Tramadol /acetaminophen — Competitive Intelligence Brief

Tramadol /acetaminophen (Tramadol /acetaminophen) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Opioid analgesic combination. Area: Pain Management.

marketed Opioid analgesic combination Mu opioid receptor; norepinephrine transporter; serotonin transporter; cyclooxygenase Pain Management Small molecule

Target snapshot

Tramadol /acetaminophen (Tramadol /acetaminophen) — Johnson & Johnson Taiwan Ltd. Tramadol inhibits norepinephrine and serotonin reuptake while acting as a weak opioid agonist, and acetaminophen inhibits prostaglandin synthesis to provide combined analgesic and antipyretic effects.

Comparator set (6 drugs)

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Tramadol /acetaminophen TARGET	Tramadol /acetaminophen	Johnson & Johnson Taiwan Ltd	marketed	Opioid analgesic combination	Mu opioid receptor; norepinephrine transporter; serotonin transporter; cyclooxygenase
BENZHYDROCODONE	BENZHYDROCODONE		marketed	Opioid analgesic combination; full mu-opioid agonist with non-opioid analgesic	Mu-opioid receptors (primary); delta and kappa opioid receptors (secondary); central nervous system pain pathways	2018-01-01
placebo with hydrocodone/APAP PRN	placebo with hydrocodone/APAP PRN	VA Office of Research and Development	marketed	Opioid analgesic combination	Mu opioid receptor (hydrocodone); COX enzymes (acetaminophen)
hydrocodone plus acetaminophen	hydrocodone plus acetaminophen	University of California, Davis	marketed	Opioid analgesic combination	Mu opioid receptor (hydrocodone); COX inhibitor (acetaminophen)
Hydrocodone-Acetaminophen	Hydrocodone-Acetaminophen	Henry Ford Health System	marketed	Opioid analgesic combination	Mu opioid receptor (hydrocodone); COX inhibitor (acetaminophen)
hydrocodone, acetaminophen and ibuprofen	hydrocodone, acetaminophen and ibuprofen	Albany Medical College	marketed	Opioid analgesic combination	Opioid receptors (hydrocodone); COX-1/COX-2 (ibuprofen); unclear (acetaminophen)
PCM/Oxy2	PCM/Oxy2	Maastricht University Medical Center	marketed	Opioid analgesic combination	Mu opioid receptor (oxycodone); COX enzymes (paracetamol)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Opioid analgesic combination class)

1. VA Office of Research and Development · 3 drugs in this class
2. Rothman Institute Orthopaedics · 2 drugs in this class
3. Labopharm Inc. · 2 drugs in this class
4. University of Rochester · 2 drugs in this class
5. Montefiore Medical Center · 2 drugs in this class
6. Maastricht University Medical Center · 2 drugs in this class
7. Henry Ford Health System · 1 drug in this class
8. Daewon Pharmaceutical Co., Ltd. · 1 drug in this class
9. Albert Einstein College of Medicine · 1 drug in this class
10. Johnson & Johnson Taiwan Ltd · 1 drug in this class