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Tramadol hydrochloride/ Acetaminophen
Tramadol inhibits norepinephrine and serotonin reuptake while acting as a weak opioid agonist, and acetaminophen reduces pain through central analgesic and antipyretic effects.
Tramadol inhibits norepinephrine and serotonin reuptake while acting as a weak opioid agonist, and acetaminophen reduces pain through central analgesic and antipyretic effects. Used for Moderate pain.
At a glance
| Generic name | Tramadol hydrochloride/ Acetaminophen |
|---|---|
| Also known as | Ultracet |
| Sponsor | Janssen Korea, Ltd., Korea |
| Drug class | Opioid analgesic combination |
| Target | Mu-opioid receptor; norepinephrine transporter; serotonin transporter |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | FDA-approved |
Mechanism of action
Tramadol is a synthetic opioid that works through dual mechanisms: it binds to mu-opioid receptors and also inhibits the reuptake of norepinephrine and serotonin in the central nervous system, enhancing pain modulation. Acetaminophen complements this by inhibiting prostaglandin synthesis in the CNS, providing additional analgesic and antipyretic activity. The combination provides enhanced pain relief for moderate pain conditions.
Approved indications
- Moderate pain
Common side effects
- Dizziness
- Nausea
- Constipation
- Headache
- Somnolence
- Vomiting
Key clinical trials
- Analgesic Efficacy and Obstetric Effects of Tramadol, Paracetamol and Placebo in Active Labor (PHASE4)
- Opioid-Free Pain Protocol After Shoulder Arthroplasty (PHASE4)
- Intravenous Paracetamol Versus Intramuscular Tramadol in Shortening the Duration of Labour. (NA)
- Combined Intravenous Tramadol and Paracetamol Versus Intramuscular Pethidine for Pain Relief During the First Stage of Labor. Compare the Efficacy and Adverse Effects (NA)
- Investigation of the Effect of Proximal and Distal Adductor Canal Block in Knee Replacement Surgery (NA)
- Impact of Opioid Avoidance Protocol for ACL Reconstruction
- Paracetamol-Tramadol and Paracetamol-caffeine Versus Placebo in the Emergency Discharge Treatment of Renal Colic (PHASE2)
- Perioperative Polmacoxib Reduce Opioid Consumption for Post Operative Pain After Rotator Cuff Tear. (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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