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Oxycontin/acetominophen
Oxycodone (an opioid agonist) binds to mu opioid receptors to reduce pain, while acetaminophen inhibits prostaglandin synthesis to provide additional analgesic and antipyretic effects.
Oxycodone (an opioid agonist) binds to mu opioid receptors to reduce pain, while acetaminophen inhibits prostaglandin synthesis to provide additional analgesic and antipyretic effects. Used for Moderate to severe acute pain, Moderate to severe chronic pain.
At a glance
| Generic name | Oxycontin/acetominophen |
|---|---|
| Also known as | Percoset |
| Sponsor | University of Rochester |
| Drug class | Opioid analgesic combination |
| Target | Mu opioid receptor (oxycodone); COX inhibitor (acetaminophen) |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | FDA-approved |
Mechanism of action
Oxycodone is a semi-synthetic opioid that activates mu opioid receptors in the central nervous system, modulating pain perception and emotional response to pain. Acetaminophen works through a separate mechanism, inhibiting cyclooxygenase enzymes and reducing prostaglandin production, providing complementary analgesia. The combination allows for enhanced pain relief at lower individual doses of each component.
Approved indications
- Moderate to severe acute pain
- Moderate to severe chronic pain
Common side effects
- Constipation
- Nausea
- Dizziness
- Drowsiness
- Vomiting
- Pruritus
- Respiratory depression
- Hepatotoxicity (acetaminophen-related)
Key clinical trials
- Examining Analgesic Synergy and Efficacy in Trauma Care (PHASE4)
- Nonopioid Analgesia After Anterior Cruciate Ligament Reconstruction (PHASE2, PHASE3)
- The Efficacy and Safety of Liposomal Bupivacaine for Transversus Abdominis Plane Block in Relieving Postoperative Pain After Laparoscopic Surgery (NA)
- The Efficacy and Safety of Liposomal Bupivacaine for Transversus Abdominis Plane Block in Relieving Postoperative Pain After Laparoscopic Surgery in Gynecologic Oncology (NA)
- The Efficacy and Safety of Liposomal Bupivacaine in Relieving Postoperative Pain After Laparoscopic Surgery (NA)
- Open-label Placebo (COLP) for Pain in Adolescent Idiopathic Scoliosis (AIS) Surgery+Surgical Treatment of Idiopathic Scoliosis (NA)
- Opioid-Free Pain Control Regimen Following Robotic Radical Prostatectomy (PHASE2, PHASE3)
- The Efficacy and Safety of Liposomal Bupivacaine in Relieving Postoperative Pain After Video-assisted Thoracoscopic Surgery (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Oxycontin/acetominophen CI brief — competitive landscape report
- Oxycontin/acetominophen updates RSS · CI watch RSS
- University of Rochester portfolio CI