{"id":"tramadol-hci-acetaminophen","safety":{"commonSideEffects":[{"rate":"15-25","effect":"Dizziness"},{"rate":"10-20","effect":"Nausea"},{"rate":"10-15","effect":"Constipation"},{"rate":"5-10","effect":"Headache"},{"rate":"5-10","effect":"Somnolence"},{"rate":"5-10","effect":"Vomiting"},{"rate":"5-8","effect":"Pruritus"}]},"_chembl":{"chemblId":"CHEMBL1237065","moleculeType":"Small molecule","molecularWeight":"299.84"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Tramadol is a synthetic opioid analgesic that works through dual mechanisms: it blocks the reuptake of norepinephrine and serotonin in the central nervous system and has weak mu-opioid receptor agonist activity. Acetaminophen (paracetamol) is a non-opioid analgesic and antipyretic that inhibits prostaglandin synthesis, primarily in the central nervous system. The combination provides enhanced pain relief through complementary mechanisms.","oneSentence":"Tramadol inhibits norepinephrine and serotonin reuptake while weakly binding opioid receptors, while acetaminophen inhibits prostaglandin synthesis to provide combined analgesic and antipyretic effects.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:13:26.489Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Moderate to moderately severe pain"}]},"trialDetails":[{"nctId":"NCT01880125","phase":"PHASE1","title":"Assessment of the Pharmacokinetics of a Sustained Release Formulation of a Tramadol/Acetaminophen Combination","status":"COMPLETED","sponsor":"Yungjin Pharm. Co., Ltd.","startDate":"2012-01","conditions":"Pain","enrollment":24},{"nctId":"NCT01968018","phase":"PHASE4","title":"A Study of Safety and Effectiveness of Ultracet in Patients With Chronic Cancer Pain","status":"COMPLETED","sponsor":"Janssen-Cilag Ltd.,Thailand","startDate":"2004-07","conditions":"Cancer","enrollment":35}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Ultracet","ULTRACET immediate release tablet","YJAT sustained release tablet"],"phase":"marketed","status":"active","brandName":"Tramadol HCI/acetaminophen","genericName":"Tramadol HCI/acetaminophen","companyName":"Janssen-Cilag Ltd.,Thailand","companyId":"janssen-cilag-ltd-thailand","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Tramadol inhibits norepinephrine and serotonin reuptake while weakly binding opioid receptors, while acetaminophen inhibits prostaglandin synthesis to provide combined analgesic and antipyretic effects. Used for Moderate to moderately severe pain.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}