Last reviewed · How we verify
Tramadol HCl-Paracetamol
Tramadol HCl-Paracetamol is a Opioid analgesic combination Small molecule drug developed by Xian-Janssen Pharmaceutical Ltd.. It is currently FDA-approved for Moderate pain management, Post-operative pain, Musculoskeletal pain.
This combination drug reduces pain through dual action: tramadol inhibits monoamine reuptake and activates opioid receptors, while paracetamol inhibits prostaglandin synthesis.
This combination drug reduces pain through dual action: tramadol inhibits monoamine reuptake and activates opioid receptors, while paracetamol inhibits prostaglandin synthesis. Used for Moderate pain management, Post-operative pain, Musculoskeletal pain.
At a glance
| Generic name | Tramadol HCl-Paracetamol |
|---|---|
| Sponsor | Xian-Janssen Pharmaceutical Ltd. |
| Drug class | Opioid analgesic combination |
| Target | Opioid receptors (μ, δ, κ); monoamine transporters (norepinephrine, serotonin); cyclooxygenase enzymes |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | FDA-approved |
Mechanism of action
Tramadol is a synthetic opioid agonist that also blocks the reuptake of norepinephrine and serotonin, enhancing pain modulation through multiple pathways. Paracetamol (acetaminophen) works as an analgesic and antipyretic by inhibiting cyclooxygenase enzymes and reducing prostaglandin production. Together, they provide synergistic analgesia for moderate pain relief.
Approved indications
- Moderate pain management
- Post-operative pain
- Musculoskeletal pain
Common side effects
- Nausea
- Dizziness
- Constipation
- Headache
- Somnolence
- Vomiting
Key clinical trials
- Serratus Plane Block (SPB) Versus Capsaïcine Versus Botox-A for Chronic Neuropathic Pain in Post-mastectomy Syndrome (PHASE2)
- Analgesic Efficacy and Obstetric Effects of Tramadol, Paracetamol and Placebo in Active Labor (PHASE4)
- Opioid-Free Pain Protocol After Shoulder Arthroplasty (PHASE4)
- Intravenous Paracetamol Versus Intramuscular Tramadol in Shortening the Duration of Labour. (NA)
- Investigation of the Effect of Proximal and Distal Adductor Canal Block in Knee Replacement Surgery (NA)
- Effect of Peng Block Application on Inflammation and Mortality in Hip Fractures (NA)
- Efficacy of Peripheral Nerve Blocks in Total Knee Arthroplasty (NA)
- Serratus Anterior Plane Block and Serratus Anterior Plane Block + Continuous Wound Infiltration With Catheter (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Tramadol HCl-Paracetamol CI brief — competitive landscape report
- Tramadol HCl-Paracetamol updates RSS · CI watch RSS
- Xian-Janssen Pharmaceutical Ltd. portfolio CI
Frequently asked questions about Tramadol HCl-Paracetamol
What is Tramadol HCl-Paracetamol?
How does Tramadol HCl-Paracetamol work?
What is Tramadol HCl-Paracetamol used for?
Who makes Tramadol HCl-Paracetamol?
What drug class is Tramadol HCl-Paracetamol in?
What development phase is Tramadol HCl-Paracetamol in?
What are the side effects of Tramadol HCl-Paracetamol?
What does Tramadol HCl-Paracetamol target?
Related
- Drug class: All Opioid analgesic combination drugs
- Target: All drugs targeting Opioid receptors (μ, δ, κ); monoamine transporters (norepinephrine, serotonin); cyclooxygenase enzymes
- Manufacturer: Xian-Janssen Pharmaceutical Ltd. — full pipeline
- Therapeutic area: All drugs in Pain Management
- Indication: Drugs for Moderate pain management
- Indication: Drugs for Post-operative pain
- Indication: Drugs for Musculoskeletal pain
- Compare: Tramadol HCl-Paracetamol vs similar drugs
- Pricing: Tramadol HCl-Paracetamol cost, discount & access