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Tramadol HCI/acetaminophen
Tramadol inhibits norepinephrine and serotonin reuptake while weakly binding opioid receptors, while acetaminophen inhibits prostaglandin synthesis to provide combined analgesic and antipyretic effects.
Tramadol inhibits norepinephrine and serotonin reuptake while weakly binding opioid receptors, while acetaminophen inhibits prostaglandin synthesis to provide combined analgesic and antipyretic effects. Used for Moderate to moderately severe pain.
At a glance
| Generic name | Tramadol HCI/acetaminophen |
|---|---|
| Also known as | Ultracet, ULTRACET immediate release tablet, YJAT sustained release tablet |
| Sponsor | Janssen-Cilag Ltd.,Thailand |
| Drug class | Opioid analgesic combination |
| Target | Mu opioid receptor, norepinephrine transporter, serotonin transporter, COX inhibition |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | FDA-approved |
Mechanism of action
Tramadol is a synthetic opioid analgesic that works through dual mechanisms: it blocks the reuptake of norepinephrine and serotonin in the central nervous system and has weak mu-opioid receptor agonist activity. Acetaminophen (paracetamol) is a non-opioid analgesic and antipyretic that inhibits prostaglandin synthesis, primarily in the central nervous system. The combination provides enhanced pain relief through complementary mechanisms.
Approved indications
- Moderate to moderately severe pain
Common side effects
- Dizziness
- Nausea
- Constipation
- Headache
- Somnolence
- Vomiting
- Pruritus
Key clinical trials
- Assessment of the Pharmacokinetics of a Sustained Release Formulation of a Tramadol/Acetaminophen Combination (PHASE1)
- A Study of Safety and Effectiveness of Ultracet in Patients With Chronic Cancer Pain (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Tramadol HCI/acetaminophen CI brief — competitive landscape report
- Tramadol HCI/acetaminophen updates RSS · CI watch RSS
- Janssen-Cilag Ltd.,Thailand portfolio CI