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Tramadol /acetaminophen
Tramadol /acetaminophen is a Opioid analgesic combination Small molecule drug developed by Johnson & Johnson Taiwan Ltd. It is currently FDA-approved for Moderate pain management, Post-operative pain. Also known as: Ultracet®.
Tramadol inhibits norepinephrine and serotonin reuptake while acting as a weak opioid agonist, and acetaminophen inhibits prostaglandin synthesis to provide combined analgesic and antipyretic effects.
Tramadol is a small molecule that acts as a mu opioid receptor agonist, classified as an agonist. It is used to treat conditions such as postoperative pain, pain, and fibromyalgia, as well as being studied in multimodal analgesic approaches.
At a glance
| Generic name | Tramadol /acetaminophen |
|---|---|
| Also known as | Ultracet® |
| Sponsor | Johnson & Johnson Taiwan Ltd |
| Drug class | Opioid analgesic combination |
| Target | Mu opioid receptor; norepinephrine transporter; serotonin transporter; cyclooxygenase |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | FDA-approved |
Mechanism of action
Tramadol is a synthetic opioid that works through dual mechanisms: it binds to mu opioid receptors and also inhibits the reuptake of norepinephrine and serotonin in the central nervous system, enhancing pain modulation. Acetaminophen reduces pain and fever by inhibiting cyclooxygenase enzymes and prostaglandin synthesis. The combination provides enhanced analgesia for moderate pain management.
Approved indications
- Moderate pain management
- Post-operative pain
Common side effects
- Dizziness
- Nausea
- Constipation
- Headache
- Somnolence
- Vomiting
Key clinical trials
- The Efficiency of Periarticular Multimodal Drug Injection in Pain Management Following Primary Unilateral TKA (NA)
- Analgesic Efficacy and Obstetric Effects of Tramadol, Paracetamol and Placebo in Active Labor (PHASE4)
- NonNarcotic Pain Control in Percutaneous Needle Tenotomy of Elbow (PHASE4)
- Opioid-Free Pain Protocol After Shoulder Arthroplasty (PHASE4)
- Intravenous Paracetamol Versus Intramuscular Tramadol in Shortening the Duration of Labour. (NA)
- Efficacy of Intercostal CryoAnalgesia in Robotic Lung Resection (PHASE4)
- Adding Dexmedetomidine or Tramadol to Paracetamol- An Effort to Attenuate Catheter Related Bladder Discomfort (PHASE3)
- Effectiveness of AI-Guided Exercise and Pain Neuroscience Education for Fibromyalgia (FIBROIA) (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Tramadol /acetaminophen CI brief — competitive landscape report
- Tramadol /acetaminophen updates RSS · CI watch RSS
- Johnson & Johnson Taiwan Ltd portfolio CI
Frequently asked questions about Tramadol /acetaminophen
What is Tramadol /acetaminophen?
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Is Tramadol /acetaminophen also known as anything else?
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What does Tramadol /acetaminophen target?
Related
- Drug class: All Opioid analgesic combination drugs
- Target: All drugs targeting Mu opioid receptor; norepinephrine transporter; serotonin transporter; cyclooxygenase
- Manufacturer: Johnson & Johnson Taiwan Ltd — full pipeline
- Therapeutic area: All drugs in Pain Management
- Indication: Drugs for Moderate pain management
- Indication: Drugs for Post-operative pain
- Also known as: Ultracet®
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing