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Tramadol HCI/acetaminophen — Competitive Intelligence Brief

Tramadol HCI/acetaminophen (Tramadol HCI/acetaminophen) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Opioid analgesic combination. Area: Pain Management.

marketed Opioid analgesic combination Mu opioid receptor, norepinephrine transporter, serotonin transporter, COX inhibition Pain Management Small molecule Live · refreshed every 30 min

Target snapshot

Tramadol HCI/acetaminophen (Tramadol HCI/acetaminophen) — Janssen-Cilag Ltd.,Thailand. Tramadol inhibits norepinephrine and serotonin reuptake while weakly binding opioid receptors, while acetaminophen inhibits prostaglandin synthesis to provide combined analgesic and antipyretic effects.

Comparator set (6 drugs)

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DrugGenericSponsorPhaseClassTargetApproval / PDUFA
Tramadol HCI/acetaminophen TARGET Tramadol HCI/acetaminophen Janssen-Cilag Ltd.,Thailand marketed Opioid analgesic combination Mu opioid receptor, norepinephrine transporter, serotonin transporter, COX inhibition
BENZHYDROCODONE BENZHYDROCODONE marketed Opioid analgesic combination; full mu-opioid agonist with non-opioid analgesic Mu-opioid receptors (primary); delta and kappa opioid receptors (secondary); central nervous system pain pathways 2018-01-01
Codeine/acetaminophen Codeine/acetaminophen Montefiore Medical Center marketed Opioid analgesic combination Mu-opioid receptor (codeine); COX enzymes (acetaminophen)
hydrocodone/APAP hydrocodone/APAP VA Office of Research and Development marketed Opioid analgesic combination Mu opioid receptor (hydrocodone); COX inhibitor (acetaminophen)
Morphine-Promethazine Morphine-Promethazine Tel-Aviv Sourasky Medical Center marketed Opioid analgesic combination Mu-opioid receptor (morphine); H1 histamine receptor (promethazine)
Tylenol with codeine Tylenol with codeine National Center for Complementary and Integrative Health (NCCIH) marketed Opioid analgesic combination Mu opioid receptor (codeine); cyclooxygenase enzymes (acetaminophen)
Tramadol HCl/acetaminophen Extended Release Tramadol HCl/acetaminophen Extended Release Janssen Korea, Ltd., Korea marketed Opioid analgesic combination with NSAID alternative Mu-opioid receptor; norepinephrine transporter; serotonin transporter

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Opioid analgesic combination class)

  1. VA Office of Research and Development · 3 drugs in this class
  2. Rothman Institute Orthopaedics · 2 drugs in this class
  3. Labopharm Inc. · 2 drugs in this class
  4. University of Rochester · 2 drugs in this class
  5. Montefiore Medical Center · 2 drugs in this class
  6. Maastricht University Medical Center · 2 drugs in this class
  7. Henry Ford Health System · 1 drug in this class
  8. Daewon Pharmaceutical Co., Ltd. · 1 drug in this class
  9. Albert Einstein College of Medicine · 1 drug in this class
  10. Johnson & Johnson Taiwan Ltd · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Tramadol HCI/acetaminophen — Competitive Intelligence Brief. https://druglandscape.com/ci/tramadol-hci-acetaminophen. Accessed 2026-05-16.

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