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Tramadol hydrochloride/Acetaminophen Tab.
Tramadol inhibits norepinephrine and serotonin reuptake while acting as a weak opioid agonist, and acetaminophen reduces pain through central analgesic and antipyretic effects.
Tramadol inhibits norepinephrine and serotonin reuptake while acting as a weak opioid agonist, and acetaminophen reduces pain through central analgesic and antipyretic effects. Used for Moderate to moderately severe acute pain.
At a glance
| Generic name | Tramadol hydrochloride/Acetaminophen Tab. |
|---|---|
| Sponsor | Daewon Pharmaceutical Co., Ltd. |
| Drug class | Opioid analgesic combination |
| Target | Mu-opioid receptor; norepinephrine transporter; serotonin transporter |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | Phase 3 |
Mechanism of action
Tramadol is a synthetic opioid that works through dual mechanisms: it binds to mu-opioid receptors and inhibits the reuptake of norepinephrine and serotonin in the central nervous system, enhancing pain modulation. Acetaminophen complements this by inhibiting prostaglandin synthesis in the CNS, providing additional analgesic and antipyretic activity. The combination provides enhanced pain relief for moderate to moderately severe pain.
Approved indications
- Moderate to moderately severe acute pain
Common side effects
- Nausea
- Dizziness
- Constipation
- Headache
- Somnolence
- Vomiting
- Pruritus
Key clinical trials
- Paracetamol-Tramadol and Paracetamol-caffeine Versus Placebo in the Emergency Discharge Treatment of Renal Colic (PHASE2)
- Perioperative Polmacoxib Reduce Opioid Consumption for Post Operative Pain After Rotator Cuff Tear. (NA)
- Tramadol-paracetamol Combination in Treatment of Patients Undergoing Spinal Surgery (PHASE4)
- Proof-of-concept Study to Assess the Efficacy, Tolerability and Safety of a Single Intraarticular Dose of GZ389988 Versus Placebo in Patients With Painful Osteoarthritis of the Knee (PHASE2)
- Efficacy and Safety of Fixed-dose Combination of Etoricoxib/Tramadol vs Acetaminophen/Tramadol for Acute Low Back Pain (PHASE3)
- Multimodal Analgesia in Shoulder Arthroplasty (PHASE3)
- Assessment of the Pharmacokinetics of a Sustained Release Formulation of a Tramadol/Acetaminophen Combination (PHASE1)
- Tramadol Hydrochloride and Dexketoprofen Trometamol for the Oral Treatment of Moderate to Severe Acute Pain Following Removal of Impacted Lower Third Molar (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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