid agonist, acetaminophen inhibits prostaglandin synthesis, and ibuprofen inhibits cyclooxygenase enzymes.
This combination drug provides pain relief through three complementary mechanisms: hydrocodone acts as an opioid agonist, acetaminophen inhibits prostaglandin synthesis, and ibuprofen inhibits cyclooxygenase enzymes. Used for Moderate to moderately severe pain.
At a glance
| Generic name | hydrocodone, acetaminophen and ibuprofen |
|---|---|
| Also known as | no other intervention names applicable |
| Sponsor | Albany Medical College |
| Drug class | Opioid analgesic combination |
| Target | Opioid receptors (hydrocodone); COX-1/COX-2 (ibuprofen); unclear (acetaminophen) |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | FDA-approved |
Mechanism of action
Hydrocodone binds to opioid receptors in the central nervous system to reduce pain perception. Acetaminophen and ibuprofen are both analgesics and antipyretics that work through different pathways—acetaminophen's exact mechanism is not fully understood but involves central nervous system effects, while ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces inflammation and pain by inhibiting COX-1 and COX-2 enzymes. The combination provides synergistic pain relief for moderate to moderately severe pain.
Approved indications
- Moderate to moderately severe pain
Common side effects
- Dizziness
- Drowsiness
- Nausea
- Constipation
- Gastrointestinal upset
- Respiratory depression
Key clinical trials
- Post-operative Pain Management in Children With Supracondylar Humerus Fractures (PHASE4)
- SCHF Post-Op Study Between Opioid and Non-Opioid Pain Management (PHASE4)
- Opioid Analgesic Reduction Study (PHASE3)
- RCT: Suzetrigine vs Norco for Post-op Pain (PHASE4)
- Prospective Opioid-Free AIS Fusion (PHASE4)
- Efficacy of Ketamine for Improvement in Postoperative Pain Control After Spinal Fusion for Idiopathic Scoliosis (PHASE4)
- Scheduled or As Needed Pain Regimen? (PHASE4)
- ICE-T Pain Regimen for Total Laparoscopic Hysterectomy (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape: