Last reviewed 2026-04-22 · How we verify

Ultracet Tablets

Ultracet combines tramadol (an opioid agonist and monoamine reuptake inhibitor) with acetaminophen to provide analgesia through dual pathways of pain relief.

Ultracet combines tramadol (an opioid agonist and monoamine reuptake inhibitor) with acetaminophen to provide analgesia through dual pathways of pain relief. Used for Moderate acute pain in adults.

At a glance

Mechanism of action

Tramadol acts as a weak mu-opioid receptor agonist and inhibits the reuptake of norepinephrine and serotonin, enhancing descending pain inhibitory pathways. Acetaminophen works through poorly understood mechanisms involving central COX inhibition and endocannabinoid system modulation. Together, these agents provide synergistic pain relief for moderate acute pain.

Approved indications

• Moderate acute pain in adults

Common side effects

• Dizziness
• Nausea
• Constipation
• Headache
• Somnolence
• Pruritus
• Vomiting

Key clinical trials

• Paracetamol-Tramadol and Paracetamol-caffeine Versus Placebo in the Emergency Discharge Treatment of Renal Colic (PHASE2)
• Perioperative Polmacoxib Reduce Opioid Consumption for Post Operative Pain After Rotator Cuff Tear. (NA)
• Tramadol-paracetamol Combination in Treatment of Patients Undergoing Spinal Surgery (PHASE4)
• Efficacy and Safety of Fixed-dose Combination of Etoricoxib/Tramadol vs Acetaminophen/Tramadol for Acute Low Back Pain (PHASE3)
• Assessment of the Pharmacokinetics of a Sustained Release Formulation of a Tramadol/Acetaminophen Combination (PHASE1)
• Bioequivalence Study of Tramadol Hydrochloride /Paracetamol Tablets Versus Ultracet Tablets (PHASE4)
• Bioavailability Study of Tramadol/APAP Tablets Under Fed Conditions (PHASE1)
• Effect of Combined Use of Naloxone and Tramacet on Postop Analgesia in Elderly Patients Having Joint Replacement Surgery (PHASE3)

Primary sources

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